B4E3T1 (B4E3T1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ56374, highly similar to Probable phospholipid-transporting ATPase IF(EC 3.6.3.1) EMBL BAG65593.1
Organism	Homo sapiens (Human) EMBL BAG65593.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	892 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O + phospholipid(side 1) = ADP + phosphate + phospholipid(side 2). SAAS SAAS018303

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS023306
Ligand	ATP-binding SAAS SAAS023306 Magnesium SAAS SAAS018303 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS023306
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cation-transporting ATPase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4E3T1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 9429C934C85019D6	FASTA	892	101,803
	10 20 30 40 50 60 MNTFLIIYLV ILISEAVIST ILKYTWQAEE KWDEPWYNQK TEHQRNSSKI LRFISDFLAF 70 80 90 100 110 120 LVLYNFIIPI SLYVTVEMQK FLGSFFIGWD LDLYHEESDQ KAQVNTSDLN EELGQVEYVF 130 140 150 160 170 180 TDKTGTLTEN EMQFRECSIN GMKYQEINGR LVPEGPTPDS SEGNLSYLSS LSHLNNLSHL 190 200 210 220 230 240 TTSSSFRTSP ENETELIKEH DLFFKAVSLC HTVQISNVQT DCTGDGPWQS NLAPSQLEYY 250 260 270 280 290 300 ASSPDEKALV EAAARIGIVF IGNSEETMEV KTLGKLERYK LLHILEFDSD RRRMSVIVQA 310 320 330 340 350 360 PSGEKLLFAK GAESSILPKC IGGEIEKTRI HVDEFALKGL RTLCIAYRKF TSKEYEEIDK 370 380 390 400 410 420 RIFEARTALQ QREEKLAAVF QFIEKDLILL GATAVEDRLQ DKVRETIEAL RMAGIKVWVL 430 440 450 460 470 480 TGDKHETAVS VSLSCGHFHR TMNILELINQ KSDSECAEQL RQLARRITED HVIQHGLVVD 490 500 510 520 530 540 GTSLSLALRE HEKLFMEVCR NCSAVLCCRM APLQKAKVIR LIKISPEKPI TLAVGDGAND 550 560 570 580 590 600 VSMIQEAHVG IGIMGKEGRQ AARNSDYAIA RFKFLSKLLF VHGHFYYIRI ATLVQYFFYK 610 620 630 640 650 660 NVCFITPQFL YQFYCLFSQQ TLYDSVYLTL YNICFTSLPI LIYSLLEQHV DPHVLQNKPT 670 680 690 700 710 720 LYRDISKNRL LSIKTFLYWT ILGFSHAFIF FFGSYLLIGK DTSLLGNGQM FGNWTFGTLV 730 740 750 760 770 780 FTVMVITVTV KMALETHFWT WINHLVTWGS IIFYFVFSLF YGGILWPFLG SQNMYFVFIQ 790 800 810 820 830 840 LLSSGSAWFA IILMVVTCLF LDIIKKVFDR HLHPTSTEKA QLTETNAGIK CLDSMCCFPE 850 860 870 880 890 GEAACASVGR MLERVIGRCS PTHISRSWSA SDPFYTNDRS ILTLSTMDSS TC

References

[1]

"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Uterus EMBL BAG65593.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK304855 mRNA. Translation: BAG65593.1.
IPI	IPI00240793.
RefSeq	NP_055431.1. NM_014616.2.
UniGene	Hs.478429.
3D structure databases
ProteinModelPortal	B4E3T1.
ModBase	Search...
Protein-protein interaction databases
STRING	B4E3T1.
Proteomic databases
PRIDE	B4E3T1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	23200.
KEGG	hsa:23200.
Organism-specific databases
CTD	23200.
Phylogenomic databases
HOGENOM	HOG000202528.
HOVERGEN	HBG050601.
KO	K01530.
Gene expression databases
ArrayExpress	B4E3T1.
Bgee	B4E3T1.
Family and domain databases
Gene3D	3.40.1110.10. 2 hits. 3.40.50.1000. 2 hits.
InterPro	IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transp. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24092. PTHR24092. 1 hit.
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23200.
NextBio	44715.

Entry information

Entry name

B4E3T1_HUMAN

Accession

Primary (citable) accession number: B4E3T1

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.