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B4EAU4

- B4EAU4_BURCJ

UniProt

B4EAU4 - B4EAU4_BURCJ

Protein
Submitted name:

Putative Acetoacetyl-CoA reductase

Gene

phbB

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101NADP; via carbonyl oxygenImported
    Binding sitei153 – 1531NADPImported
    Binding sitei157 – 1571NADPImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 152NADPImported
    Nucleotide bindingi35 – 384NADPImported
    Nucleotide bindingi61 – 622NADPImported
    Nucleotide bindingi88 – 903NADPImported
    Nucleotide bindingi186 – 1883NADPImported

    GO - Molecular functioni

    1. acetoacetyl-CoA reductase activity Source: UniProtKB-EC
    2. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. poly-hydroxybutyrate biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    NADPImported, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciBCEN216591:GJI4-858-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative Acetoacetyl-CoA reductaseImported (EC:1.1.1.36Imported)
    Gene namesi
    Name:phbBImported
    ORF Names:BCAL0833Imported
    OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))Imported
    Taxonomic identifieri216591 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000001035: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi216591.BCAL0833.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4K6CX-ray1.85A/B1-247[»]
    4K6FX-ray1.50A/B/C/D1-247[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1028.
    KOiK00023.
    OMAiAICIKLA.
    OrthoDBiEOG6N3CR8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR011283. Acetoacetyl-CoA_reductase.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsiTIGR01829. AcAcCoA_reduct. 1 hit.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4EAU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKRIAVVTG GMGGLGEAVS IRLNDAGHRV VVTYSPNNTG ADRWLTEMHA    50
    AGREFHAYPV DVADHDSCQQ CIEKIVRDVG PVDILVNNAG ITRDMTLRKL 100
    DKVNWDAVIR TNLDSVFNMT KPVCDGMVER GWGRIVNISS VNGSKGSVGQ 150
    TNYAAAKAGM HGFTKSLALE IARKGVTVNT VSPGYLATKM VTAIPQDILD 200
    TKILPQIPAG RLGKPEEVAA LVAYLCSEEA GFVTGSNIAI NGGQHMH 247
    Length:247
    Mass (Da):26,383
    Last modified:September 23, 2008 - v1
    Checksum:iB9F04F0E7FF1FE83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM747720 Genomic DNA. Translation: CAR51139.1.
    RefSeqiYP_002229987.1. NC_011000.1.

    Genome annotation databases

    EnsemblBacteriaiCAR51139; CAR51139; BCAL0833.
    GeneIDi6933950.
    KEGGibcj:BCAL0833.
    PATRICi19073398. VBIBurCen118154_0874.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM747720 Genomic DNA. Translation: CAR51139.1 .
    RefSeqi YP_002229987.1. NC_011000.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4K6C X-ray 1.85 A/B 1-247 [» ]
    4K6F X-ray 1.50 A/B/C/D 1-247 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216591.BCAL0833.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR51139 ; CAR51139 ; BCAL0833 .
    GeneIDi 6933950.
    KEGGi bcj:BCAL0833.
    PATRICi 19073398. VBIBurCen118154_0874.

    Phylogenomic databases

    eggNOGi COG1028.
    KOi K00023.
    OMAi AICIKLA.
    OrthoDBi EOG6N3CR8.

    Enzyme and pathway databases

    BioCyci BCEN216591:GJI4-858-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR011283. Acetoacetyl-CoA_reductase.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsi TIGR01829. AcAcCoA_reduct. 1 hit.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610Imported.
    2. "X-ray crystal structure of a putative Acetoacetyl-CoA reductase from Burkholderia cenocepacia bound to the co-factor NADP."
      Fairman J.W., Edwards T.E., Lorimer D.
      Submitted (APR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH NADP.
    3. "X-ray crystal structure of a putative Acetoacyl-CoA reductase from Burkholderia cenocepacia."
      Fairman J.W., Edwards T.E., Lorimer D.
      Submitted (APR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

    Entry informationi

    Entry nameiB4EAU4_BURCJ
    AccessioniPrimary (citable) accession number: B4EAU4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3