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B4EFI8

- ACDH2_BURCJ

UniProt

B4EFI8 - ACDH2_BURCJ

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Protein
Acetaldehyde dehydrogenase 2
Gene
BceJ2315_55590, BCAM2122
Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Acyl-thioester intermediate By similarity
Binding sitei287 – 2871NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi160 – 1689NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBCEN216591:GJI4-5750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene namesi
Ordered Locus Names:BceJ2315_55590
ORF Names:BCAM2122
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000001035: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Acetaldehyde dehydrogenase 2UniRule annotation
PRO_0000387631Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216591.BCAM2122.

Structurei

3D structure databases

ProteinModelPortaliB4EFI8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiYVIPSIN.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B4EFI8-1 [UniParc]FASTAAdd to Basket

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MNDRVKVAII GPGNIGTDLM IKIMRNGRHL KMGAMVGVDP NSEGLARAAR    50
MDVATTAEGI DGLLRLDVFK EIDIVFDATS AGAHGRHNEL LQAHGVQVID 100
LTPAAIGPYV IPSINLEEEN ATNMNMVTCG GQATIPIVAA VSRIAKVHYA 150
EIVASISSRS AGPGTRANID EFTETTRAAI EKLGGAERGK AIIVLNPAEP 200
PLIMRDTVFV LSENAEPAAI EASIAEMVSS VQEYVPGYRL KQSVQFDAVP 250
PDMPLNVPGI GPRHGLKTSV FLEVEGAAHY LPSYAGNLDI MTSAALACGD 300
MMARRRMAAG IARGFKETAR 320
Length:320
Mass (Da):33,921
Last modified:September 23, 2008 - v1
Checksum:iF62D2ACE5CA1DD2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM747721 Genomic DNA. Translation: CAR55980.1.
RefSeqiYP_002234722.1. NC_011001.1.

Genome annotation databases

EnsemblBacteriaiCAR55980; CAR55980; BCAM2122.
GeneIDi6929722.
KEGGibcj:BCAM2122.
PATRICi19083553. VBIBurCen118154_5893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM747721 Genomic DNA. Translation: CAR55980.1 .
RefSeqi YP_002234722.1. NC_011001.1.

3D structure databases

ProteinModelPortali B4EFI8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216591.BCAM2122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR55980 ; CAR55980 ; BCAM2122 .
GeneIDi 6929722.
KEGGi bcj:BCAM2122.
PATRICi 19083553. VBIBurCen118154_5893.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi YVIPSIN.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BCEN216591:GJI4-5750-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610.

Entry informationi

Entry nameiACDH2_BURCJ
AccessioniPrimary (citable) accession number: B4EFI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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