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B4E2K6

- B4E2K6_HUMAN

UniProt

B4E2K6 - B4E2K6_HUMAN

Protein
Submitted name:

cDNA FLJ60405, highly similar to Rho guanine nucleotide exchange factor 12

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA FLJ60405, highly similar to Rho guanine nucleotide exchange factor 12Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Proteomic databases

    PRIDEiB4E2K6.

    Expressioni

    Gene expression databases

    ArrayExpressiB4E2K6.
    BgeeiB4E2K6.

    Structurei

    3D structure databases

    ProteinModelPortaliB4E2K6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.UniRule annotation
    Contains 1 PH domain.
    Contains DH (DBL-homology) domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000034046.
    HOVERGENiHBG050571.
    KOiK07532.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR015212. RGS-like_dom.
    IPR015721. RhoGEF-like.
    [Graphical view]
    PANTHERiPTHR22825. PTHR22825. 1 hit.
    PfamiPF00595. PDZ. 1 hit.
    PF09128. RGS-like. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF48097. SSF48097. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEiPS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B4E2K6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTGLV     50
    QRCVIIQKDD NGFGLTVSGD NPVFVQSVKE DGAAMRAGVQ TGDRIIKVNG 100
    TLVTHSNHLE VVKLIKSGSY VALTVQGRPP GSPQIPLADS EVEPSVIGHM 150
    SPIMTSPHSP GASGNMERIT SPVLMGEENN VVHNQKVEIL RKMLQKEQER 200
    LQLLQEDYNR TPAQRLLKEI QEAKKHIPQL QEQLSKATGS AQDGAVVTPS 250
    RPLGDTLTVS EAETDPGDVL GRTDCSSGDA SRPSSDNADS PKSGPKERIY 300
    LEENPEKSET IQDTDTQSLV GSPSTRIAPH IIGAEDDDFG TEHEQINGQC 350
    SCFQSIELLK SRPAHLAVFL HHVVSQFDPA TLLCYLYSDL YKHTNSKETR 400
    RIFLEFHQFF LDRSAHLKVS VPDEMSADLE KRRPELIPED LHRHYIQTMQ 450
    ERVHPEVQRH LEDFRQKRSM GLTLAESELT KLDAERDKDR LTLEKERTCA 500
    EQIVAKIEEV LMTAQAVEED KSSTMQYVIL MYMKHLGVKV KEPRNLEHKR 550
    GRIGFLPKIK QSMKKDKEGE EKGKRRGFPS ILGPPRRPSR HDNSAIGRAM 600
    ELQKARHPKH LSTPSSVSPE PQDSAKLRQS GLANEGTDAG YLPANSMSSV 650
    ASGASFSQEG GKENDTGSKQ VGETSAPGDT LDGTPRTLNT VFDFPPPPLD 700
    QVQEEECEVE RVTEHGTPKP FRKFDSVAFG ESQSEDEQFE NDLETDPPNW 750
    QQLVSREVLL GLKPCEIKRQ EVINELFYTE RAHVRTLKVL DQVFYQRVSR 800
    EGILSPSELR KIFSNLEDIL QLHIGLNEQM KAVRKRNETS VIDQIGEDLL 850
    TWFSGPGEEK LKHAAATFCS NQPFALEMIK SRQKKDSRFQ TFVQDAESNP 900
    LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK YTEWPTEREK VKKAADHCRQ 950
    ILNYVNQAVK EAENKQRLED YQRRLDTSSL KLSEYPNVEE LRNLDLTKRK 1000
    MIHEGPLVWK VNRDKTIDLY TLLLEDILVL LQKQDDRLVL RCHSKILAST 1050
    ADSKHTFSPV IKLSTVLVRQ VATDNKALFV ISMSDNGAQI YELVAQTVSE 1100
    KTVWQDLICR MAASVKEQST KPIPLPQSTP GEGDNDEEDP SKLKEEQHGI 1150
    SVTGLQSPDR DLGLESTLIS SKPQSHSLST SGKSEVRDLF VAERQFAKEQ 1200
    HTDGTLKEVG EDYQIAIPDS HLPVSEERWA LDALRNLGLL KQLLVQQLGL 1250
    TEKSVQEDWQ HFPRYRTASQ GPQTDSVI 1278
    Length:1,278
    Mass (Da):143,947
    Last modified:September 23, 2008 - v1
    Checksum:iA6279845201B370A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1278 – 12781Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK304316 mRNA. Translation: BAG65168.1.
    RefSeqiNP_001185594.1. NM_001198665.1.
    NP_056128.1. NM_015313.2.
    UniGeneiHs.24598.

    Genome annotation databases

    GeneIDi23365.
    KEGGihsa:23365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK304316 mRNA. Translation: BAG65168.1 .
    RefSeqi NP_001185594.1. NM_001198665.1.
    NP_056128.1. NM_015313.2.
    UniGenei Hs.24598.

    3D structure databases

    ProteinModelPortali B4E2K6.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B4E2K6.

    Protocols and materials databases

    DNASUi 23365.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 23365.
    KEGGi hsa:23365.

    Organism-specific databases

    CTDi 23365.

    Phylogenomic databases

    HOGENOMi HOG000034046.
    HOVERGENi HBG050571.
    KOi K07532.

    Miscellaneous databases

    GenomeRNAii 23365.
    NextBioi 45421.

    Gene expression databases

    ArrayExpressi B4E2K6.
    Bgeei B4E2K6.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR015212. RGS-like_dom.
    IPR015721. RhoGEF-like.
    [Graphical view ]
    PANTHERi PTHR22825. PTHR22825. 1 hit.
    Pfami PF00595. PDZ. 1 hit.
    PF09128. RGS-like. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF48097. SSF48097. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEi PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: TracheaImported.

    Entry informationi

    Entry nameiB4E2K6_HUMAN
    AccessioniPrimary (citable) accession number: B4E2K6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.