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Protein

Myeloid differentiation primary response protein MyD88

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunityUniRule annotation, Inflammatory responseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid differentiation primary response protein MyD88UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiB4E3D6.

Interactioni

Subunit structurei

Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 285TIRInterPro annotationAdd BLAST138

Phylogenomic databases

HOVERGENiHBG052547.

Family and domain databases

CDDicd08312. Death_MyD88. 1 hit.
Gene3Di3.40.50.10140. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR034249. MyD88_Death.
IPR017281. Myelin_different_resp_MyD88.
IPR000157. TIR_dom.
PfamiView protein in Pfam
PF01582. TIR. 1 hit.
PIRSFiPIRSF037756. MyD88. 1 hit.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00255. TIR. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiView protein in PROSITE
PS50104. TIR. 1 hit.

Sequencei

Sequence statusi: Complete.

B4E3D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGGPGAGS AAPVSSTSSL PLAALNMRVR RRLSLFLNVR TQVAADWTAL
60 70 80 90 100
AEEMDFEYLE IRQLETQADP TGASVGRLLE LLTKLGRDDV LLELGPSIEE
110 120 130 140 150
DCQKYILKQQ QEEAEKPLQV AAVDSSVPRT AELAGITTLD DPLGHMPERF
160 170 180 190 200
DAFICYCPSD IQFVQEMIRQ LEQTNYRLKL CVSDRDVLPG TCVWSIASEL
210 220 230 240 250
IEKRCRRMVV VVSDDYLQSK ECDFQTKFAL SLSPGAHQKR LIPIKYKAMK
260 270 280
KEFPSILRFI TVCDYTNPCT KSWFWTRLAK ALSLP
Length:285
Mass (Da):31,983
Last modified:September 23, 2008 - v1
Checksum:i73F8770D38B829DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304676 mRNA. Translation: BAG65448.1.
UniGeneiHs.82116.

Similar proteinsi

Entry informationi

Entry nameiB4E3D6_HUMAN
AccessioniPrimary (citable) accession number: B4E3D6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: August 30, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.