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B4EBL7 (G6PI_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:BceJ2315_19530
ORF Names:BCAL1990
OrganismBurkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]
Taxonomic identifier216591 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_1000125701

Sites

Active site3811 By similarity
Active site5031 By similarity

Sequences

Sequence LengthMass (Da)Tools
B4EBL7 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: DC8A669D3E4E528E

FASTA54059,244
        10         20         30         40         50         60 
MTLKSLPAWT ALQSHFEQIR HARLRDWFAP ENDRAPTRAE RFTIPGGGLA ADFSKNRIDD 

        70         80         90        100        110        120 
ETVRLLVQLA RDAGVEARRD AMFAGEIVNP TEGRAALHTA LRATDPQAPF HAQVSAERAK 

       130        140        150        160        170        180 
MATFARAVRS GTWTGYTGKR IRHVINIGIG GSDLGPKMVV HALHHVATPE ISTHFVSNVD 

       190        200        210        220        230        240 
GADLARVLEQ VDPEETLAII VSKTFTTLET MTNARSLRDW FVARGCPEDA LAKHFVGVSA 

       250        260        270        280        290        300 
NPAEVVKFGI AADNVFEMWD WVGGRYSLWS AVGLSIMIAV GPEQFDELLA GANDMDRHFR 

       310        320        330        340        350        360 
EAPLERNLPV LLGLIGIWYR NFFGSQSYLV APYSEALHYL PSYLQQLEME SNGKSARLDG 

       370        380        390        400        410        420 
TFVDYPTSAV TWGEPGTNGQ HAFFQMLHQG PTIVPIDFIA VLTPEHPLAS HHPKLLANCF 

       430        440        450        460        470        480 
AQSEALMLGR TLEEARKVAG PGKEALAPHL TFPGNRPTTT LLVDALTPRA LGALIALYEH 

       490        500        510        520        530        540 
KVLVQATVWD INPFDQWGVE LGKILGKVVE ADLSAESVDP AKHDSSTTAL IERARAALKR

« Hide

References

[1]"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen."
Holden M.T.G.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J2315 / LMG 16656.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM747720 Genomic DNA. Translation: CAR52290.1.
RefSeqYP_002231117.1. NC_011000.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB4EBL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6932168.
GenomeReviewsGene locus BceJ2315_19530 in contig AM747720_GR.
KEGGbcj:BCAL1990.
PATRIC19075813. VBIBurCen118154_2065.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG352954.
OMANSLPAWT.
ProtClustDBPRK00179.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
Gene3DG3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_BURCJ
AccessionPrimary (citable) accession number: B4EBL7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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