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B4EAU4

- B4EAU4_BURCJ

UniProt

B4EAU4 - B4EAU4_BURCJ

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Protein
Submitted name:

Putative Acetoacetyl-CoA reductase

Gene

phbB

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101NADP; via carbonyl oxygenImported
Binding sitei153 – 1531NADPImported
Binding sitei157 – 1571NADPImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 152NADPImported
Nucleotide bindingi35 – 384NADPImported
Nucleotide bindingi61 – 622NADPImported
Nucleotide bindingi88 – 903NADPImported
Nucleotide bindingi186 – 1883NADPImported

GO - Molecular functioni

  1. acetoacetyl-CoA reductase activity Source: UniProtKB-EC
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. poly-hydroxybutyrate biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

NADPImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciBCEN216591:GJI4-858-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative Acetoacetyl-CoA reductaseImported (EC:1.1.1.36Imported)
Gene namesi
Name:phbBImported
ORF Names:BCAL0833Imported
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))Imported
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000001035: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi216591.BCAL0833.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4K6CX-ray1.85A/B1-247[»]
4K6FX-ray1.50A/B/C/D1-247[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1028.
KOiK00023.
OMAiAICIKLA.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4EAU4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKRIAVVTG GMGGLGEAVS IRLNDAGHRV VVTYSPNNTG ADRWLTEMHA
60 70 80 90 100
AGREFHAYPV DVADHDSCQQ CIEKIVRDVG PVDILVNNAG ITRDMTLRKL
110 120 130 140 150
DKVNWDAVIR TNLDSVFNMT KPVCDGMVER GWGRIVNISS VNGSKGSVGQ
160 170 180 190 200
TNYAAAKAGM HGFTKSLALE IARKGVTVNT VSPGYLATKM VTAIPQDILD
210 220 230 240
TKILPQIPAG RLGKPEEVAA LVAYLCSEEA GFVTGSNIAI NGGQHMH
Length:247
Mass (Da):26,383
Last modified:September 23, 2008 - v1
Checksum:iB9F04F0E7FF1FE83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM747720 Genomic DNA. Translation: CAR51139.1.
RefSeqiYP_002229987.1. NC_011000.1.

Genome annotation databases

EnsemblBacteriaiCAR51139; CAR51139; BCAL0833.
GeneIDi6933950.
KEGGibcj:BCAL0833.
PATRICi19073398. VBIBurCen118154_0874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM747720 Genomic DNA. Translation: CAR51139.1 .
RefSeqi YP_002229987.1. NC_011000.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4K6C X-ray 1.85 A/B 1-247 [» ]
4K6F X-ray 1.50 A/B/C/D 1-247 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216591.BCAL0833.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR51139 ; CAR51139 ; BCAL0833 .
GeneIDi 6933950.
KEGGi bcj:BCAL0833.
PATRICi 19073398. VBIBurCen118154_0874.

Phylogenomic databases

eggNOGi COG1028.
KOi K00023.
OMAi AICIKLA.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

BioCyci BCEN216591:GJI4-858-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610Imported.
  2. "X-ray crystal structure of a putative Acetoacetyl-CoA reductase from Burkholderia cenocepacia bound to the co-factor NADP."
    Fairman J.W., Edwards T.E., Lorimer D.
    Submitted (APR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH NADP.
  3. "X-ray crystal structure of a putative Acetoacyl-CoA reductase from Burkholderia cenocepacia."
    Fairman J.W., Edwards T.E., Lorimer D.
    Submitted (APR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

Entry informationi

Entry nameiB4EAU4_BURCJ
AccessioniPrimary (citable) accession number: B4EAU4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3