B4EG04 (ARGC_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BceJ2315_34880
ORF Names:	BCAM0018

Organism

Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]

Taxonomic identifier

216591 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm By similarity HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_1000137113
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4EG04 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 80661F727C022EE9	FASTA	313	33,140
	10 20 30 40 50 60 MSFPTVFIDG DQGTTGLQIH ARLRDRTDVR LLTLPAAERK DPARRADALN ACDIAVLCLP 70 80 90 100 110 120 DAAAREAVGF IRNPAVRVID ASSAHRTQPD WVYGFPEMAD GHAQDIAHAK RVTNPGCYPT 130 140 150 160 170 180 GAIGLLRPLL QAGLLPRDYP VSIHAVSGYS GGGRAAVDAF ESADAATPPL PLQVYGLALE 190 200 210 220 230 240 HKHVPEIRQH AGLAHRPFFV PAYGAYRQGI VLTIPIELRL LPAGVTGERL HACLAHHYAD 250 260 270 280 290 300 ARHVDVTPLA DAAAATHLDP QALNGTNDLR LGVFVNEARG QVLLSAVFDN LGKGASGAAV 310 QNLDLMLGAS SAA

References

[1]	"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen." Holden M.T.G. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J2315 / LMG 16656.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM747721 Genomic DNA. Translation: CAR53873.1.
RefSeq	YP_002232651.1. NC_011001.1.
3D structure databases
ProteinModelPortal	B4EG04.
ModBase	Search...
Protein-protein interaction databases
STRING	B4EG04.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6927833.
GenomeReviews	Gene locus BceJ2315_34880 in contig AM747721_GR.
KEGG	bcj:BCAM0018.
PATRIC	19079143. VBIBurCen118154_3690.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG294213.
OMA	EIQQHAG.
ProtClustDB	PRK11863.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BURCJ

Accession

Primary (citable) accession number: B4EG04

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program