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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi230 – 237ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:BceJ2315_04210
ORF Names:BCAL0423
OrganismiBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))
Taxonomic identifieri216591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000001035 Componenti: Chromosome 1

Subcellular locationi

B4E7D1:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001219571 – 525Chromosomal replication initiator protein DnaAAdd BLAST525

Interactioni

Protein-protein interaction databases

STRINGi216591.BCAL0423.

Structurei

3D structure databases

SMRiB4E7D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235659.
KOiK02313.
OMAiREFNPLF.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
PANTHERiPTHR30050:SF2. PTHR30050:SF2. 1 hit.
PfamiView protein in Pfam
PF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
PRINTSiPR00051. DNAA.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiView protein in PROSITE
PS01008. DNAA. 1 hit.

Sequencei

Sequence statusi: Complete.

B4E7D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDFWQHCSA LLERELTPQQ YVTWIKPLAP VAFDASANTL SIAAPNRFKL
60 70 80 90 100
DWVKSQFSGR IADLAREFWN TPIEVQFVLD PKAGMRSAPA GAAPAAPRAP
110 120 130 140 150
LAPNGPAATV AAIAANLTAN ASAAPAAPAD VPMTPSAAAA RHLNADDADI
160 170 180 190 200
DLPSLPAHEA AAGRRTWRPG PGAAPANGGE ADSMYERSKL NPVLTFDNFV
210 220 230 240 250
TGKANQLARA AAIQVADNPG ISYNPLFLYG GVGLGKTHLI HAIGNQLLLD
260 270 280 290 300
KAGARIRYIH AEQYVSDVVK AYQRKAFDDF KRYYHSLDLL LIDDIQFFSG
310 320 330 340 350
KSRTQEEFFY AFEALVANKA QVIITSDTYP KEISGIDDRL ISRFDSGLTV
360 370 380 390 400
AIEPPELEMR VAILMRKAQS EGVNLSEDVA FFVAKHLRSN VRELEGALRK
410 420 430 440 450
ILAYSKFHGR EISIELTKEA LKDLLTVQNR QISVENIQKT VADFYNIKVA
460 470 480 490 500
DMYSKKRPAN IARPRQIAMY LAKELTQKSL PEIGELFGGR DHTTVLHAVR
510 520
KIADERSKDA QLNHELHVLE QTLKG
Length:525
Mass (Da):57,701
Last modified:September 23, 2008 - v1
Checksum:iCDE75EF38AA8A138
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM747720 Genomic DNA. Translation: CAR50734.1.

Genome annotation databases

EnsemblBacteriaiCAR50734; CAR50734; BCAL0423.
KEGGibcj:BCAL0423.

Similar proteinsi

Entry informationi

Entry nameiDNAA_BURCJ
AccessioniPrimary (citable) accession number: B4E7D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 25, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families