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B4E220

- B4E220_HUMAN

UniProt

B4E220 - B4E220_HUMAN

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Protein
Submitted name: Aquaporin-1
Gene
AQP1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    TransportUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Aquaporin-1Imported
    Submitted name:
    cDNA FLJ51453, highly similar to Aquaporin-1Imported
    Gene namesi
    Name:AQP1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:633. AQP1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    ProteinModelPortaliB4E220.
    SMRiB4E220. Positions 83-329.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MIP/aquaporin family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000288286.
    HOVERGENiHBG000312.
    PhylomeDBiB4E220.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR023274. Aquaporin_1.
    IPR025257. DUF4205.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view]
    PANTHERiPTHR19139. PTHR19139. 1 hit.
    PfamiPF13898. DUF4205. 1 hit.
    PF00230. MIP. 1 hit.
    [Graphical view]
    PRINTSiPR02013. AQUAPORIN1.
    PR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.
    TIGRFAMsiTIGR00861. MIP. 1 hit.
    PROSITEiPS00221. MIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4E220-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCQVGCFLKT PRFPIWVVCS ESHFSILFSL QPGLLRDWRT ERLFDLYYYD    50
    GLANQQEQIR LTIDTTQTIS EDTDNDLVPP LELCIRTNIG SALGFKYPVG 100
    NNQTAVQDNV KVSLAFGLSI ATLAQSVGHI SGAHLNPAVT LGLLLSCQIS 150
    IFRALMYIIA QCVGAIVATA ILSGITSSLT GNSLGRNDLA DGVNSGQGLG 200
    IEIIGTLQLV LCVLATTDRR RRDLGGSAPL AIGLSVALGH LLAIDYTGCG 250
    INPARSFGSA VITHNFSNHW IFWVGPFIGG ALAVLIYDFI LAPRSSDLTD 300
    RVKVWTSGQV EEYDLDADDI NSRVEMKPK 329
    Length:329
    Mass (Da):35,575
    Last modified:September 23, 2008 - v1
    Checksum:i1969BA704D8D2363
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004691 Genomic DNA. No translation available.
    AC005155 Genomic DNA. No translation available.
    AK304075 mRNA. Translation: BAG64982.1.

    Genome annotation databases

    EnsembliENST00000434909; ENSP00000395059; ENSG00000240583.
    UCSCiuc011kac.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004691 Genomic DNA. No translation available.
    AC005155 Genomic DNA. No translation available.
    AK304075 mRNA. Translation: BAG64982.1 .

    3D structure databases

    ProteinModelPortali B4E220.
    SMRi B4E220. Positions 83-329.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000434909 ; ENSP00000395059 ; ENSG00000240583 .
    UCSCi uc011kac.1. human.

    Organism-specific databases

    HGNCi HGNC:633. AQP1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000288286.
    HOVERGENi HBG000312.
    PhylomeDBi B4E220.

    Miscellaneous databases

    NextBioi 35477178.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR023274. Aquaporin_1.
    IPR025257. DUF4205.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view ]
    PANTHERi PTHR19139. PTHR19139. 1 hit.
    Pfami PF13898. DUF4205. 1 hit.
    PF00230. MIP. 1 hit.
    [Graphical view ]
    PRINTSi PR02013. AQUAPORIN1.
    PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    TIGRFAMsi TIGR00861. MIP. 1 hit.
    PROSITEi PS00221. MIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: TracheaImported.
    3. Ensembl
      Submitted (JAN-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB4E220_HUMAN
    AccessioniPrimary (citable) accession number: B4E220
    Secondary accession number(s): H0Y8K2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: June 11, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

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