B4EK77 (ACDH1_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 1
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1

Gene names

Name:	mhpF
Ordered Locus Names:	BceJ2315_50630
ORF Names:	BCAM1614

Organism

Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]

Taxonomic identifier

216591 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia cenocepacia

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657		PRO_0000387630
Regions
	Nucleotide binding	161 – 169	9	NAD By similarity
Sites
	Active site	130	1	Acyl-thioester intermediate By similarity
	Binding site	272	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4EK77 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 1DBCB02BDFFD65BC	FASTA	299	31,661
	10 20 30 40 50 60 MKKIKCALIG PGNIGTDLLY KLRRSPVLEP VWMVGVDPAS DGLARAREFG LKTTDKGVDG 70 80 90 100 110 120 LLPHVVGDEI RIAFDATSAY VHRDNSDKLT ALGVKMIDLT PAAIGPYCVP PVNLDAHLDS 130 140 150 160 170 180 AQTNVNMVTC GGQATIPMVY AVSRVQPVAY GEIVATVSSR SVGPGTRKNI DEFTRTTSGA 190 200 210 220 230 240 IEQVGGARKG KAIIVINPAE PPLIMRDTIH CLTDGPPDVD AITASVHAMV KEVQRYVPGY 250 260 270 280 290 TLKNGPVFDG NRVSVFMEVE GLGDYLPKYA GNLDIMTAAA AATAERFAEQ MLAATAATA

References

[1]	"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen." Holden M.T.G. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J2315 / LMG 16656.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM747721 Genomic DNA. Translation: CAR55470.1.
RefSeq	YP_002234226.1. NC_011001.1.
3D structure databases
ProteinModelPortal	B4EK77.
ModBase	Search...
Protein-protein interaction databases
STRING	216591.BCAM1614.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6929258.
KEGG	bcj:BCAM1614.
PATRIC	19082533. VBIBurCen118154_5382.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HOG000052149.
KO	K04073.
OMA	HAMVKEV.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	BCEN216591:GJI4-5240-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01657. Ac_ald_DH_ac.
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. PTHR21123. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH1_BURCJ

Accession

Primary (citable) accession number: B4EK77

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program