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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Submitted name:
cDNA FLJ55673, highly similar to Complement factor B (EC 3.4.21.47)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 12661246Sequence analysisPRO_5007640679Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiB4E1Z4.
PeptideAtlasiB4E1Z4.

Expressioni

Gene expression databases

BgeeiENSG00000243649.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000410815.

Structurei

3D structure databases

SMRiB4E1Z4. Positions 23-155, 176-524, 537-1266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 8665Sushi (CCP/SCR)InterPro annotationAdd
BLAST
Domaini87 – 14458Sushi (CCP/SCR)InterPro annotationAdd
BLAST
Domaini173 – 299127VWFAInterPro annotationAdd
BLAST
Domaini311 – 590280Peptidase S1InterPro annotationAdd
BLAST
Domaini537 – 60266Sushi (CCP/SCR)InterPro annotationAdd
BLAST
Domaini603 – 66260Sushi (CCP/SCR)InterPro annotationAdd
BLAST
Domaini665 – 72258Sushi (CCP/SCR)InterPro annotationAdd
BLAST
Domaini772 – 971200VWFAInterPro annotationAdd
BLAST
Domaini979 – 1259281Peptidase S1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation
Contains 2 peptidase S1 domains.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00530000063826.
HOGENOMiHOG000038034.
HOVERGENiHBG106859.
OMAiNSSDADW.
OrthoDBiEOG091G02G8.
PhylomeDBiB4E1Z4.
TreeFamiTF330194.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.40.50.410. 2 hits.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
PF00089. Trypsin. 2 hits.
PF00092. VWA. 2 hits.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00032. CCP. 5 hits.
SM00020. Tryp_SPc. 2 hits.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 2 hits.
SSF53300. SSF53300. 2 hits.
SSF57535. SSF57535. 5 hits.
PROSITEiPS50923. SUSHI. 5 hits.
PS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E1Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS
60 70 80 90 100
CPQGLYPSPA SRLCKSSGQW QTPGATRSLS KAVCKPGHCP NPGISLGAVR
110 120 130 140 150
TGFRFGHGDK VRYRCSSNLV LTGSSERECQ GNGVWSGTEP ICRQPYSYDF
160 170 180 190 200
PEDVAPALGT SFSHMLGATN PTQKTKDHEN GTGTNTYAAL NSVYLMMNNQ
210 220 230 240 250
MRLLGMETMA WQEIRHAIIL LTDGKSNMGG SPKTAVDHIR EILNINQKRN
260 270 280 290 300
DYLDIYAIGV GKLDVDWREL NELGSKKDGE RHAFILQDTK ALHQVFEHML
310 320 330 340 350
DVSKLTDTIC GVGNMSANAS DQERTPWHVT IKPKSQETCR GALISDQWVL
360 370 380 390 400
TAAHCFRDGN DHSLWRVNVG DPKSQWGKEF LIEKAVISPG FDVFAKKNQG
410 420 430 440 450
ILEFYGDDIA LLKLAQKVKM STHARPICLP CTMEANLALR RPQGSTCRDH
460 470 480 490 500
ENELLNKQSV PAHFVALNGS KLNINLKMGV EWTSCAEVVS QEKTMFPNLT
510 520 530 540 550
DVREVVTDQF LCSGTQEDES PCKGVTTTPW SLARPQGSCS LEGVEIKGGS
560 570 580 590 600
FRLLQEGQAL EYVCPSGFYP YPVQTRTCRS TGSWSTLKTQ DQKTVRKAEC
610 620 630 640 650
RAIHCPRPHD FENGEYWPRS PYYNVSDEIS FHCYDGYTLR GSANRTCQVN
660 670 680 690 700
GRWSGQTAIC DNGAGYCSNP GIPIGTRKVG SQYRLEDSVT YHCSRGLTLR
710 720 730 740 750
GSQRRTCQEG GSWSGTEPSC QDSFMYDTPQ EVAEAFLSSL TETIEGVDAE
760 770 780 790 800
DGHGPGEQQK RKIVLDPSGS MNIYLVLDGS DSIGASNFTG AKKCLVNLIE
810 820 830 840 850
KVASYGVKPR YGLVTYATYP KIWVKVSEAD SSNADWVTKQ LNEINYEDHK
860 870 880 890 900
LKSGTNTKKA LQAVYSMMSW PDDVPPEGWN RTRHVIILMT DGLHNMGGDP
910 920 930 940 950
ITVIDEIRDL LYIGKDRKNP REDYLDVYVF GVGPLVNQVN INALASKKDN
960 970 980 990 1000
EQHVFKVKDM ENLEDVFYQM IDESQSLSLC GMVWEHRKGT DYHKQPWQAK
1010 1020 1030 1040 1050
ISVIRPSKGH ESCMGAVVSE YFVLTAAHCF TVDDKEHSIK VSVGGEKRDL
1060 1070 1080 1090 1100
EIEVVLFHPN YNINGKKEAG IPEFYDYDVA LIKLKNKLKY GQTIRPICLP
1110 1120 1130 1140 1150
CTEGTTRALR LPPTTTCQQQ KEELLPAQDI KALFVSEEEK KLTRKEVYIK
1160 1170 1180 1190 1200
NGDKKGSCER DAQYAPGYDK VKDISEVVTP RFLCTGGVSP YADPNTCRGD
1210 1220 1230 1240 1250
SGGPLIVHKR SRFIQVGVIS WGVVDVCKNQ KRQKQVPAHA RDFHINLFQV
1260
LPWLKEKLQD EDLGFL
Length:1,266
Mass (Da):140,943
Last modified:September 23, 2008 - v1
Checksum:i89105C1F976EB53D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645922 Genomic DNA. No translation available.
AK304045 mRNA. Translation: BAG64956.1.

Genome annotation databases

EnsembliENST00000456570; ENSP00000410815; ENSG00000244255.
UCSCiuc011dor.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645922 Genomic DNA. No translation available.
AK304045 mRNA. Translation: BAG64956.1.

3D structure databases

SMRiB4E1Z4. Positions 23-155, 176-524, 537-1266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000410815.

Proteomic databases

MaxQBiB4E1Z4.
PeptideAtlasiB4E1Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456570; ENSP00000410815; ENSG00000244255.
UCSCiuc011dor.4. human.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00530000063826.
HOGENOMiHOG000038034.
HOVERGENiHBG106859.
OMAiNSSDADW.
OrthoDBiEOG091G02G8.
PhylomeDBiB4E1Z4.
TreeFamiTF330194.

Miscellaneous databases

ChiTaRSiCFB. human.

Gene expression databases

BgeeiENSG00000243649.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.40.50.410. 2 hits.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
PF00089. Trypsin. 2 hits.
PF00092. VWA. 2 hits.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00032. CCP. 5 hits.
SM00020. Tryp_SPc. 2 hits.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 2 hits.
SSF53300. SSF53300. 2 hits.
SSF57535. SSF57535. 5 hits.
PROSITEiPS50923. SUSHI. 5 hits.
PS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4E1Z4_HUMAN
AccessioniPrimary (citable) accession number: B4E1Z4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.