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B4E2K6

- B4E2K6_HUMAN

UniProt

B4E2K6 - B4E2K6_HUMAN

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Protein
Submitted name: cDNA FLJ60405, highly similar to Rho guanine nucleotide exchange factor 12
Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ60405, highly similar to Rho guanine nucleotide exchange factor 12Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB4E2K6.

Expressioni

Gene expression databases

ArrayExpressiB4E2K6.
BgeeiB4E2K6.

Structurei

3D structure databases

ProteinModelPortaliB4E2K6.

Family & Domainsi

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation
Contains 1 PH domain.
Contains DH (DBL-homology) domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000034046.
HOVERGENiHBG050571.
KOiK07532.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR016137. Regulat_G_prot_signal_superfam.
IPR015212. RGS-like_dom.
IPR015721. RhoGEF-like.
[Graphical view]
PANTHERiPTHR22825. PTHR22825. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B4E2K6-1 [UniParc]FASTAAdd to Basket

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MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTGLV     50
QRCVIIQKDD NGFGLTVSGD NPVFVQSVKE DGAAMRAGVQ TGDRIIKVNG 100
TLVTHSNHLE VVKLIKSGSY VALTVQGRPP GSPQIPLADS EVEPSVIGHM 150
SPIMTSPHSP GASGNMERIT SPVLMGEENN VVHNQKVEIL RKMLQKEQER 200
LQLLQEDYNR TPAQRLLKEI QEAKKHIPQL QEQLSKATGS AQDGAVVTPS 250
RPLGDTLTVS EAETDPGDVL GRTDCSSGDA SRPSSDNADS PKSGPKERIY 300
LEENPEKSET IQDTDTQSLV GSPSTRIAPH IIGAEDDDFG TEHEQINGQC 350
SCFQSIELLK SRPAHLAVFL HHVVSQFDPA TLLCYLYSDL YKHTNSKETR 400
RIFLEFHQFF LDRSAHLKVS VPDEMSADLE KRRPELIPED LHRHYIQTMQ 450
ERVHPEVQRH LEDFRQKRSM GLTLAESELT KLDAERDKDR LTLEKERTCA 500
EQIVAKIEEV LMTAQAVEED KSSTMQYVIL MYMKHLGVKV KEPRNLEHKR 550
GRIGFLPKIK QSMKKDKEGE EKGKRRGFPS ILGPPRRPSR HDNSAIGRAM 600
ELQKARHPKH LSTPSSVSPE PQDSAKLRQS GLANEGTDAG YLPANSMSSV 650
ASGASFSQEG GKENDTGSKQ VGETSAPGDT LDGTPRTLNT VFDFPPPPLD 700
QVQEEECEVE RVTEHGTPKP FRKFDSVAFG ESQSEDEQFE NDLETDPPNW 750
QQLVSREVLL GLKPCEIKRQ EVINELFYTE RAHVRTLKVL DQVFYQRVSR 800
EGILSPSELR KIFSNLEDIL QLHIGLNEQM KAVRKRNETS VIDQIGEDLL 850
TWFSGPGEEK LKHAAATFCS NQPFALEMIK SRQKKDSRFQ TFVQDAESNP 900
LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK YTEWPTEREK VKKAADHCRQ 950
ILNYVNQAVK EAENKQRLED YQRRLDTSSL KLSEYPNVEE LRNLDLTKRK 1000
MIHEGPLVWK VNRDKTIDLY TLLLEDILVL LQKQDDRLVL RCHSKILAST 1050
ADSKHTFSPV IKLSTVLVRQ VATDNKALFV ISMSDNGAQI YELVAQTVSE 1100
KTVWQDLICR MAASVKEQST KPIPLPQSTP GEGDNDEEDP SKLKEEQHGI 1150
SVTGLQSPDR DLGLESTLIS SKPQSHSLST SGKSEVRDLF VAERQFAKEQ 1200
HTDGTLKEVG EDYQIAIPDS HLPVSEERWA LDALRNLGLL KQLLVQQLGL 1250
TEKSVQEDWQ HFPRYRTASQ GPQTDSVI 1278
Length:1,278
Mass (Da):143,947
Last modified:September 23, 2008 - v1
Checksum:iA6279845201B370A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1278 – 12781Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK304316 mRNA. Translation: BAG65168.1.
RefSeqiNP_001185594.1. NM_001198665.1.
NP_056128.1. NM_015313.2.
UniGeneiHs.24598.

Genome annotation databases

GeneIDi23365.
KEGGihsa:23365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK304316 mRNA. Translation: BAG65168.1 .
RefSeqi NP_001185594.1. NM_001198665.1.
NP_056128.1. NM_015313.2.
UniGenei Hs.24598.

3D structure databases

ProteinModelPortali B4E2K6.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B4E2K6.

Protocols and materials databases

DNASUi 23365.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 23365.
KEGGi hsa:23365.

Organism-specific databases

CTDi 23365.

Phylogenomic databases

HOGENOMi HOG000034046.
HOVERGENi HBG050571.
KOi K07532.

Miscellaneous databases

GenomeRNAii 23365.
NextBioi 45421.

Gene expression databases

ArrayExpressi B4E2K6.
Bgeei B4E2K6.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001478. PDZ.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR016137. Regulat_G_prot_signal_superfam.
IPR015212. RGS-like_dom.
IPR015721. RhoGEF-like.
[Graphical view ]
PANTHERi PTHR22825. PTHR22825. 1 hit.
Pfami PF00595. PDZ. 1 hit.
PF09128. RGS-like. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEi PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TracheaImported.

Entry informationi

Entry nameiB4E2K6_HUMAN
AccessioniPrimary (citable) accession number: B4E2K6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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