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Protein
Submitted name:

Ubiquitin carboxyl-terminal hydrolase 28

Gene

USP28

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin carboxyl-terminal hydrolase 28Imported
Submitted name:
cDNA FLJ58236, highly similar to Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15)Imported
Gene namesi
Name:USP28Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12625. USP28.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000048028.

PTM / Processingi

Proteomic databases

EPDiB4E3L3.
MaxQBiB4E3L3.
PeptideAtlasiB4E3L3.
PRIDEiB4E3L3.

Expressioni

Gene expression databases

BgeeiENSG00000048028.
ExpressionAtlasiB4E3L3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000003302.

Structurei

3D structure databases

ProteinModelPortaliB4E3L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 525USPInterPro annotationAdd BLAST489

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili280 – 307Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1863. Eukaryota.
COG5077. LUCA.
GeneTreeiENSGT00390000016082.
HOGENOMiHOG000007956.
HOVERGENiHBG056030.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E3L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEATSAETK RSKRKRCEVW GENPNPNDWR RVDGWPVGLK NVGNTCWFSA
60 70 80 90 100
VIQSLFQLPE FRRLVLSYSL PQNVLENCRS HTEKRNIMFM QELQYLFALM
110 120 130 140 150
MGSNRKFVDP SAALDLLKGA FRSSEEQQQD VSEFTHKLLD WLEDAFQLAV
160 170 180 190 200
NVNSPRNKSE NPMVQLFYGT FLTEGVREGK PFCNNETFGQ YPLQVNGYRN
210 220 230 240 250
LDECLEGAMV EGDVELLPSD HSVKYGQERW FTKLPPVLTF ELSRFEFNQS
260 270 280 290 300
LGQPEKIHNK LEFPQIIYMD RYMYRSKELI RNKRECIRKL KEEIKILQQK
310 320 330 340 350
LERYVKYGSG PARFPLPDML KYVIEFASTK PASESCPPES DTHMTLPLSS
360 370 380 390 400
VHCSVSDQTS KESTSTESSS QDVESTFSSP EDSLPKSKPL TSSRSSMEMP
410 420 430 440 450
SQPAPRTVTD EEINFVKTCL QRWRSEIEQD IQDLKTCIAS TTQTIEQMYC
460 470 480 490 500
DPLLRQVPYR LHAVLVHEGQ ANAGHYWAYI YNQPRQSWLK YNDISVTESS
510 520 530 540 550
WEEVERDSYG GLRNVSAYCL MYINDKLPYF NAEAAPTESD QMSEVEALSV
560 570 580 590 600
ELKHYIQEDN WRFEQEVEEW EEEQSCKIPQ MESSTNSSSQ DYSTSQEPSV
610 620 630 640 650
ASSHGVRCLS SEHAVIVKEQ TAQAIANTAR AYEKSGVEAA LSEAFHEEYS
660 670 680 690 700
RLYQLAKETP TSHSDPRLQH VLVYFFQNEA PKRVVERTLL EQFADKNLSY
710 720 730 740 750
DERSISIMKV AQAKLKEIGP DDMNMEEYKK WHEDYSLFRK VSVYLLTGLE
760 770 780 790 800
LYQKGKYQEA LSYLVYAYQS NAALLMKGPR RGVKESVIAL YRRKCLLELN
810 820 830 840 850
AKAASLFETN DDHSVTEGIN VMNELIIPCI HLIINNDISK DDLDAIEVMR
860 870 880 890 900
NHWCSYLGQD IAENLQLCLG EFLPRLLDPS AEIIVLKEPP TIRPNSPYDL
910 920
CSRFAAVMES IQGVSTVTVK
Length:920
Mass (Da):105,817
Last modified:September 23, 2008 - v1
Checksum:i6ABA1B1182B6D8E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001874 Genomic DNA. No translation available.
AP003170 Genomic DNA. No translation available.
KF455523 Genomic DNA. No translation available.
KF459544 Genomic DNA. No translation available.
AK304770 mRNA. Translation: BAG65525.1.
RefSeqiNP_001287958.1. NM_001301029.1.
UniGeneiHs.503891.

Genome annotation databases

EnsembliENST00000545540; ENSP00000444991; ENSG00000048028.
GeneIDi57646.
UCSCiuc010rwy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001874 Genomic DNA. No translation available.
AP003170 Genomic DNA. No translation available.
KF455523 Genomic DNA. No translation available.
KF459544 Genomic DNA. No translation available.
AK304770 mRNA. Translation: BAG65525.1.
RefSeqiNP_001287958.1. NM_001301029.1.
UniGeneiHs.503891.

3D structure databases

ProteinModelPortaliB4E3L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000003302.

Proteomic databases

EPDiB4E3L3.
MaxQBiB4E3L3.
PeptideAtlasiB4E3L3.
PRIDEiB4E3L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000545540; ENSP00000444991; ENSG00000048028.
GeneIDi57646.
UCSCiuc010rwy.3. human.

Organism-specific databases

CTDi57646.
HGNCiHGNC:12625. USP28.
OpenTargetsiENSG00000048028.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1863. Eukaryota.
COG5077. LUCA.
GeneTreeiENSGT00390000016082.
HOGENOMiHOG000007956.
HOVERGENiHBG056030.

Miscellaneous databases

ChiTaRSiUSP28. human.
GenomeRNAii57646.

Gene expression databases

BgeeiENSG00000048028.
ExpressionAtlasiB4E3L3. baseline and differential.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4E3L3_HUMAN
AccessioniPrimary (citable) accession number: B4E3L3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.