ID   B4E1M2_HUMAN            Unreviewed;       502 AA.
AC   B4E1M2;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   SubName: Full=cDNA FLJ54951, highly similar to Epoxide hydrolase 2 {ECO:0000313|EMBL:BAG64834.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG64834.1};
RN   [1] {ECO:0000313|EMBL:BAG64834.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Trachea {ECO:0000313|EMBL:BAG64834.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AK303904; BAG64834.1; -; mRNA.
DR   AlphaFoldDB; B4E1M2; -.
DR   ESTHER; human-EPHX2; Epoxide_hydrolase.
DR   MEROPS; S33.973; -.
DR   MaxQB; B4E1M2; -.
DR   PeptideAtlas; B4E1M2; -.
DR   ProteomicsDB; 5769; -.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd02603; HAD_sEH-N_like; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006439; HAD-SF_hydro_IA.
DR   InterPro; IPR011945; HAD-SF_ppase_IA/epoxid_hydro_N.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR023198; PGP-like_dom2.
DR   NCBIfam; TIGR02247; HAD-1A3-hyp; 1.
DR   NCBIfam; TIGR01509; HAD-SF-IA-v3; 1.
DR   PANTHER; PTHR47829:SF2; AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47829; HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED; 1.
DR   Pfam; PF00561; Abhydrolase_1; 2.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00413; HADHALOGNASE.
DR   SFLD; SFLDG01130; C1.5.1:_Epoxide_Hydrolase_Phos; 1.
DR   SFLD; SFLDG01129; C1.5:_HAD__Beta-PGM__Phosphata; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
PE   2: Evidence at transcript level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Hydrolase {ECO:0000313|EMBL:BAG64834.1}.
FT   DOMAIN          263..319
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000259|Pfam:PF00561"
FT   DOMAIN          320..478
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000259|Pfam:PF00561"
SQ   SEQUENCE   502 AA;  56629 MW;  562297B7EF6F5EB1 CRC64;
     MTLRAAVFDL DGVLALPAVF GVLGRTEEAL ALPRGLLNDA FQKGGPEGAT TRLMKGEITL
     SQWIPLMEEN CRKCSETAKV CLPKNFSIKE IFDKAISARK INRPMLQAAL MLRKKAFCSG
     FTTAILTNTW LDDRAERDGL AQLMCELKMH FDFLIESCQV GMVKPEPQIY KFLLDTLKAS
     PSEVVFLDDI GANLKPARDL GMVTILVQDT DTALKELEKV TGIQLLNTPA PLPTSCNPSD
     MSHGYVTVKP RVRLHFVELG SGPAVCLCHG FPESWYSWRY QIPALAQAGY RVLAMDMKGY
     GESSAPPEIE EYCMEVLCKE SIKANPVFDY QLYFQEPGVA EAELEQNLSR TFKSLFRASD
     ESVLSMHKVC EAGGLFVNSP EEPSLSRMVT EEEIQFYVQQ FKKSGFRGPL NWYRNMERNW
     KWACKSLGRK ILIPALMVTA EKDFVLVPQM SQHMEDWIPH LKRGHIEDCG HWTQMDKPTE
     VNQILIKWLD SDARNPPVVS KM
//