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Protein

Syndecan

Gene

SDC4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
SyndecanUniRule annotation
Gene namesi
Name:SDC4Imported
ORF Names:hCG_38363Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei74 – 9825HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Glycoprotein, Heparan sulfateUniRule annotation, Proteoglycan

Proteomic databases

PeptideAtlasiB4E1S6.

Expressioni

Gene expression databases

BgeeiENSG00000124145.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361818.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 115194.1mInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
HOVERGENiHBG004501.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E1S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGPEVVHPL VPLDNHIPER AGSGSQVPTE PKKLEENEVI PKRISPVEES
60 70 80 90 100
EDVSNKVSMS STVQGSNIFE RTEVLAALIV GGIVGILFAV FLILLLMYRM
110 120
KKKDEGSYDL GKKPIYKKAP TNEFYA
Length:126
Mass (Da):13,910
Last modified:September 23, 2008 - v1
Checksum:iFFFFA5D3D4B914A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303964 mRNA. Translation: BAG64888.1.
CH471077 Genomic DNA. Translation: EAW75860.1.
RefSeqiXP_011527279.1. XM_011528977.2.
UniGeneiHs.632267.

Genome annotation databases

GeneIDi6385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303964 mRNA. Translation: BAG64888.1.
CH471077 Genomic DNA. Translation: EAW75860.1.
RefSeqiXP_011527279.1. XM_011528977.2.
UniGeneiHs.632267.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361818.

Proteomic databases

PeptideAtlasiB4E1S6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6385.

Organism-specific databases

CTDi6385.

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
HOVERGENiHBG004501.

Miscellaneous databases

ChiTaRSiSDC4. human.
GenomeRNAii6385.

Gene expression databases

BgeeiENSG00000124145.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4E1S6_HUMAN
AccessioniPrimary (citable) accession number: B4E1S6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.