B4E3T0 (B4E3T0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Progesterone receptor Ensembl ENSP00000436561

Submitted name:
cDNA FLJ51472, highly similar to Progesterone receptor EMBL BAG65592.1

Gene names

Name:

PGR Ensembl ENSP00000436561

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAG65592.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS000536
Cellular component	Nucleus SAAS SAAS000536
Domain	Zinc-finger SAAS SAAS000536
Ligand	DNA-binding SAAS SAAS000536 Metal-binding Zinc
Molecular function	Receptor EMBL BAG65592.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	epithelial cell maturation Inferred from electronic annotation. Source: Compara ovulation from ovarian follicle Inferred from electronic annotation. Source: Compara progesterone receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara tertiary branching involved in mammary gland duct morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4E3T0 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 4496D6B5A4EC95FD	FASTA	339	38,798
	10 20 30 40 50 60 MEGQHNYLCA GRNDCIVDKI RRKNCPACRL RKCCQAGMVL GGRKFKKFNK VRVVRALDAV 70 80 90 100 110 120 ALPQPVGVPN ESQALSQRFT FSPGQDIQLI PPLINLLMSI EPDVIYAGHD NTKPDTSSSL 130 140 150 160 170 180 LTSLNQLGER QLLSVVKWSK SLPGFRNLHI DDQITLIQYS WMSLMVFGLG WRSYKHVSGQ 190 200 210 220 230 240 MLYFAPDLIL NEQRMKESSF YSLCLTMWQI PQEFVKLQVS QEEFLCMKVL LLLNTIPLEG 250 260 270 280 290 300 LRSQTQFEEM RSSYIRELIK AIGLRQKGVV SSSQRFYQLT KLLDNLHDLV KQLHLYCLNT 310 320 330 FIQSRALSVE FPEMMSEVIA AQLPKILAGM VKPLLFHKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Uterus EMBL BAG65592.1.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP001533 Genomic DNA. No translation available. AK304853 mRNA. Translation: BAG65592.1.
IPI	IPI00219021.
RefSeq	NP_001258091.1. NM_001271162.1.
UniGene	Hs.32405. Hs.742403.
3D structure databases
SMR	B4E3T0. Positions 1-46, 89-339.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000534013; ENSP00000436561; ENSG00000082175.
GeneID	5241.
KEGG	hsa:5241.
UCSC	uc001pgg.2. human.
Organism-specific databases
CTD	5241.
HGNC	HGNC:8910. PGR.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG007583.
KO	K08556.
Gene expression databases
ArrayExpress	B4E3T0.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00398. STRDHORMONER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5241.
NextBio	35477621.

Entry information

Entry name

B4E3T0_HUMAN

Accession

Primary (citable) accession number: B4E3T0

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.