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B4EFS7 (3HAO_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase
EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Gene names
Ordered Locus Names:BceJ2315_55670
ORF Names:BCAM2130
OrganismBurkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]
Taxonomic identifier216591 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP MF_00825

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP MF_00825

Cofactor

Binds 2 Fe2+ ions per subunit By similarity. HAMAP MF_00825

Subunit structure

Homodimer By similarity. HAMAP MF_00825

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1771773-hydroxyanthranilate 3,4-dioxygenase HAMAP MF_00825
PRO_1000134548

Sites

Metal binding511Iron 1; catalytic By similarity
Metal binding571Iron 1; catalytic By similarity
Metal binding951Iron 1; catalytic By similarity
Metal binding1251Iron 2 By similarity
Metal binding1281Iron 2 By similarity
Metal binding1621Iron 2 By similarity
Metal binding1651Iron 2 By similarity
Binding site471Dioxygen By similarity
Binding site571Substrate By similarity
Binding site991Substrate By similarity
Binding site1101Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B4EFS7 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 637127F4FCA2D09D

FASTA17720,646
        10         20         30         40         50         60 
MLSYGKPFNF QRWIDEHVHL LKPPVGNQQV WQDSDFIVTV VGGPNRRTDY HDDPLEEFFY 

        70         80         90        100        110        120 
QLRGNAYLNL WIDGKRERVE LKEGDVFLLP PHVRHSPQRP ESGSACLVIE RQRPEGTVDG 

       130        140        150        160        170 
FEWYCDACGE RVHRVELQLK SIVNDLPPLF DAFYESEEKR RCPRCGVVHP GKQGRTD

« Hide

References

[1]"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen."
Holden M.T.G.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J2315 / LMG 16656.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM747721 Genomic DNA. Translation: CAR55988.1.
RefSeqYP_002234730.1. NC_011001.1.

3D structure databases

ProteinModelPortalB4EFS7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4EFS7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6930562.
GenomeReviewsGene locus BceJ2315_55670 in contig AM747721_GR.
KEGGbcj:BCAM2130.
PATRIC19083569. VBIBurCen118154_5901.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG341987.
OMALKPPVNN.
ProtClustDBPRK13264.

Family and domain databases

HAMAPMF_00825. 3_HAO.
[Tree]
InterProIPR010329. 3hydroanth_dOase.
IPR011051. Cupin_RmlC_type.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
Gene3DG3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
KOK00452.
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMsTIGR03037. Anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_BURCJ
AccessionPrimary (citable) accession number: B4EFS7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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