Reviewed, UniProtKB/Swiss-Prot B4E603 (AROB_BURCJ)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BceJ2315_02820
ORF Names:	BCAL0280

Organism

Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]

Taxonomic identifier

216591 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094472

Sequences

	Sequence		Length	Mass (Da)
	B4E603-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: AACB8495460BDA81	FASTA	359	37,951
	10 20 30 40 50 60 MITVNVDLGD RAYPIHIGAG LIGRTELFAP HIKGSSVTIV TNTTVDPLYG DALRAALAPL 70 80 90 100 110 120 GKRVSTVVLP DGEAYKNWET LNLIFDGLLT DHADRKTTLV ALGGGVVGDM TGFAAACYMR 130 140 150 160 170 180 GVPFIQVPTT LLSQVDSSVG GKTGINHPLG KNMIGAFYQP QAVIADIGAL TTLPDRELAA 190 200 210 220 230 240 GVAEVIKTGA IADAEFFDWI EANVEALNRR EPAALAHAVK RSCEIKASVV AADEREGGLR 250 260 270 280 290 300 AILNFGHTFG HAIEAGLGYG EWLHGEAVGC GMVMAGDLSV RLGLLDEASR QRLDAVIAAA 310 320 330 340 350 HLPTRAPALG DARYMDLMRV DKKAEAGAIK FILLKRFGDT LITQAPDEAV FATLAQTTR

References

[1]	"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen." Holden M.T.G. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM747720 Genomic DNA. Translation: CAR50590.1.
RefSeq	YP_002229446.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6933316.
GenomeReviews	Gene locus BceJ2315_02820 in contig AM747720_GR.
KEGG	bcj:BCAL0280.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG632303.
OMA	APESMDF.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BURCJ

Accession

Primary (citable) accession number: B4E603

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	February 9, 2010
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)