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Protein

Acetaldehyde dehydrogenase 2

Gene

BceJ2315_55590

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129Acyl-thioester intermediateUniRule annotation1
Binding sitei287NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 168NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:BceJ2315_55590
ORF Names:BCAM2122
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001035 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876311 – 320Acetaldehyde dehydrogenase 2Add BLAST320

Interactioni

Protein-protein interaction databases

STRINGi216591.BCAM2122.

Structurei

3D structure databases

ProteinModelPortaliB4EFI8.
SMRiB4EFI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV. Bacteria.
COG4569. LUCA.
HOGENOMiHOG000052149.
KOiK04073.
OMAiTSAYVHK.
OrthoDBiPOG091H09NP.

Family and domain databases

HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiView protein in InterPro
IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
PfamiView protein in Pfam
PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B4EFI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDRVKVAII GPGNIGTDLM IKIMRNGRHL KMGAMVGVDP NSEGLARAAR
60 70 80 90 100
MDVATTAEGI DGLLRLDVFK EIDIVFDATS AGAHGRHNEL LQAHGVQVID
110 120 130 140 150
LTPAAIGPYV IPSINLEEEN ATNMNMVTCG GQATIPIVAA VSRIAKVHYA
160 170 180 190 200
EIVASISSRS AGPGTRANID EFTETTRAAI EKLGGAERGK AIIVLNPAEP
210 220 230 240 250
PLIMRDTVFV LSENAEPAAI EASIAEMVSS VQEYVPGYRL KQSVQFDAVP
260 270 280 290 300
PDMPLNVPGI GPRHGLKTSV FLEVEGAAHY LPSYAGNLDI MTSAALACGD
310 320
MMARRRMAAG IARGFKETAR
Length:320
Mass (Da):33,921
Last modified:September 23, 2008 - v1
Checksum:iF62D2ACE5CA1DD2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747721 Genomic DNA. Translation: CAR55980.1.
RefSeqiWP_006490293.1. NC_011001.1.

Genome annotation databases

EnsemblBacteriaiCAR55980; CAR55980; BCAM2122.
KEGGibcj:BCAM2122.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACDH2_BURCJ
AccessioniPrimary (citable) accession number: B4EFI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 23, 2008
Last modified: June 7, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families