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B4E9J0 (B4E9J0_BURCJ) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
B4E9J0 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 5D65F8E0654C0095

FASTA41745,366
        10         20         30         40         50         60 
MIKTREDALA LDRDDPLAPL RDQFSLPDGV IYLDGNSLGA QPRASAARAQ QVIGAEWGEG 

        70         80         90        100        110        120 
LIRSWNTAGW FALPRRLGDK LATLIGGAPG ETVVTDTISI NLFKLLSAML RHQAERAPER 

       130        140        150        160        170        180 
RVIVSERSNF PTDLYIAQGL IDQLGGGYTL RLIDDPADLP GALGADTAVA MITHVNYRTG 

       190        200        210        220        230        240 
YMHDMPAVTQ LVHDAGALML WDLAHSAGAV PVDLNGARAD GAVGCTYKYL NGGPGSPAFV 

       250        260        270        280        290        300 
WVPQRHLAHF SQPLSGWWGH RAPFAMQPGF APDPGIARFL CGTQPIVSMS MVECGLDVFL 

       310        320        330        340        350        360 
QTDMDAIRRK SLALTDAFIA LVEARCAGLS LKLVTPRAHH QRGSQASFEH PHGYEVMQAL 

       370        380        390        400        410 
IARGVIGDYR EPYVLRFGFT PLYTRFADVW DAVETLRDIL ATDAWKAPEF AERGAVT

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References

[1]"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen."
Holden M.T.G.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J2315 / LMG 16656.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM747720 Genomic DNA. Translation: CAR53091.1.
RefSeqYP_002231893.1. NC_011000.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING216591.BCAL2791.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6932795.
KEGGbcj:BCAL2791.
PATRIC19077512. VBIBurCen118154_2890.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3844.
HOGENOMHOG000242437.
KOK01556.
OMAMLTHVNY.
ProtClustDBCLSK866997.

Enzyme and pathway databases

BioCycBCEN216591:GJI4-2846-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB4E9J0_BURCJ
AccessionPrimary (citable) accession number: B4E9J0
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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