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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:BceJ2315_04640
ORF Names:BCAL0466
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001035 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000983851 – 330Methionyl-tRNA formyltransferaseAdd BLAST330

Proteomic databases

PRIDEiB4E7V8

Interactioni

Protein-protein interaction databases

STRINGi216591.BCAL0466

Structurei

3D structure databases

ProteinModelPortaliB4E7V8
SMRiB4E7V8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 124Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

B4E7V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHTLRVIFA GTPEFAAAAL AAIHEAGFPV PLVLTQPDRP AGRGMKLQAS
60 70 80 90 100
AVKRYAVEHG MTVAQPPSLR RAGKYPAEAA DAIELLRTTQ HDVMVVAAYG
110 120 130 140 150
LLLPQEVLDI PRAGCINIHA SLLPRWRGAA PIHRAIEAGD AETGVTLMQM
160 170 180 190 200
DVGLDTGAMI EEARIAIAPD DTTATLHDRL AADGARLIVD ALVRLERDGT
210 220 230 240 250
LPATPQPADG VTYAEKIGKH EAALDWRKPA DVLARQVRAF DPFPGGVATL
260 270 280 290 300
DGAAIKLWAA EPVAARGTMA NAAPGTIVEA APEGVVVACG SGALRVTQLQ
310 320 330
KPGGKRLPAR EFLAGSPLAA GQRFALPDVD
Length:330
Mass (Da):34,561
Last modified:September 23, 2008 - v1
Checksum:i7B1969B5AACD8D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA Translation: CAR50777.1
RefSeqiWP_006485789.1, NC_011000.1

Genome annotation databases

EnsemblBacteriaiCAR50777; CAR50777; BCAL0466
KEGGibcj:BCAL0466

Similar proteinsi

Entry informationi

Entry nameiFMT_BURCJ
AccessioniPrimary (citable) accession number: B4E7V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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