B4E3P0 (B4E3P0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
ATP-citrate synthase Ensembl ENSP00000445349

Submitted name:
cDNA FLJ55447, highly similar to ATP-citrate synthase (EC 2.3.3.8) EMBL BAG65552.1

Gene names

Name:

ACLY Ensembl ENSP00000445349

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAG65552.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	830 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	ATP citrate synthase activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4E3P0 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 1F3758EEAACA3730	FASTA	830	91,099
	10 20 30 40 50 60 MSAKAISEQT GKELLYKFIC TTSAIQNRFK YARVTPDTDW ARLLQDHPWL LSQNLVVKPD 70 80 90 100 110 120 QLIKRRGKLG LVGVNLTLDG VKSWLKPRLG QEATGIVRAI RDYQGPLKEH EVTIFVRRGG 130 140 150 160 170 180 PNYQEGLRVM GEVGKTTGIP IHVFGTETHM TAIVGMALGH RPIPNQPPTA AHTANFLLNA 190 200 210 220 230 240 SGSTSTPAPS RTASFSESRA DEVAPAKKAK PAMPQGKSTT LFSRHTKAIV WGMQTRAVQG 250 260 270 280 290 300 MLDFDYVCSR DEPSVAAMVY PFTGDHKQKF YWGHKEILIP VFKNMADAMR KHPEVDVLIN 310 320 330 340 350 360 FASLRSAYDS TMETMNYAQI RTIAIIAEGI PEALTRKLIK KADQKGVTII GPATVGGIKP 370 380 390 400 410 420 GCFKIGNTGG MLDNILASKL YRPGSVAYVS RSGGMSNELN NIISRTTDGV YEGVAIGGDR 430 440 450 460 470 480 YPGSTFMDHV LRYQDTPGVK MIVVLGEIGG TEEYKICRGI KEGRLTKPIV CWCIGTCATM 490 500 510 520 530 540 FSSEVQFGHA GACANQASET AVAKNQALKE AGVFVPRSFD ELGEIIQSVY EDLVANGVIV 550 560 570 580 590 600 PAQEVPPPTV PMDYSWAREL GLIRKPASFM TSICDERGQE LIYAGMPITE VFKEEMGIGG 610 620 630 640 650 660 VLGLLWFQKR LPKYSCQFIE MCLMVTADHG PAVSGAHNTI ICARAGKDLV SSLTSGLLTI 670 680 690 700 710 720 GDRFGGALDA AAKMFSKAFD SGIIPMEFVN KMKKEGKLIM GIGHRVKSIN NPDMRVQILK 730 740 750 760 770 780 DYVRQHFPAT PLLDYALEVE KITTSKKPNL ILNVDGLIGV AFVDMLRNCG SFTREEADEY 790 800 810 820 830 IDIGALNGIF VLGRSMGFIG HYLDQKRLKQ GLYRHPWDDI SYVLPEHMSM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Uterus EMBL BAG65552.1.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC091172 Genomic DNA. No translation available. AK304802 mRNA. Translation: BAG65552.1.
IPI	IPI00935456.
UniGene	Hs.387567.
3D structure databases
SMR	B4E3P0. Positions 2-549, 640-804.
ModBase	Search...
Proteomic databases
PRIDE	B4E3P0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000537919; ENSP00000445349; ENSG00000131473.
UCSC	uc010wfy.2. human.
Organism-specific databases
HGNC	HGNC:115. ACLY.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG003318.
Gene expression databases
ArrayExpress	B4E3P0.
Family and domain databases
Gene3D	1.10.230.10. 1 hit. 3.40.50.261. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR016143. Citrate_synth-like_sm_a-sub. IPR002020. Citrate_synthase-like. IPR016141. Citrate_synthase-like_core. IPR003781. CoA-bd. IPR005810. CoA_lig_alpha. IPR005811. CoA_ligase. IPR016040. NAD(P)-bd_dom. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Pfam	PF00285. Citrate_synt. 1 hit. PF02629. CoA_binding. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
SUPFAM	SSF48256. Citrate_synthase_core. 1 hit.
PROSITE	PS01216. SUCCINYL_COA_LIG_1. 1 hit. PS00399. SUCCINYL_COA_LIG_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ACLY. human.
NextBio	35477588.

Entry information

Entry name

B4E3P0_HUMAN

Accession

Primary (citable) accession number: B4E3P0

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.