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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Transition state stabilizerUniRule annotation
Active sitei92 – 921Proton acceptorUniRule annotation
Metal bindingi259 – 2591Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBCEN216591:GJI4-3379-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Synonyms:katB
Ordered Locus Names:BceJ2315_32390
ORF Names:BCAL3299
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001035 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Catalase-peroxidase 1PRO_0000354739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki91 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi216591.BCAL3299.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4EE21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNETKCPFN HTAGSGTTNK DWWPNQLNLN VLHRHSALSD PMDPDFDYAE
60 70 80 90 100
AFKKLDLAAV KQDLHALMTT SQDWWPADFG HYGGLFVRMA WHSAGTYRTA
110 120 130 140 150
DGRGGAGGGQ QRFAPLNSWP DNVSLDKARR LLWPIKQKYG RNISWADLLI
160 170 180 190 200
LTGNVALESM GFKTFGYAGG RVDTWEPDDV YWGSEKIWLE LSGGPNSRYT
210 220 230 240 250
GKRELESPLA AVQMGLIYVN PEGPDGNPDP VAAAHDIRET FARMAMNDEE
260 270 280 290 300
TVALIAGGHT FGKTHGAGPA SNVGPEPEAA GLEEQGLGWK STFGTGKGKD
310 320 330 340 350
TITSGLEVTW TSTPTKWSND FFKHLFSYEW ELTKSPAGAH QWVAKDADEV
360 370 380 390 400
IPDAYDASKK HRPTMLTTDL SLRFDPAYEK ISRRFYENPA EFADAFARAW
410 420 430 440 450
FKLTHRDMGP RSRYLGPEVP AEHLLWQDPI PAVDHPLIDD ADVAALKAKV
460 470 480 490 500
LATGLSVSQL VSTAWASAAT FRGSDKRGGA NGARIRLAPQ KDWEVNQPAA
510 520 530 540 550
LAAVLEALEG VQKAFNDAQT GGKKVSLADL IVLAGAAGVE QAAKNAGIAI
560 570 580 590 600
TVPFAPGRMD ASQEETDVDA MAVLEPLADG FRNYLKHPYK TPAEALLVDK
610 620 630 640 650
AQLLTLTAPE MTVLVGGLRV LGANVGDSKH GVFTDRPGTL SNDFFANLLD
660 670 680 690 700
MRTEWKPVSA ANDVFEGRDR ATGAVKWTGT RVDLIFGSHS QLRALAEVYG
710 720
SADAQEKFVR DFVAAWNKVM NLDRFDLA
Length:728
Mass (Da):79,445
Last modified:September 23, 2008 - v1
Checksum:i2329F69AD39C2779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA. Translation: CAR53623.1.
RefSeqiWP_006483659.1. NC_011000.1.

Genome annotation databases

EnsemblBacteriaiCAR53623; CAR53623; BCAL3299.
GeneIDi6933132.
KEGGibcj:BCAL3299.
PATRICi19078598. VBIBurCen118154_3422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA. Translation: CAR53623.1.
RefSeqiWP_006483659.1. NC_011000.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216591.BCAL3299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR53623; CAR53623; BCAL3299.
GeneIDi6933132.
KEGGibcj:BCAL3299.
PATRICi19078598. VBIBurCen118154_3422.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciBCEN216591:GJI4-3379-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610.

Entry informationi

Entry nameiKATG1_BURCJ
AccessioniPrimary (citable) accession number: B4EE21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: September 23, 2008
Last modified: November 11, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.