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Protein
Submitted name:

cDNA FLJ59657, highly similar to 2-oxoglutarate dehydrogenase E1 component, mitochondrial (EC 1.2.4.2)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ59657, highly similar to 2-oxoglutarate dehydrogenase E1 component, mitochondrial (EC 1.2.4.2)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31910.

PTM / Processingi

Proteomic databases

PaxDbiB4E3E9.
PRIDEiB4E3E9.

Expressioni

Gene expression databases

GenevisibleiB4E3E9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000222673.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini446 – 660215Transket_pyrInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0450. Eukaryota.
COG0567. LUCA.
HOVERGENiHBG001892.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR031717. KGD_C.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF16870. OxoGdeHyase_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

B4E3E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIWTPPCPL TLSHPQTNLG SMAWMSLTST RSSTCPPPLS SGDRNQHFLC
60 70 80 90 100
GRSSVGWRFE EFLQRKWSSE KRFGLEGCEV LIPALKTIID KSSENGVDYV
110 120 130 140 150
IMGMPHRGRL NVLANVIRKE LEQIFCQFDS KLEAADEGSG DVKYHLGMYH
160 170 180 190 200
RRINRVTDRN ITLSLVANPS HLEAADPVVM GKTKAEQFYC GDTEGKKVMS
210 220 230 240 250
ILLHGDAAFA GQGIVYETFH LSDLPSYTTH GTVHVVVNNQ IGFTTDPRMA
260 270 280 290 300
RSSPYPTDVA RVVNAPIFHV NSDDPEAVMY VCKVAAEWRS TFHKDVVVDL
310 320 330 340 350
VCYRRNGHNE MDEPMFTQPL MYKQIRKQKP VLQKYAELLV SQGVVNQPEY
360 370 380 390 400
EEEISKYDKI CEEAFARSKD EKILHIKHWL DSPWPGFFTL DGQPRSMSCP
410 420 430 440 450
STGLTEDILT HIGNVASSVP VENFTIHGGL SRILKTRGEM VKNRTVDWAL
460 470 480 490 500
AEYMAFGSLL KEGIHIRLSG QDVERGTFSH RHHVLHDQNV DKRTCIPMNH
510 520 530 540 550
LWPNQAPYTV CNSSLSEYGV LGFELGFAMA SPNALVLWEA QFGDFHNTAQ
560 570 580 590 600
CIIDQFICPG QAKWVRQNGI VLLLPHGMEG MGPEHSSARP ERFLQMCNDD
610 620 630 640 650
PDVLPDLKEA NFDINQLYDC NWVVVNCSTP GNFFHVLRRQ ILLPFRKPLI
660 670 680 690 700
IFTPKSLLRH PEARSSFDEM LPGTHFQRVI PEDGPAAQNP ENVKRLLFCT
710 720 730 740 750
GKVYYDLTRE RKARDMVGQV AITRIEQLSP FPFDLLLKEV QKYPNAELAW
760 770 780 790 800
CQEEHKNQGY YDYVKPRLRT TISRAKPVWY AGRDPAAAPA TGNKKTHLTE
810
LQRLLDTAFD LDVFKNFS
Length:818
Mass (Da):92,840
Last modified:September 23, 2008 - v1
Checksum:iDD846E3E57885C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304690 mRNA. Translation: BAG65461.1.
RefSeqiNP_001158508.1. NM_001165036.1.
NP_002532.2. NM_002541.3.
UniGeneiHs.488181.

Genome annotation databases

GeneIDi4967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304690 mRNA. Translation: BAG65461.1.
RefSeqiNP_001158508.1. NM_001165036.1.
NP_002532.2. NM_002541.3.
UniGeneiHs.488181.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000222673.

Proteomic databases

PaxDbiB4E3E9.
PRIDEiB4E3E9.

Protocols and materials databases

DNASUi4967.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4967.

Organism-specific databases

CTDi4967.
PharmGKBiPA31910.

Phylogenomic databases

eggNOGiKOG0450. Eukaryota.
COG0567. LUCA.
HOVERGENiHBG001892.

Miscellaneous databases

GenomeRNAii4967.

Gene expression databases

GenevisibleiB4E3E9. HS.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR031717. KGD_C.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF16870. OxoGdeHyase_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: UterusImported.

Entry informationi

Entry nameiB4E3E9_HUMAN
AccessioniPrimary (citable) accession number: B4E3E9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.