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Protein
Submitted name:

Histidine--tRNA ligase, cytoplasmic

Gene

HARS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseImported, Ligase

Names & Taxonomyi

Protein namesi
Submitted name:
Histidine--tRNA ligase, cytoplasmicImported
Submitted name:
cDNA FLJ58562, highly similar to Histidyl-tRNA synthetase (EC 6.1.1.21)Imported
Gene namesi
Name:HARSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170445.12
HGNCiHGNC:4816 HARS

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170445

Expressioni

Gene expression databases

BgeeiENSG00000170445

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 59WHEP-TRSInterPro annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 41Sequence analysisAdd BLAST21
Coiled coili276 – 303Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1936 Eukaryota
COG0124 LUCA
GeneTreeiENSGT00390000005922
HOGENOMiHOG000018075
HOVERGENiHBG002731

Family and domain databases

CDDicd00859 HisRS_anticodon, 1 hit
Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR004516 HisRS/HisZ
IPR033656 HisRS_anticodon
IPR009068 S15_NS1_RNA-bd
IPR000738 WHEP-TRS_dom
PANTHERiPTHR11476 PTHR11476, 2 hits
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF00458 WHEP-TRS, 1 hit
PIRSFiPIRSF001549 His-tRNA_synth, 1 hit
SMARTiView protein in SMART
SM00991 WHEP-TRS, 1 hit
SUPFAMiSSF47060 SSF47060, 1 hit
PROSITEiView protein in PROSITE
PS00762 WHEP_TRS_1, 1 hit
PS51185 WHEP_TRS_2, 1 hit

Sequencei

Sequence statusi: Complete.

B4E1C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES
60 70 80 90 100
KQKFVLKTPK DFDIAGNFDP MIPDAECLKI MCEILSSLQI GDFLVKVNDR
110 120 130 140 150
RILDGMFAIC GVSDSKFRTI CSSVDKLDKV SWEEVKNEMV GEKGLAPEVA
160 170 180 190 200
DRIGDYVQQH GGVSLVEQLL QDPKLSQNKQ ALEGLGDLKL LFEYLTLFGI
210 220 230 240 250
DDKISFDLSL ARGLDYYTGV IYEAVLLQTP AQAGEEPLGV GSVAAGGRYD
260 270 280 290 300
GLVGMFDPKG RKVPCVGLSI GVERIFSIVE QRLEALEEKI RTTETQVLVA
310 320 330 340 350
SAQKKLLEER LKLVSELWDA GIKAELLYKK NPKLLNQLQY CEEAGIPLVA
360 370 380 390
IIGEQELKDG VIKLRSVTSR EEVDVRREDL VEEIKRRTGQ PLCIC
Length:395
Mass (Da):43,879
Last modified:September 23, 2008 - v1
Checksum:i2A282CBBC98845F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116353 Genomic DNA No translation available.
AK303778 mRNA Translation: BAG64737.1
RefSeqiNP_001276022.1, NM_001289093.1
UniGeneiHs.528050

Genome annotation databases

EnsembliENST00000431330; ENSP00000393244; ENSG00000170445
GeneIDi3035
UCSCiuc011czp.5 human

Similar proteinsi

Entry informationi

Entry nameiB4E1C5_HUMAN
AccessioniPrimary (citable) accession number: B4E1C5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health