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B4E127

- B4E127_HUMAN

UniProt

B4E127 - B4E127_HUMAN

Protein
Submitted name:

G/T mismatch-specific thymine DNA glycosylase

Gene

TDG

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA N-glycosylase activity Source: Ensembl
    2. mismatched DNA binding Source: InterPro
    3. RNA polymerase II transcription cofactor activity Source: Ensembl

    GO - Biological processi

    1. DNA demethylation Source: Ensembl
    2. embryo development Source: Ensembl
    3. mismatch repair Source: InterPro
    4. negative regulation of chromatin binding Source: Ensembl
    5. negative regulation of protein binding Source: Ensembl
    6. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    G/T mismatch-specific thymine DNA glycosylaseImported
    Submitted name:
    cDNA FLJ50939, highly similar to G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.-)Imported
    Gene namesi
    Name:TDGImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:11700. TDG.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA
    2. plasma membrane Source: HPA
    3. PML body Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36419.

    Structurei

    3D structure databases

    SMRiB4E127. Positions 1-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG003685.
    KOiK03649.

    Family and domain databases

    Gene3Di3.40.470.10. 1 hit.
    InterProiIPR015637. DNA_glycosylase_G/T-mismatch.
    IPR003310. Thymine-DNA_glycosylase.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view]
    PANTHERiPTHR12159. PTHR12159. 1 hit.
    PfamiPF03167. UDG. 1 hit.
    [Graphical view]
    SUPFAMiSSF52141. SSF52141. 1 hit.
    TIGRFAMsiTIGR00584. mug. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4E127-1 [UniParc]FASTAAdd to Basket

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    MAAYKGHHYP GPGNHFWKCL FMSGLSEVQL NHMDDHTLPG KYGIGFTNMV    50
    ERTTPGSKDL SSKEFREGGR ILVQKLQKYQ PRIAVFNGKC IYEIFSKEVF 100
    GVKVKNLEFG LQPHKIPDTE TLCYVMPSSS ARCAQFPRAQ DKVHYYIKLK 150
    DLRDQLKGIE RNMDVQEVQY TFDLQLAQED AKKMAVKEEK YDPGYEAAYG 200
    GAYGENPCSS EPCGFSSNGL IESVELRGES AFSGIPNGQW MTQSFTDQIP 250
    SFSNHCGTQE QEEESHA 267
    Length:267
    Mass (Da):30,151
    Last modified:September 23, 2008 - v1
    Checksum:i3AABA331B277FAD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC078819 Genomic DNA. No translation available.
    AK303631 mRNA. Translation: BAG64639.1.
    RefSeqiNP_003202.3. NM_003211.4.
    UniGeneiHs.584809.

    Genome annotation databases

    EnsembliENST00000544861; ENSP00000445899; ENSG00000139372.
    GeneIDi6996.
    KEGGihsa:6996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC078819 Genomic DNA. No translation available.
    AK303631 mRNA. Translation: BAG64639.1 .
    RefSeqi NP_003202.3. NM_003211.4.
    UniGenei Hs.584809.

    3D structure databases

    SMRi B4E127. Positions 1-189.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000544861 ; ENSP00000445899 ; ENSG00000139372 .
    GeneIDi 6996.
    KEGGi hsa:6996.

    Organism-specific databases

    CTDi 6996.
    HGNCi HGNC:11700. TDG.
    PharmGKBi PA36419.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG003685.
    KOi K03649.

    Miscellaneous databases

    GenomeRNAii 6996.
    NextBioi 27327.

    Family and domain databases

    Gene3Di 3.40.470.10. 1 hit.
    InterProi IPR015637. DNA_glycosylase_G/T-mismatch.
    IPR003310. Thymine-DNA_glycosylase.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view ]
    PANTHERi PTHR12159. PTHR12159. 1 hit.
    Pfami PF03167. UDG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52141. SSF52141. 1 hit.
    TIGRFAMsi TIGR00584. mug. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: ThymusImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB4E127_HUMAN
    AccessioniPrimary (citable) accession number: B4E127
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3