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Protein
Submitted name:

cDNA FLJ60405, highly similar to Rho guanine nucleotide exchange factor 12

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ60405, highly similar to Rho guanine nucleotide exchange factor 12Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB4E2K6.

Expressioni

Gene expression databases

BgeeiB4E2K6.
GenevisibleiB4E2K6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000380942.

Structurei

3D structure databases

ProteinModelPortaliB4E2K6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000034046.
HOVERGENiHBG050571.
KOiK07532.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR016137. RGS.
IPR015212. RGS-like_dom.
IPR015721. RhoGEF-like.
[Graphical view]
PANTHERiPTHR22825. PTHR22825. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B4E2K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTGLV
60 70 80 90 100
QRCVIIQKDD NGFGLTVSGD NPVFVQSVKE DGAAMRAGVQ TGDRIIKVNG
110 120 130 140 150
TLVTHSNHLE VVKLIKSGSY VALTVQGRPP GSPQIPLADS EVEPSVIGHM
160 170 180 190 200
SPIMTSPHSP GASGNMERIT SPVLMGEENN VVHNQKVEIL RKMLQKEQER
210 220 230 240 250
LQLLQEDYNR TPAQRLLKEI QEAKKHIPQL QEQLSKATGS AQDGAVVTPS
260 270 280 290 300
RPLGDTLTVS EAETDPGDVL GRTDCSSGDA SRPSSDNADS PKSGPKERIY
310 320 330 340 350
LEENPEKSET IQDTDTQSLV GSPSTRIAPH IIGAEDDDFG TEHEQINGQC
360 370 380 390 400
SCFQSIELLK SRPAHLAVFL HHVVSQFDPA TLLCYLYSDL YKHTNSKETR
410 420 430 440 450
RIFLEFHQFF LDRSAHLKVS VPDEMSADLE KRRPELIPED LHRHYIQTMQ
460 470 480 490 500
ERVHPEVQRH LEDFRQKRSM GLTLAESELT KLDAERDKDR LTLEKERTCA
510 520 530 540 550
EQIVAKIEEV LMTAQAVEED KSSTMQYVIL MYMKHLGVKV KEPRNLEHKR
560 570 580 590 600
GRIGFLPKIK QSMKKDKEGE EKGKRRGFPS ILGPPRRPSR HDNSAIGRAM
610 620 630 640 650
ELQKARHPKH LSTPSSVSPE PQDSAKLRQS GLANEGTDAG YLPANSMSSV
660 670 680 690 700
ASGASFSQEG GKENDTGSKQ VGETSAPGDT LDGTPRTLNT VFDFPPPPLD
710 720 730 740 750
QVQEEECEVE RVTEHGTPKP FRKFDSVAFG ESQSEDEQFE NDLETDPPNW
760 770 780 790 800
QQLVSREVLL GLKPCEIKRQ EVINELFYTE RAHVRTLKVL DQVFYQRVSR
810 820 830 840 850
EGILSPSELR KIFSNLEDIL QLHIGLNEQM KAVRKRNETS VIDQIGEDLL
860 870 880 890 900
TWFSGPGEEK LKHAAATFCS NQPFALEMIK SRQKKDSRFQ TFVQDAESNP
910 920 930 940 950
LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK YTEWPTEREK VKKAADHCRQ
960 970 980 990 1000
ILNYVNQAVK EAENKQRLED YQRRLDTSSL KLSEYPNVEE LRNLDLTKRK
1010 1020 1030 1040 1050
MIHEGPLVWK VNRDKTIDLY TLLLEDILVL LQKQDDRLVL RCHSKILAST
1060 1070 1080 1090 1100
ADSKHTFSPV IKLSTVLVRQ VATDNKALFV ISMSDNGAQI YELVAQTVSE
1110 1120 1130 1140 1150
KTVWQDLICR MAASVKEQST KPIPLPQSTP GEGDNDEEDP SKLKEEQHGI
1160 1170 1180 1190 1200
SVTGLQSPDR DLGLESTLIS SKPQSHSLST SGKSEVRDLF VAERQFAKEQ
1210 1220 1230 1240 1250
HTDGTLKEVG EDYQIAIPDS HLPVSEERWA LDALRNLGLL KQLLVQQLGL
1260 1270
TEKSVQEDWQ HFPRYRTASQ GPQTDSVI
Length:1,278
Mass (Da):143,947
Last modified:September 23, 2008 - v1
Checksum:iA6279845201B370A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1278 – 12781Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304316 mRNA. Translation: BAG65168.1.
RefSeqiNP_001185594.1. NM_001198665.1.
NP_056128.1. NM_015313.2.
UniGeneiHs.24598.

Genome annotation databases

GeneIDi23365.
KEGGihsa:23365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304316 mRNA. Translation: BAG65168.1.
RefSeqiNP_001185594.1. NM_001198665.1.
NP_056128.1. NM_015313.2.
UniGeneiHs.24598.

3D structure databases

ProteinModelPortaliB4E2K6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000380942.

Proteomic databases

PRIDEiB4E2K6.

Protocols and materials databases

DNASUi23365.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23365.
KEGGihsa:23365.

Organism-specific databases

CTDi23365.

Phylogenomic databases

HOGENOMiHOG000034046.
HOVERGENiHBG050571.
KOiK07532.

Miscellaneous databases

GenomeRNAii23365.
NextBioi45421.

Gene expression databases

BgeeiB4E2K6.
GenevisibleiB4E2K6. HS.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR016137. RGS.
IPR015212. RGS-like_dom.
IPR015721. RhoGEF-like.
[Graphical view]
PANTHERiPTHR22825. PTHR22825. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TracheaImported.

Entry informationi

Entry nameiB4E2K6_HUMAN
AccessioniPrimary (citable) accession number: B4E2K6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 22, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.