B4EBK9 (MSRB_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	BceJ2315_19450
ORF Names:	BCAL1982

Organism

Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]

Taxonomic identifier

216591 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 143	143	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000145354
Sites
	Active site	128	1	Nucleophile By similarity
	Metal binding	55	1	Zinc By similarity
	Metal binding	58	1	Zinc By similarity
	Metal binding	104	1	Zinc By similarity
	Metal binding	107	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4EBK9 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: C28E9BC11C024551	FASTA	143	16,230
	10 20 30 40 50 60 MSHDSDDKTF PYQKDDAELR RRLTPMQYEV TQHAATERAF TGEYTDTEDA GIYKCVVCST 70 80 90 100 110 120 PLFESGAKFH SGCGWPSYFK PLNGEVIDEK IDYSHGMVRV EVRCNHCGAH LGHVFEDGPR 130 140 DKTGLRYCIN SAALNFESRP ENE

References

[1]	"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen." Holden M.T.G. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J2315 / LMG 16656.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM747720 Genomic DNA. Translation: CAR52282.1.
RefSeq	YP_002231109.1. NC_011000.1.
3D structure databases
ProteinModelPortal	B4EBK9.
ModBase	Search...
Protein-protein interaction databases
STRING	B4EBK9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6932162.
GenomeReviews	Gene locus BceJ2315_19450 in contig AM747720_GR.
KEGG	bcj:BCAL1982.
PATRIC	19075797. VBIBurCen118154_2057.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG715255.
OMA	FTDGPVD.
ProtClustDB	CLSK930638.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_BURCJ

Accession

Primary (citable) accession number: B4EBK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program