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Protein
Submitted name:

G/T mismatch-specific thymine DNA glycosylase

Gene

TDG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
G/T mismatch-specific thymine DNA glycosylaseImported
Submitted name:
cDNA FLJ50939, highly similar to G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.-)Imported
Gene namesi
Name:TDGImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139372.14
HGNCiHGNC:11700 TDG

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139372
PharmGKBiPA36419

PTM / Processingi

Proteomic databases

MaxQBiB4E127
PeptideAtlasiB4E127
PRIDEiB4E127

Expressioni

Gene expression databases

BgeeiENSG00000139372
ExpressionAtlasiB4E127 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiB4E127, 4 interactors

Structurei

3D structure databases

SMRiB4E127
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 137UDGInterPro annotationAdd BLAST133

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili149 – 169Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4120 Eukaryota
COG3663 LUCA
GeneTreeiENSGT00390000000987
HOVERGENiHBG003685
KOiK20813

Family and domain databases

CDDicd10028 UDG_F2_MUG, 1 hit
Gene3Di3.40.470.10, 1 hit
InterProiView protein in InterPro
IPR015637 MUG/TDG
IPR003310 TDG
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR12159 PTHR12159, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00584 mug, 1 hit

Sequencei

Sequence statusi: Complete.

B4E127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYKGHHYP GPGNHFWKCL FMSGLSEVQL NHMDDHTLPG KYGIGFTNMV
60 70 80 90 100
ERTTPGSKDL SSKEFREGGR ILVQKLQKYQ PRIAVFNGKC IYEIFSKEVF
110 120 130 140 150
GVKVKNLEFG LQPHKIPDTE TLCYVMPSSS ARCAQFPRAQ DKVHYYIKLK
160 170 180 190 200
DLRDQLKGIE RNMDVQEVQY TFDLQLAQED AKKMAVKEEK YDPGYEAAYG
210 220 230 240 250
GAYGENPCSS EPCGFSSNGL IESVELRGES AFSGIPNGQW MTQSFTDQIP
260
SFSNHCGTQE QEEESHA
Length:267
Mass (Da):30,151
Last modified:September 23, 2008 - v1
Checksum:i3AABA331B277FAD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078819 Genomic DNA No translation available.
AK303631 mRNA Translation: BAG64639.1
RefSeqiNP_003202.3, NM_003211.4
XP_011537016.1, XM_011538714.1
UniGeneiHs.584809

Genome annotation databases

EnsembliENST00000544861; ENSP00000445899; ENSG00000139372
GeneIDi6996
KEGGihsa:6996
UCSCiuc010swi.3 human

Similar proteinsi

Entry informationi

Entry nameiB4E127_HUMAN
AccessioniPrimary (citable) accession number: B4E127
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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