B4EFI8 (ACDH2_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 2
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2

Gene names

Ordered Locus Names:	BceJ2315_55590
ORF Names:	BCAM2122

Organism

Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]

Taxonomic identifier

216591 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia cenocepacia

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Acetaldehyde dehydrogenase 2 HAMAP-Rule MF_01657		PRO_0000387631
Regions
	Nucleotide binding	160 – 168	9	NAD By similarity
Sites
	Active site	129	1	Acyl-thioester intermediate By similarity
	Binding site	287	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4EFI8 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: F62D2ACE5CA1DD2A	FASTA	320	33,921
	10 20 30 40 50 60 MNDRVKVAII GPGNIGTDLM IKIMRNGRHL KMGAMVGVDP NSEGLARAAR MDVATTAEGI 70 80 90 100 110 120 DGLLRLDVFK EIDIVFDATS AGAHGRHNEL LQAHGVQVID LTPAAIGPYV IPSINLEEEN 130 140 150 160 170 180 ATNMNMVTCG GQATIPIVAA VSRIAKVHYA EIVASISSRS AGPGTRANID EFTETTRAAI 190 200 210 220 230 240 EKLGGAERGK AIIVLNPAEP PLIMRDTVFV LSENAEPAAI EASIAEMVSS VQEYVPGYRL 250 260 270 280 290 300 KQSVQFDAVP PDMPLNVPGI GPRHGLKTSV FLEVEGAAHY LPSYAGNLDI MTSAALACGD 310 320 MMARRRMAAG IARGFKETAR

References

[1]	"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen." Holden M.T.G. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J2315 / LMG 16656.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM747721 Genomic DNA. Translation: CAR55980.1.
RefSeq	YP_002234722.1. NC_011001.1.
3D structure databases
ProteinModelPortal	B4EFI8.
ModBase	Search...
Protein-protein interaction databases
STRING	216591.BCAM2122.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6929722.
KEGG	bcj:BCAM2122.
PATRIC	19083553. VBIBurCen118154_5893.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HOG000052149.
KO	K04073.
OMA	MIKVIRH.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	BCEN216591:GJI4-5750-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01657. Ac_ald_DH_ac.
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. PTHR21123. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH2_BURCJ

Accession

Primary (citable) accession number: B4EFI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program