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Protein
Submitted name:

cDNA FLJ57286, highly similar to RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ57286, highly similar to RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiB4E0X2
PeptideAtlasiB4E0X2
PRIDEiB4E0X2

Structurei

3D structure databases

ProteinModelPortaliB4E0X2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 103Phorbol-ester/DAG-typeInterPro annotationAdd BLAST47
Domaini268 – 528Protein kinaseInterPro annotationAdd BLAST261

Phylogenomic databases

eggNOGiKOG0193 Eukaryota
ENOG410Y4UP LUCA
HOVERGENiHBG001886

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B4E0X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMANSQILLR QATLSVFSCR TSKEQCKKAR LDWNTDAASL IGEELQVDFL
60 70 80 90 100
DHVPLTTHNF ARKTFLKLAF CDICQKFLLN GFRCQTCGYK FHEHCSTKVP
110 120 130 140 150
TMCVDWSNIR QLLLFPNSTI GDSGVPALPS LTMRRMRESV SRMPVSSQHR
160 170 180 190 200
YSTPHAFTFN TSSPSSEGSL SQRQRSTSTP NVHMVSTTLP VDSRMIEDAI
210 220 230 240 250
RSHSESASPS ALSSSPNNLS PTGWSQPKTP VPAQRERAPV SGTQEKNKIR
260 270 280 290 300
PRGQRDSSYY WEIEASEVML STRIGSGSFG TVYKGKWHGD VAVKILKVVD
310 320 330 340 350
PTPEQFQAFR NEVAVLRKTR HVNILLFMGY MTKDNLAIVT QWCEGSSLYK
360 370 380 390 400
HLHVQETKFQ MFQLIDIARQ TAQGMDYLHA KNIIHRDMKS NNIFLHEGLT
410 420 430 440 450
VKIGDFGLAT VKSRWSGSQQ VEQPTGSVLW MAPEVIRMQD NNPFSFQSDV
460 470 480 490 500
YSYGIVLYEL MTGELPYSHI NNRDQIIFMV GRGYASPDLS KLYKNCPKAM
510 520 530 540 550
KRLVADCVKK VKEERPLFPQ ILSSIELLQH SLPKINRSAS EPSLHRAAHT
560
EDINACTLTT SPRLPVF
Length:567
Mass (Da):64,032
Last modified:September 23, 2008 - v1
Checksum:i249C35B298A9F575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303561 mRNA Translation: BAG64584.1
RefSeqiXP_005265415.1, XM_005265358.4
XP_011532277.1, XM_011533975.2
UniGeneiHs.159130

Similar proteinsi

Entry informationi

Entry nameiB4E0X2_HUMAN
AccessioniPrimary (citable) accession number: B4E0X2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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