ID   B4E1D3_HUMAN            Unreviewed;       474 AA.
AC   B4E1D3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   13-SEP-2023, entry version 82.
DE   SubName: Full=cDNA FLJ53952, highly similar to Fibrinogen beta chain {ECO:0000313|EMBL:BAG64745.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG64745.1};
RN   [1] {ECO:0000313|EMBL:BAG64745.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:BAG64745.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC       identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC       head to head conformation with the N-termini in a small central domain.
CC       {ECO:0000256|ARBA:ARBA00025974}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; AK303788; BAG64745.1; -; mRNA.
DR   AlphaFoldDB; B4E1D3; -.
DR   SMR; B4E1D3; -.
DR   MaxQB; B4E1D3; -.
DR   PeptideAtlas; B4E1D3; -.
DR   ProteomicsDB; 5747; -.
DR   GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0030168; P:platelet activation; IEA:InterPro.
DR   GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 1.20.5.50; -; 2.
DR   Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR   InterPro; IPR037579; Fibrinogen.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   NCBIfam; NF040941; GGGWT_bact; 1.
DR   PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR   PANTHER; PTHR47221:SF2; FIBRINOGEN BETA CHAIN; 1.
DR   Pfam; PF08702; Fib_alpha; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SMART; SM01212; Fib_alpha; 1.
DR   SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR   SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   2: Evidence at transcript level;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..474
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002804037"
FT   DOMAIN          215..471
FT                   /note="Fibrinogen C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51406"
FT   REGION          49..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          178..205
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   474 AA;  54253 MW;  154FA4BE9CD8B475 CRC64;
     MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD KKREEARPAK
     AAATQKKVER KAPDAGGCLH ADPDLGVLCP TGCQLQEALL QQERPIRNSV DELNNNVEAV
     SQTSSSSFQY MYLLKDLWQK RQKQVKDNEN VVNEYSSELE KHQLYIDETV NSNIPTNLRV
     LRSILENLRS KIQKLESDVS AQMEYCRTPC TVSCNIPVVS GKECEEIIRK GGETSEMYLI
     QPDSSVKPYR VYCDMNTENG GWTVIQNRQD GSVDFGRKWD PYKQGFGNVA TNTDGKNYCG
     LPGEYWLGND KISQLTRMGP TELLIEMEDW KGDKVKAHYG GFTVQNEANK YQISVNKYRG
     TAGNALMDGA SQLMGENRTM TIHNGMFFST YDRDNDGWLT SDPRKQCSKE DGGGWWYNRC
     HAANPNGRYY WGGQYTWDMA KHGTDDGVVW MNWKGSWYSM RKMSMKIRPF FPQQ
//