B4EB41 (KCY_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	BceJ2315_28870
ORF Names:	BCAL2951

Organism

Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]

Taxonomic identifier

216591 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Cytidylate kinase HAMAP MF_00238		PRO_1000100652
Regions
	Nucleotide binding	17 – 25	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4EB41 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 532E84F3BF1C0E10	FASTA	228	24,351
	10 20 30 40 50 60 MKSTRPFHPT PVITIDGPTA SGKGTVAALV AAHLGFHLLD SGALYRLAAL ASVRYGIAAE 70 80 90 100 110 120 DIDALVKLID DLHITFREGC AQLDGVDVSN DIRAEAVGNR ASAIAVHGPV RAALVARQRA 130 140 150 160 170 180 FRKTPGLVAD GRDMGTVIFP DAVLKVFLTA SAEARATRRH KQLMQKGFSA NIDDLLRDLR 190 200 210 220 ERDARDSNRA AAPLKPAADA KLLDTSALSV DEAVDQVLQW YRALGQPA

References

[1]	"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen." Holden M.T.G. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J2315 / LMG 16656.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM747720 Genomic DNA. Translation: CAR53254.1.
RefSeq	YP_002232051.1. NC_011000.1.
3D structure databases
ProteinModelPortal	B4EB41.
ModBase	Search...
Protein-protein interaction databases
STRING	B4EB41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6934100.
GenomeReviews	Gene locus BceJ2315_28870 in contig AM747720_GR.
KEGG	bcj:BCAL2951.
PATRIC	19077858. VBIBurCen118154_3059.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG354377.
OMA	DIGTVIC.
ProtClustDB	PRK00023.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_BURCJ

Accession

Primary (citable) accession number: B4EB41

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program