Reviewed,
UniProtKB/Swiss-Prot B4ECX5 (HGD_BURCJ)
Last modified
November 3, 2009.
Version 11.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homogentisate 1,2-dioxygenase EC=1.13.11.5 Alternative name(s): Homogentisicase Homogentisate oxygenase Homogentisic acid oxidase | ||||||
| Gene names |
| ||||||
| Organism | Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 216591 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex |
Protein attributes
| Sequence length | 444 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334 |
| Cofactor | Iron By similarity. |
| Pathway | Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334 |
| Sequence similarities | Belongs to the homogentisate dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phenylalanine catabolism Tyrosine catabolism |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 444 | 444 | Homogentisate 1,2-dioxygenase HAMAP MF_00334 | PRO_1000119842 | |||||
Sites | |||||||||
| Metal binding | 341 | 1 | Iron By similarity | ||||||
| Metal binding | 347 | 1 | Iron By similarity | ||||||
| Metal binding | 377 | 1 | Iron By similarity | ||||||
Sequences
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References
| [1] | "Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen." Holden M.T.G. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AM747720 Genomic DNA. Translation: CAR53507.1. | |
| RefSeq | YP_002232293.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 6933053. |
| GenomeReviews | Gene locus BceJ2315_31290 in contig AM747720_GR. |
| KEGG | bcj:BCAL3184. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | HRNCMSE. |
Family and domain databases | |
| HAMAP | MF_00334. [Tree] |
| InterPro | IPR005708. Homogentis_dOase. [Graphical view] |
| PANTHER | PTHR11056. Homogentis_dOase. 1 hit. |
| Pfam | PF04209. HgmA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01015. hmgA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HGD_BURCJ | ||||||||
| Accession | Primary (citable) accession number: B4ECX5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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