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Protein

Phospholipid-translocating ATPase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. phospholipid-translocating ATPase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-translocating ATPaseSAAS annotation (EC:3.6.3.1SAAS annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiB4E3T1.

Expressioni

Gene expression databases

BgeeiB4E3T1.
ExpressionAtlasiB4E3T1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB4E3T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000202528.
HOVERGENiHBG050601.
KOiK01530.

Family and domain databases

Gene3Di3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR030362. ATP11B.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF57. PTHR24092:SF57. 1 hit.
PfamiPF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E3T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTFLIIYLV ILISEAVIST ILKYTWQAEE KWDEPWYNQK TEHQRNSSKI
60 70 80 90 100
LRFISDFLAF LVLYNFIIPI SLYVTVEMQK FLGSFFIGWD LDLYHEESDQ
110 120 130 140 150
KAQVNTSDLN EELGQVEYVF TDKTGTLTEN EMQFRECSIN GMKYQEINGR
160 170 180 190 200
LVPEGPTPDS SEGNLSYLSS LSHLNNLSHL TTSSSFRTSP ENETELIKEH
210 220 230 240 250
DLFFKAVSLC HTVQISNVQT DCTGDGPWQS NLAPSQLEYY ASSPDEKALV
260 270 280 290 300
EAAARIGIVF IGNSEETMEV KTLGKLERYK LLHILEFDSD RRRMSVIVQA
310 320 330 340 350
PSGEKLLFAK GAESSILPKC IGGEIEKTRI HVDEFALKGL RTLCIAYRKF
360 370 380 390 400
TSKEYEEIDK RIFEARTALQ QREEKLAAVF QFIEKDLILL GATAVEDRLQ
410 420 430 440 450
DKVRETIEAL RMAGIKVWVL TGDKHETAVS VSLSCGHFHR TMNILELINQ
460 470 480 490 500
KSDSECAEQL RQLARRITED HVIQHGLVVD GTSLSLALRE HEKLFMEVCR
510 520 530 540 550
NCSAVLCCRM APLQKAKVIR LIKISPEKPI TLAVGDGAND VSMIQEAHVG
560 570 580 590 600
IGIMGKEGRQ AARNSDYAIA RFKFLSKLLF VHGHFYYIRI ATLVQYFFYK
610 620 630 640 650
NVCFITPQFL YQFYCLFSQQ TLYDSVYLTL YNICFTSLPI LIYSLLEQHV
660 670 680 690 700
DPHVLQNKPT LYRDISKNRL LSIKTFLYWT ILGFSHAFIF FFGSYLLIGK
710 720 730 740 750
DTSLLGNGQM FGNWTFGTLV FTVMVITVTV KMALETHFWT WINHLVTWGS
760 770 780 790 800
IIFYFVFSLF YGGILWPFLG SQNMYFVFIQ LLSSGSAWFA IILMVVTCLF
810 820 830 840 850
LDIIKKVFDR HLHPTSTEKA QLTETNAGIK CLDSMCCFPE GEAACASVGR
860 870 880 890
MLERVIGRCS PTHISRSWSA SDPFYTNDRS ILTLSTMDSS TC
Length:892
Mass (Da):101,803
Last modified:September 23, 2008 - v1
Checksum:i9429C934C85019D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304855 mRNA. Translation: BAG65593.1.
RefSeqiNP_055431.1. NM_014616.2.
UniGeneiHs.478429.

Genome annotation databases

GeneIDi23200.
KEGGihsa:23200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304855 mRNA. Translation: BAG65593.1.
RefSeqiNP_055431.1. NM_014616.2.
UniGeneiHs.478429.

3D structure databases

ProteinModelPortaliB4E3T1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB4E3T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23200.
KEGGihsa:23200.

Organism-specific databases

CTDi23200.

Phylogenomic databases

HOGENOMiHOG000202528.
HOVERGENiHBG050601.
KOiK01530.

Miscellaneous databases

GenomeRNAii23200.
NextBioi44715.

Gene expression databases

BgeeiB4E3T1.
ExpressionAtlasiB4E3T1. baseline and differential.

Family and domain databases

Gene3Di3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR030362. ATP11B.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF57. PTHR24092:SF57. 1 hit.
PfamiPF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: UterusImported.

Entry informationi

Entry nameiB4E3T1_HUMAN
AccessioniPrimary (citable) accession number: B4E3T1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 4, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.