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Protein
Submitted name:

cDNA FLJ57286, highly similar to RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ57286, highly similar to RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiB4E0X2.

Expressioni

Gene expression databases

BgeeiB4E0X2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000251849.

Structurei

3D structure databases

ProteinModelPortaliB4E0X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 10347Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini268 – 528261Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0193. Eukaryota.
ENOG410Y4UP. LUCA.
HOVERGENiHBG001886.

Family and domain databases

InterProiIPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E0X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMANSQILLR QATLSVFSCR TSKEQCKKAR LDWNTDAASL IGEELQVDFL
60 70 80 90 100
DHVPLTTHNF ARKTFLKLAF CDICQKFLLN GFRCQTCGYK FHEHCSTKVP
110 120 130 140 150
TMCVDWSNIR QLLLFPNSTI GDSGVPALPS LTMRRMRESV SRMPVSSQHR
160 170 180 190 200
YSTPHAFTFN TSSPSSEGSL SQRQRSTSTP NVHMVSTTLP VDSRMIEDAI
210 220 230 240 250
RSHSESASPS ALSSSPNNLS PTGWSQPKTP VPAQRERAPV SGTQEKNKIR
260 270 280 290 300
PRGQRDSSYY WEIEASEVML STRIGSGSFG TVYKGKWHGD VAVKILKVVD
310 320 330 340 350
PTPEQFQAFR NEVAVLRKTR HVNILLFMGY MTKDNLAIVT QWCEGSSLYK
360 370 380 390 400
HLHVQETKFQ MFQLIDIARQ TAQGMDYLHA KNIIHRDMKS NNIFLHEGLT
410 420 430 440 450
VKIGDFGLAT VKSRWSGSQQ VEQPTGSVLW MAPEVIRMQD NNPFSFQSDV
460 470 480 490 500
YSYGIVLYEL MTGELPYSHI NNRDQIIFMV GRGYASPDLS KLYKNCPKAM
510 520 530 540 550
KRLVADCVKK VKEERPLFPQ ILSSIELLQH SLPKINRSAS EPSLHRAAHT
560
EDINACTLTT SPRLPVF
Length:567
Mass (Da):64,032
Last modified:September 23, 2008 - v1
Checksum:i249C35B298A9F575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303561 mRNA. Translation: BAG64584.1.
RefSeqiXP_005265415.1. XM_005265358.3.
XP_011532277.1. XM_011533975.1.
UniGeneiHs.159130.

Genome annotation databases

GeneIDi5894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303561 mRNA. Translation: BAG64584.1.
RefSeqiXP_005265415.1. XM_005265358.3.
XP_011532277.1. XM_011533975.1.
UniGeneiHs.159130.

3D structure databases

ProteinModelPortaliB4E0X2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000251849.

Proteomic databases

PaxDbiB4E0X2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5894.

Organism-specific databases

CTDi5894.

Phylogenomic databases

eggNOGiKOG0193. Eukaryota.
ENOG410Y4UP. LUCA.
HOVERGENiHBG001886.

Miscellaneous databases

ChiTaRSiRAF1. human.
GenomeRNAii5894.

Gene expression databases

BgeeiB4E0X2.

Family and domain databases

InterProiIPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThymusImported.

Entry informationi

Entry nameiB4E0X2_HUMAN
AccessioniPrimary (citable) accession number: B4E0X2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.