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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

Cofactori

dipyrromethaneUniRule annotationNote: Binds 1 dipyrromethane group covalently.UniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Short name:
HMBSUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotation
Ordered Locus Names:BceJ2315_25700
ORF Names:BCAL2630
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001035 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001141381 – 334Porphobilinogen deaminaseAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei255S-(dipyrrolylmethanemethyl)cysteineUniRule annotation1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi216591.BCAL2630.

Structurei

3D structure databases

SMRiB4E8C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D6W. Bacteria.
COG0181. LUCA.
HOGENOMiHOG000228587.
KOiK01749.
OMAiGIECRTD.
OrthoDBiPOG091H064B.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam. 1 hit.
InterProiView protein in InterPro
IPR000860. HemC.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiView protein in Pfam
PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiView protein in PROSITE
PS00533. PORPHOBILINOGEN_DEAM. 1 hit.

Sequencei

Sequence statusi: Complete.

B4E8C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSETPAAGP QQAQPPATLT IASRESRLAM WQAEHVRDAL RKLYPACDVK
60 70 80 90 100
ILGMTTRGDQ ILDRTLSKVG GKGLFVKELE AALADGRADL AVHSLKDVPM
110 120 130 140 150
ALPDGFALAA IMEREDPRDA FVSNDYASLD ALPAGAVVGT SSLRREAMLR
160 170 180 190 200
SRYPHLEVLP LRGNLDTRLA KLDRGDYAAI ILAAAGLKRL GLEARIRALL
210 220 230 240 250
DVEASPPAAG QGALGIEIAA HRDDVAAWLA PLHDPRTALA VEAERMVSRA
260 270 280 290 300
LGGSCEVPLA AHAVWRAGEL YLTGRVSTTD GKRVLTAEEC GAVMTVADAL
310 320 330
ALGRAVSDEL EAQGALDIVQ ALLAGSQAAG KGDA
Length:334
Mass (Da):35,126
Last modified:September 23, 2008 - v1
Checksum:i2C054A5A2A1E9FD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA. Translation: CAR52932.1.
RefSeqiWP_012492813.1. NC_011000.1.

Genome annotation databases

EnsemblBacteriaiCAR52932; CAR52932; BCAL2630.
KEGGibcj:BCAL2630.
PATRICi19077173. VBIBurCen118154_2722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA. Translation: CAR52932.1.
RefSeqiWP_012492813.1. NC_011000.1.

3D structure databases

SMRiB4E8C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216591.BCAL2630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR52932; CAR52932; BCAL2630.
KEGGibcj:BCAL2630.
PATRICi19077173. VBIBurCen118154_2722.

Phylogenomic databases

eggNOGiENOG4105D6W. Bacteria.
COG0181. LUCA.
HOGENOMiHOG000228587.
KOiK01749.
OMAiGIECRTD.
OrthoDBiPOG091H064B.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00319.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam. 1 hit.
InterProiView protein in InterPro
IPR000860. HemC.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiView protein in Pfam
PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiView protein in PROSITE
PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEM3_BURCJ
AccessioniPrimary (citable) accession number: B4E8C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: March 15, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.