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B4EHJ1 (BETB_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:BceJ2315_57780
ORF Names:BCAM2342
OrganismBurkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]
Taxonomic identifier216591 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex ›

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000133942

Regions

Nucleotide binding228 – 2336NAD By similarity

Sites

Active site2511 By similarity
Active site2851 By similarity

Sequences

Sequence LengthMass (Da)Tools
B4EHJ1 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 76FA6D83F83DDEED

FASTA48952,332
        10         20         30         40         50         60 
MSVYGLQRLY IGGGYVDATS GKTFDTFDPA TGELLAQVQQ ASAADVDRAV ASAQEGQREW 

        70         80         90        100        110        120 
AAMTAMQRSR ILRRAVDLLR ERNDELAAIE TRDTGKPIGE TLAVDIVTGA DVIEYYAGLA 

       130        140        150        160        170        180 
TAIEGLQVPL RAESFVYTRR EPLGVCAGIG AWNYPIQIAC WKTAPALAAG NAMVFKPSEV 

       190        200        210        220        230        240 
TPLTALKLAE IYTEAGVPAG VFNVVQGDGS VGALLTGHPD IAKVSFTGGV ETGKKVMSLA 

       250        260        270        280        290        300 
GASSLKEVTM ELGGKSPLIV FDDADLDRAA DIAVTANFFS SGQVCTNGTR VFMHRSVKDA 

       310        320        330        340        350        360 
FTQKVLERVK RIRVGKPTDA DTNFGPLVSA AQLDKVLGFI ESGKAEGAKL LAGGTRLTDG 

       370        380        390        400        410        420 
HFGSGQYVAP TVFGDCRDDM KIVREEIFGP VMSILDFESE DEVIARANDT HYGLAAGVVT 

       430        440        450        460        470        480 
ENLSRAHRTI HRLEAGICWI NTWGESPAEM PVGGYKQSGV GRENGITTLE HYTRIKSVQV 


ELGRYNPVF

« Hide

References

[1]"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen."
Holden M.T.G.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J2315 / LMG 16656.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM747721 Genomic DNA. Translation: CAR56201.1.
RefSeqYP_002234941.1. NC_011001.1.

3D structure databases

ProteinModelPortalB4EHJ1.
ModBaseSearch...

Protein-protein interaction databases

STRING216591.BCAM2342.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6930398.
KEGGbcj:BCAM2342.
PATRIC19084036. VBIBurCen118154_6134.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMANQQQVGD.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycBCEN216591:GJI4-5973-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_BURCJ
AccessionPrimary (citable) accession number: B4EHJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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