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Protein
Submitted name:

cDNA FLJ61569, highly similar to 5-hydroxytryptamine 3 receptor

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ61569, highly similar to 5-hydroxytryptamine 3 receptorImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei249 – 272HelicalSequence analysisAdd BLAST24
Transmembranei284 – 305HelicalSequence analysisAdd BLAST22
Transmembranei311 – 333HelicalSequence analysisAdd BLAST23
Transmembranei458 – 481HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500280408830 – 484Sequence analysisAdd BLAST455

Proteomic databases

PRIDEiB4E398.

Expressioni

Gene expression databases

GenevisibleiB4E398. HS.

Structurei

3D structure databases

ProteinModelPortaliB4E398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 248Neur_chan_LBDInterPro annotationAdd BLAST207
Domaini255 – 474Neur_chan_membInterPro annotationAdd BLAST220

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOGENOMiHOG000241519.
HOVERGENiHBG106638.
KOiK04819.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008133. 5HT3_rcpt_A.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01709. 5HT3ARECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKLAMLLW VQQALLALLL PTLLAQGEAR RSRNTTRPAL LRLSDYLLTN
60 70 80 90 100
YRKGVRPVRD WRKPTTVSID VIVYAILNVD EKNQVLTTYI WYRQYWTDEF
110 120 130 140 150
LQWNPEDFDN ITKLSIPTDS IWVPDILINE FVDVGKSPNI PYVYIRHQGE
160 170 180 190 200
VQNYKPLQVV TACSLDIYNF PFDVQNCSLT FTSWLHTIQD INISLWRLPE
210 220 230 240 250
KVKSDRSVFM NQGEWELLGV LPYFREFSME SSNYYAEMKF YVVIRRRPLF
260 270 280 290 300
YVVSLLLPSI FLMVMDIVGF YLPPNSGERV SFKITLLLGY SVFLIIVSDT
310 320 330 340 350
LPATAIGTPL IGVYFVVCMA LLVISLAETI FIVRLVHKQD LQQPVPAWLR
360 370 380 390 400
HLVLERIAWL LCLREQSTSQ RPPATSQATK TDDCSAMGNH CSHMGGPQDF
410 420 430 440 450
EKSPRDRCSP PPPPREASLA VCGLLQELSS IRQFLERRDE IREVARDWLR
460 470 480
VGSVLDKLLF HIYLLAVLAY SITLVMLWSI WQYA
Length:484
Mass (Da):55,922
Last modified:September 23, 2008 - v1
Checksum:iC941CD97007BCB4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304630 mRNA. Translation: BAG65410.1.
RefSeqiNP_000860.2. NM_000869.5.
NP_998786.2. NM_213621.3.
UniGeneiHs.413899.

Genome annotation databases

GeneIDi3359.
KEGGihsa:3359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304630 mRNA. Translation: BAG65410.1.
RefSeqiNP_000860.2. NM_000869.5.
NP_998786.2. NM_213621.3.
UniGeneiHs.413899.

3D structure databases

ProteinModelPortaliB4E398.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB4E398.

Protocols and materials databases

DNASUi3359.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3359.
KEGGihsa:3359.

Organism-specific databases

CTDi3359.
PharmGKBiPA29555.

Phylogenomic databases

HOGENOMiHOG000241519.
HOVERGENiHBG106638.
KOiK04819.

Miscellaneous databases

GenomeRNAii3359.

Gene expression databases

GenevisibleiB4E398. HS.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008133. 5HT3_rcpt_A.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01709. 5HT3ARECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4E398_HUMAN
AccessioniPrimary (citable) accession number: B4E398
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 5, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.