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Reviewed, UniProtKB/Swiss-Prot B4EHJ2 (BETA_BURCJ)

Last modified November 3, 2009. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1
Gene names
Name: betA
Ordered Locus Names: BceJ2315_57790
ORF Names: BCAM2343
OrganismBurkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]
Taxonomic identifier216591 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

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Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750

Cofactor

FAD By similarity.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Choline dehydrogenase HAMAP MF_00750
PRO_1000133322

Regions

Nucleotide binding7 – 3630FAD Probable

Sites

Active site4741 By similarity

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Sequences

Sequence LengthMass (Da)Tools
B4EHJ2-1 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 43360F7D057E28B5

FASTA56662,769
        10         20         30         40         50         60 
MTTREYDYII CGAGSAGNVL ATRLTEDPDV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG 

        70         80         90        100        110        120 
RRYNWAYETD PEPHMDNRRM ECGRGKGLGG SSLINGMCYI RGNALDYDNW STHKGLENWT 

       130        140        150        160        170        180 
YLDCLPYFKK AETRDVGPND YHGGSGPVSV TTSKPGVNPL FEAMVDAGVQ AGYPRTDDLN 

       190        200        210        220        230        240 
GYQQEGFGPM DRTVTPKGRR ASTARGYLDQ AKARPNLEIV THALADRILF DGKRASGVTY 

       250        260        270        280        290        300 
LRGSERATAH ARREVLVCSG AIASPQLLQR SGVGPGAWLK ALDIPVVLDL PGVGQNLQDH 

       310        320        330        340        350        360 
LEMYIQYECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI RTRDDDPWPN 

       370        380        390        400        410        420 
IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL RSRDPNDHPS ILFNYMAEAL 

       430        440        450        460        470        480 
DWREFRDAIR ATREIMRQPA LDRYRGRELN PGADCKTDKE LDAFVRARAE TAFHPSCSCK 

       490        500        510        520        530        540 
MGYDDMAVVD EEGRVHGLDG LRVVDASIMP IITTGNLNAP TIMIAEKIAD KIRGRTPLAR 

       550        560 
VDVPYFVANG APARNVAKAV RQPETV

« Hide

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References

[1]"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen."
Holden M.T.G.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AM747721 Genomic DNA. Translation: CAR56202.1.
RefSeqYP_002234942.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6930396.
GenomeReviewsGene locus BceJ2315_57790 in contig AM747721_GR.
KEGGbcj:BCAM2343.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAPNLQYHF.

Family and domain databases

HAMAPMF_00750.
[Tree]
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameBETA_BURCJ
AccessionPrimary (citable) accession number: B4EHJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 3, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents