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Protein
Submitted name:

Putative Acetoacetyl-CoA reductase

Gene

phbB

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101NADP; via carbonyl oxygenCombined sources
Binding sitei153 – 1531NADPCombined sources
Binding sitei157 – 1571NADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 152NADPCombined sources
Nucleotide bindingi35 – 384NADPCombined sources
Nucleotide bindingi61 – 622NADPCombined sources
Nucleotide bindingi88 – 903NADPCombined sources
Nucleotide bindingi186 – 1883NADPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciBCEN216591:GJI4-858-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative Acetoacetyl-CoA reductaseImported (EC:1.1.1.36Imported)
Gene namesi
Name:phbBImported
ORF Names:BCAL0833Imported
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))Imported
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000001035 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi216591.BCAL0833.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4K6CX-ray1.85A/B1-247[»]
4K6FX-ray1.50A/B/C/D1-247[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1028.
KOiK00023.
OMAiTVHETAK.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4EAU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKRIAVVTG GMGGLGEAVS IRLNDAGHRV VVTYSPNNTG ADRWLTEMHA
60 70 80 90 100
AGREFHAYPV DVADHDSCQQ CIEKIVRDVG PVDILVNNAG ITRDMTLRKL
110 120 130 140 150
DKVNWDAVIR TNLDSVFNMT KPVCDGMVER GWGRIVNISS VNGSKGSVGQ
160 170 180 190 200
TNYAAAKAGM HGFTKSLALE IARKGVTVNT VSPGYLATKM VTAIPQDILD
210 220 230 240
TKILPQIPAG RLGKPEEVAA LVAYLCSEEA GFVTGSNIAI NGGQHMH
Length:247
Mass (Da):26,383
Last modified:September 23, 2008 - v1
Checksum:iB9F04F0E7FF1FE83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA. Translation: CAR51139.1.
RefSeqiWP_012492403.1. NC_011000.1.

Genome annotation databases

EnsemblBacteriaiCAR51139; CAR51139; BCAL0833.
GeneIDi6933950.
KEGGibcj:BCAL0833.
PATRICi19073398. VBIBurCen118154_0874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA. Translation: CAR51139.1.
RefSeqiWP_012492403.1. NC_011000.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4K6CX-ray1.85A/B1-247[»]
4K6FX-ray1.50A/B/C/D1-247[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216591.BCAL0833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR51139; CAR51139; BCAL0833.
GeneIDi6933950.
KEGGibcj:BCAL0833.
PATRICi19073398. VBIBurCen118154_0874.

Phylogenomic databases

eggNOGiCOG1028.
KOiK00023.
OMAiTVHETAK.
OrthoDBiEOG6N3CR8.

Enzyme and pathway databases

BioCyciBCEN216591:GJI4-858-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610Imported.
  2. "X-ray crystal structure of a putative Acetoacetyl-CoA reductase from Burkholderia cenocepacia bound to the co-factor NADP."
    Fairman J.W., Edwards T.E., Lorimer D.
    Submitted (APR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH NADP.
  3. "X-ray crystal structure of a putative Acetoacyl-CoA reductase from Burkholderia cenocepacia."
    Fairman J.W., Edwards T.E., Lorimer D.
    Submitted (APR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

Entry informationi

Entry nameiB4EAU4_BURCJ
AccessioniPrimary (citable) accession number: B4EAU4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 22, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.