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B4EFS7 (3HAO_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Gene names
Name:nbaC
Ordered Locus Names:BceJ2315_55670
ORF Names:BCAM2130
OrganismBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)) [Complete proteome] [HAMAP]
Taxonomic identifier216591 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_00825

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_00825

Cofactor

Binds 2 Fe2+ ions per subunit By similarity. HAMAP-Rule MF_00825

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_00825

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00825

Sequence similarities

Belongs to the 3-HAO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1771773-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_00825
PRO_1000134548

Sites

Metal binding511Iron 1; catalytic By similarity
Metal binding571Iron 1; catalytic By similarity
Metal binding951Iron 1; catalytic By similarity
Metal binding1251Iron 2 By similarity
Metal binding1281Iron 2 By similarity
Metal binding1621Iron 2 By similarity
Metal binding1651Iron 2 By similarity
Binding site471Dioxygen By similarity
Binding site571Substrate By similarity
Binding site991Substrate By similarity
Binding site1101Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B4EFS7 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 637127F4FCA2D09D

FASTA17720,646
        10         20         30         40         50         60 
MLSYGKPFNF QRWIDEHVHL LKPPVGNQQV WQDSDFIVTV VGGPNRRTDY HDDPLEEFFY 

        70         80         90        100        110        120 
QLRGNAYLNL WIDGKRERVE LKEGDVFLLP PHVRHSPQRP ESGSACLVIE RQRPEGTVDG 

       130        140        150        160        170 
FEWYCDACGE RVHRVELQLK SIVNDLPPLF DAFYESEEKR RCPRCGVVHP GKQGRTD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM747721 Genomic DNA. Translation: CAR55988.1.
RefSeqYP_002234730.1. NC_011001.1.

3D structure databases

ProteinModelPortalB4EFS7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216591.BCAM2130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6930562.
KEGGbcj:BCAM2130.
PATRIC19083569. VBIBurCen118154_5901.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG77058.
HOGENOMHOG000218448.
KOK00452.
OMAHINQTPE.
OrthoDBEOG6PW234.
ProtClustDBPRK13264.

Enzyme and pathway databases

BioCycBCEN216591:GJI4-5758-MONOMER.
UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_BURCJ
AccessionPrimary (citable) accession number: B4EFS7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways