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Protein
Submitted name:

cDNA FLJ55673, highly similar to Complement factor B (EC 3.4.21.47)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ55673, highly similar to Complement factor B (EC 3.4.21.47)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000244255.5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501010544321 – 1266Sequence analysisAdd BLAST1246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi115 ↔ 142PROSITE-ProRule annotation
Disulfide bondi633 ↔ 660PROSITE-ProRule annotation
Disulfide bondi693 ↔ 720PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiB4E1Z4.

Expressioni

Gene expression databases

BgeeiENSG00000244255.
ExpressionAtlasiB4E1Z4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000410815.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 86SushiInterPro annotationAdd BLAST65
Domaini87 – 144SushiInterPro annotationAdd BLAST58
Domaini173 – 299VWFAInterPro annotationAdd BLAST127
Domaini311 – 590Peptidase S1InterPro annotationAdd BLAST280
Domaini537 – 602SushiInterPro annotationAdd BLAST66
Domaini603 – 662SushiInterPro annotationAdd BLAST60
Domaini665 – 722SushiInterPro annotationAdd BLAST58
Domaini772 – 971VWFAInterPro annotationAdd BLAST200
Domaini979 – 1259Peptidase S1InterPro annotationAdd BLAST281

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00530000063826.
HOGENOMiHOG000038034.
HOVERGENiHBG106859.
OMAiLSTTCQQ.
OrthoDBiEOG091G02G8.
TreeFamiTF330194.

Family and domain databases

CDDicd00033. CCP. 4 hits.
cd00190. Tryp_SPc. 1 hit.
Gene3Di3.40.50.410. 2 hits.
InterProiView protein in InterPro
IPR028341. Complement_B.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR035976. Sushi/SCR/CCP_sf.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
IPR002035. VWF_A.
IPR036465. vWFA_dom_sf.
PANTHERiPTHR19325:SF394. PTHR19325:SF394. 4 hits.
PfamiView protein in Pfam
PF00084. Sushi. 4 hits.
PF00089. Trypsin. 2 hits.
PF00092. VWA. 2 hits.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00032. CCP. 5 hits.
SM00020. Tryp_SPc. 2 hits.
SM00327. VWA. 2 hits.
SUPFAMiSSF50494. SSF50494. 2 hits.
SSF53300. SSF53300. 2 hits.
SSF57535. SSF57535. 5 hits.
PROSITEiView protein in PROSITE
PS50923. SUSHI. 5 hits.
PS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.
PS50234. VWFA. 2 hits.

Sequencei

Sequence statusi: Complete.

B4E1Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS
60 70 80 90 100
CPQGLYPSPA SRLCKSSGQW QTPGATRSLS KAVCKPGHCP NPGISLGAVR
110 120 130 140 150
TGFRFGHGDK VRYRCSSNLV LTGSSERECQ GNGVWSGTEP ICRQPYSYDF
160 170 180 190 200
PEDVAPALGT SFSHMLGATN PTQKTKDHEN GTGTNTYAAL NSVYLMMNNQ
210 220 230 240 250
MRLLGMETMA WQEIRHAIIL LTDGKSNMGG SPKTAVDHIR EILNINQKRN
260 270 280 290 300
DYLDIYAIGV GKLDVDWREL NELGSKKDGE RHAFILQDTK ALHQVFEHML
310 320 330 340 350
DVSKLTDTIC GVGNMSANAS DQERTPWHVT IKPKSQETCR GALISDQWVL
360 370 380 390 400
TAAHCFRDGN DHSLWRVNVG DPKSQWGKEF LIEKAVISPG FDVFAKKNQG
410 420 430 440 450
ILEFYGDDIA LLKLAQKVKM STHARPICLP CTMEANLALR RPQGSTCRDH
460 470 480 490 500
ENELLNKQSV PAHFVALNGS KLNINLKMGV EWTSCAEVVS QEKTMFPNLT
510 520 530 540 550
DVREVVTDQF LCSGTQEDES PCKGVTTTPW SLARPQGSCS LEGVEIKGGS
560 570 580 590 600
FRLLQEGQAL EYVCPSGFYP YPVQTRTCRS TGSWSTLKTQ DQKTVRKAEC
610 620 630 640 650
RAIHCPRPHD FENGEYWPRS PYYNVSDEIS FHCYDGYTLR GSANRTCQVN
660 670 680 690 700
GRWSGQTAIC DNGAGYCSNP GIPIGTRKVG SQYRLEDSVT YHCSRGLTLR
710 720 730 740 750
GSQRRTCQEG GSWSGTEPSC QDSFMYDTPQ EVAEAFLSSL TETIEGVDAE
760 770 780 790 800
DGHGPGEQQK RKIVLDPSGS MNIYLVLDGS DSIGASNFTG AKKCLVNLIE
810 820 830 840 850
KVASYGVKPR YGLVTYATYP KIWVKVSEAD SSNADWVTKQ LNEINYEDHK
860 870 880 890 900
LKSGTNTKKA LQAVYSMMSW PDDVPPEGWN RTRHVIILMT DGLHNMGGDP
910 920 930 940 950
ITVIDEIRDL LYIGKDRKNP REDYLDVYVF GVGPLVNQVN INALASKKDN
960 970 980 990 1000
EQHVFKVKDM ENLEDVFYQM IDESQSLSLC GMVWEHRKGT DYHKQPWQAK
1010 1020 1030 1040 1050
ISVIRPSKGH ESCMGAVVSE YFVLTAAHCF TVDDKEHSIK VSVGGEKRDL
1060 1070 1080 1090 1100
EIEVVLFHPN YNINGKKEAG IPEFYDYDVA LIKLKNKLKY GQTIRPICLP
1110 1120 1130 1140 1150
CTEGTTRALR LPPTTTCQQQ KEELLPAQDI KALFVSEEEK KLTRKEVYIK
1160 1170 1180 1190 1200
NGDKKGSCER DAQYAPGYDK VKDISEVVTP RFLCTGGVSP YADPNTCRGD
1210 1220 1230 1240 1250
SGGPLIVHKR SRFIQVGVIS WGVVDVCKNQ KRQKQVPAHA RDFHINLFQV
1260
LPWLKEKLQD EDLGFL
Length:1,266
Mass (Da):140,943
Last modified:September 23, 2008 - v1
Checksum:i89105C1F976EB53D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645922 Genomic DNA. No translation available.
AK304045 mRNA. Translation: BAG64956.1.

Genome annotation databases

EnsembliENST00000456570; ENSP00000410815; ENSG00000244255.
UCSCiuc011dor.4. human.

Similar proteinsi

Entry informationi

Entry nameiB4E1Z4_HUMAN
AccessioniPrimary (citable) accession number: B4E1Z4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 25, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported