ID   B4E2X3_HUMAN            Unreviewed;       698 AA.
AC   B4E2X3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   SubName: Full=cDNA FLJ56024 {ECO:0000313|EMBL:BAG65285.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG65285.1};
RN   [1] {ECO:0000313|EMBL:BAG65285.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Uterus {ECO:0000313|EMBL:BAG65285.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AK304471; BAG65285.1; -; mRNA.
DR   AlphaFoldDB; B4E2X3; -.
DR   IntAct; B4E2X3; 3.
DR   MaxQB; B4E2X3; -.
DR   PeptideAtlas; B4E2X3; -.
DR   ProteomicsDB; 5862; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR025714; Methyltranfer_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; NF037959; MFS_SpdSyn; 1.
DR   PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR   PANTHER; PTHR12176:SF88; SPERMINE_SPERMIDINE SYNTHASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G08500); 1.
DR   Pfam; PF13847; Methyltransf_31; 1.
DR   Pfam; PF01564; Spermine_synth; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE   2: Evidence at transcript level;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          46..161
FT                   /note="Methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF13847"
FT   REGION          432..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   698 AA;  78688 MW;  E7122FFB3DE35D9F CRC64;
     MRAFVVSREF GSVDYWEKFF QQRGKKAFEW YGTYLELCGV LHKYIKPREK VLVIGCGNSE
     LSEQLYDVGY RDIVNIDISE VVIKQMKECN ATRRPQMSFL KMDMTQMEFP DASFQVVLDK
     GTLDAVLTDE EEKTLQQVDR MLAEVGRVLQ VGGRYLCISL AQAHILKKAV GHFSREGWMV
     RVHQVANSQD QVLEAEPQFS LPVFAFIMTK FRPVPGSALQ IFELCAQEQR KPVRLESAER
     LAEAVQERQQ YAWLCSQLRR KARLGSVSLD LCDGDTGEPR YTLHVVDSPT VKPSRDNHFA
     IFIIPQGRET EWLFGMDEGR KQLAASAGFR RLITVALHRG QQYESMDHIQ AELSARVMEL
     APAGMPTQQQ VPFLSVGGDI GVRTVQHQDC SPLSGDYVIE DVQGDDKRYF RRLIFLSNRN
     VVQSEARLLK DVSHKAQKKR KKDRKKQRPA DAEDLPAAPG QSIDKSYLCC EHHKAMIAGL
     ALLRNPELLL EIPLALLVVG LGGGSLPLFV HDHFPKSCID AVEIDPSMLE VATQWFGFSQ
     SDRMKVHIAD GLDYIASLAG GGEARPCYDV IMFDVDSKDP TLGMSCPPPA FVEQSFLQKV
     KSILTPEGVF ILNLVCRDLG LKDSVLAGLK AVFPLLYVRR IEGEVNEILF CQLHPEQKLA
     TPELLETAQA LERTLRKPGR GWDDTYVLSD MLKTVKIV
//