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Protein
Submitted name:

cDNA FLJ58780, highly similar to Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant LAMP2B, mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ58780, highly similar to Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant LAMP2B, mRNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei328 – 351HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

LysosomePROSITE-ProRule annotation, Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106 ↔ 142PROSITE-ProRule annotation
Disulfide bondi284 ↔ 321PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

EPDiB4E2S7.
MaxQBiB4E2S7.
PeptideAtlasiB4E2S7.
PRIDEiB4E2S7.

Expressioni

Gene expression databases

BgeeiENSG00000005893.

Structurei

3D structure databases

ProteinModelPortaliB4E2S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG052303.

Family and domain databases

InterProiView protein in InterPro
IPR002000. Lysosome-assoc_membr_glycop.
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiView protein in Pfam
PF01299. Lamp. 1 hit.
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiView protein in PROSITE
PS51407. LAMP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

B4E2S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTVRYETT NKTYKTVTIS DHGTVTYNGS ICGDDQNGPK IAVQFGPGFS
60 70 80 90 100
WIANFTKAAS TYSIDSVSFS YNTGDNTTFP DAEDKGILTV DELLAIRIPL
110 120 130 140 150
NDLFRCNSLS TLEKNDVVQH YWDVLVQAFV QNGTVSTNEF LCDKDKTSTV
160 170 180 190 200
APTIHTTVPS PTTTPTPKEK PEAGTYSVNN GNDTCLLATM GLQLNITQDK
210 220 230 240 250
VASVININPN TTHSTGSCRS HTALLRLNSS TIKYLDFVFA VKNENRFYLK
260 270 280 290 300
EVNISMYLVN GSVFSIANNN LSYWDAPLGS SYMCNKEQTV SVSGAFQINT
310 320 330 340 350
FDLRVQPFNV TQGKYSTAQE CSLDDDTILI PIIVGAGLSG LIIVIVIAYV
360
IGRRKSYAGY QTL
Length:363
Mass (Da):39,812
Last modified:September 23, 2008 - v1
Checksum:i0483420BCA755CAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304405 mRNA. Translation: BAG65239.1.
UniGeneiHs.496684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304405 mRNA. Translation: BAG65239.1.
UniGeneiHs.496684.

3D structure databases

ProteinModelPortaliB4E2S7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiB4E2S7.
MaxQBiB4E2S7.
PeptideAtlasiB4E2S7.
PRIDEiB4E2S7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG052303.

Miscellaneous databases

ChiTaRSiLAMP2. human.

Gene expression databases

BgeeiENSG00000005893.

Family and domain databases

InterProiView protein in InterPro
IPR002000. Lysosome-assoc_membr_glycop.
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiView protein in Pfam
PF01299. Lamp. 1 hit.
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiView protein in PROSITE
PS51407. LAMP_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB4E2S7_HUMAN
AccessioniPrimary (citable) accession number: B4E2S7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: February 15, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.