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B4EFI8 (ACDH2_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 2

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene names
Ordered Locus Names:BceJ2315_55590
ORF Names:BCAM2122
OrganismBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)) [Complete proteome] [HAMAP]
Taxonomic identifier216591 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Acetaldehyde dehydrogenase 2 HAMAP-Rule MF_01657
PRO_0000387631

Regions

Nucleotide binding160 – 1689NAD By similarity

Sites

Active site1291Acyl-thioester intermediate By similarity
Binding site2871NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B4EFI8 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: F62D2ACE5CA1DD2A

FASTA32033,921
        10         20         30         40         50         60 
MNDRVKVAII GPGNIGTDLM IKIMRNGRHL KMGAMVGVDP NSEGLARAAR MDVATTAEGI 

        70         80         90        100        110        120 
DGLLRLDVFK EIDIVFDATS AGAHGRHNEL LQAHGVQVID LTPAAIGPYV IPSINLEEEN 

       130        140        150        160        170        180 
ATNMNMVTCG GQATIPIVAA VSRIAKVHYA EIVASISSRS AGPGTRANID EFTETTRAAI 

       190        200        210        220        230        240 
EKLGGAERGK AIIVLNPAEP PLIMRDTVFV LSENAEPAAI EASIAEMVSS VQEYVPGYRL 

       250        260        270        280        290        300 
KQSVQFDAVP PDMPLNVPGI GPRHGLKTSV FLEVEGAAHY LPSYAGNLDI MTSAALACGD 

       310        320 
MMARRRMAAG IARGFKETAR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM747721 Genomic DNA. Translation: CAR55980.1.
RefSeqYP_002234722.1. NC_011001.1.

3D structure databases

ProteinModelPortalB4EFI8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216591.BCAM2122.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6929722.
KEGGbcj:BCAM2122.
PATRIC19083553. VBIBurCen118154_5893.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAMIKVIRH.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycBCEN216591:GJI4-5750-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH2_BURCJ
AccessionPrimary (citable) accession number: B4EFI8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families