B4E2K6 (B4E2K6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ60405, highly similar to Rho guanine nucleotide exchange factor 12 EMBL BAG65168.1
Organism	Homo sapiens (Human) EMBL BAG65168.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1278 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. SAAS SAAS001331 Contains 1 PDZ (DHR) domain. RuleBase RU003354 Contains 1 PH domain.

Ontologies

Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1278	1	EMBL BAG65168.1

Sequences

	Sequence		Length	Mass (Da)
	B4E2K6 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: A6279845201B370A	FASTA	1,278	143,947
	10 20 30 40 50 60 MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTGLV QRCVIIQKDD 70 80 90 100 110 120 NGFGLTVSGD NPVFVQSVKE DGAAMRAGVQ TGDRIIKVNG TLVTHSNHLE VVKLIKSGSY 130 140 150 160 170 180 VALTVQGRPP GSPQIPLADS EVEPSVIGHM SPIMTSPHSP GASGNMERIT SPVLMGEENN 190 200 210 220 230 240 VVHNQKVEIL RKMLQKEQER LQLLQEDYNR TPAQRLLKEI QEAKKHIPQL QEQLSKATGS 250 260 270 280 290 300 AQDGAVVTPS RPLGDTLTVS EAETDPGDVL GRTDCSSGDA SRPSSDNADS PKSGPKERIY 310 320 330 340 350 360 LEENPEKSET IQDTDTQSLV GSPSTRIAPH IIGAEDDDFG TEHEQINGQC SCFQSIELLK 370 380 390 400 410 420 SRPAHLAVFL HHVVSQFDPA TLLCYLYSDL YKHTNSKETR RIFLEFHQFF LDRSAHLKVS 430 440 450 460 470 480 VPDEMSADLE KRRPELIPED LHRHYIQTMQ ERVHPEVQRH LEDFRQKRSM GLTLAESELT 490 500 510 520 530 540 KLDAERDKDR LTLEKERTCA EQIVAKIEEV LMTAQAVEED KSSTMQYVIL MYMKHLGVKV 550 560 570 580 590 600 KEPRNLEHKR GRIGFLPKIK QSMKKDKEGE EKGKRRGFPS ILGPPRRPSR HDNSAIGRAM 610 620 630 640 650 660 ELQKARHPKH LSTPSSVSPE PQDSAKLRQS GLANEGTDAG YLPANSMSSV ASGASFSQEG 670 680 690 700 710 720 GKENDTGSKQ VGETSAPGDT LDGTPRTLNT VFDFPPPPLD QVQEEECEVE RVTEHGTPKP 730 740 750 760 770 780 FRKFDSVAFG ESQSEDEQFE NDLETDPPNW QQLVSREVLL GLKPCEIKRQ EVINELFYTE 790 800 810 820 830 840 RAHVRTLKVL DQVFYQRVSR EGILSPSELR KIFSNLEDIL QLHIGLNEQM KAVRKRNETS 850 860 870 880 890 900 VIDQIGEDLL TWFSGPGEEK LKHAAATFCS NQPFALEMIK SRQKKDSRFQ TFVQDAESNP 910 920 930 940 950 960 LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK YTEWPTEREK VKKAADHCRQ ILNYVNQAVK 970 980 990 1000 1010 1020 EAENKQRLED YQRRLDTSSL KLSEYPNVEE LRNLDLTKRK MIHEGPLVWK VNRDKTIDLY 1030 1040 1050 1060 1070 1080 TLLLEDILVL LQKQDDRLVL RCHSKILAST ADSKHTFSPV IKLSTVLVRQ VATDNKALFV 1090 1100 1110 1120 1130 1140 ISMSDNGAQI YELVAQTVSE KTVWQDLICR MAASVKEQST KPIPLPQSTP GEGDNDEEDP 1150 1160 1170 1180 1190 1200 SKLKEEQHGI SVTGLQSPDR DLGLESTLIS SKPQSHSLST SGKSEVRDLF VAERQFAKEQ 1210 1220 1230 1240 1250 1260 HTDGTLKEVG EDYQIAIPDS HLPVSEERWA LDALRNLGLL KQLLVQQLGL TEKSVQEDWQ 1270 HFPRYRTASQ GPQTDSVI

References

[1]

"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Trachea EMBL BAG65168.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK304316 mRNA. Translation: BAG65168.1.
IPI	IPI00339353.
RefSeq	NP_001185594.1. NM_001198665.1. NP_056128.1. NM_015313.2.
UniGene	Hs.24598.
3D structure databases
ProteinModelPortal	B4E2K6.
ModBase	Search...
Protein-protein interaction databases
STRING	B4E2K6.
Protocols and materials databases
DNASU	23365.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	23365.
KEGG	hsa:23365.
Organism-specific databases
CTD	23365.
Phylogenomic databases
HOGENOM	HOG000034046.
HOVERGEN	HBG050571.
KO	K07532.
Gene expression databases
ArrayExpress	B4E2K6.
Bgee	B4E2K6.
Family and domain databases
Gene3D	1.20.900.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR015212. Regulat_G_prot_signal-like. IPR016137. Regulat_G_prot_signal_superfam. IPR015721. RhoGEF-like. [Graphical view]
PANTHER	PTHR22825. PTHR22825. 1 hit.
Pfam	PF00595. PDZ. 1 hit. PF09128. RGS-like. 1 hit. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit. SSF50156. PDZ. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23365.
NextBio	45421.

Entry information

Entry name

B4E2K6_HUMAN

Accession

Primary (citable) accession number: B4E2K6

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.