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Protein

Integrin beta

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotationImported

Keywords - Biological processi

Cell adhesionUniRule annotation

Enzyme and pathway databases

SignaLinkiB4E0R1.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei632 – 65827HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiB4E0R1.
PRIDEiB4E0R1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 378378INBInterPro annotationAdd
BLAST
Domaini553 – 63179Integrin_B_tailInterPro annotationAdd
BLAST
Domaini655 – 70046Integrin_b_cytInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation
Contains VWFA domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
HOVERGENiHBG006190.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF15. PTHR10082:SF15. 1 hit.
PfamiPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E0R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGCAADDIM DPTSLAETQE DHNGGQKQLS PQKVTLYLRP GQAAAFNVTF
60 70 80 90 100
RRAKGYPIDL YYLMDLSYSM LDDLRNVKKL GGDLLRALNE ITESGRIGFG
110 120 130 140 150
SFVDKTVLPF VNTHPDKLRN PCPNKEKECQ PPFAFRHVLK LTNNSNQFQT
160 170 180 190 200
EVGKQLISGN LDAPEGGLDA MMQVAACPEE IGWRNVTRLL VFATDDGFHF
210 220 230 240 250
AGDGKLGAIL TPNDGRCHLE DNLYKRSNEF DYPSVGQLAH KLAENNIQPI
260 270 280 290 300
FAVTSRMVKT YEKLTEIIPK SAVGELSEDS SNVVHLIKNA YNKLSSRVFL
310 320 330 340 350
DHNALPDTLK VTYDSFCSNG VTHRNQPRGD CDGVQINVPI TFQVKVTATE
360 370 380 390 400
CIQEQSFVIR ALGFTDIVTV QVLPQCECRC RDQSRDRSLC HGKGFLECGI
410 420 430 440 450
CRCDTGYIGK NCECQTQGRS SQELEGSCRK DNNSIICSGL GDCVCGQCLC
460 470 480 490 500
HTSDVPGKLI YGQYCECDTI NCERYNGQVC GGPGRGLCFC GKCRCHPGFE
510 520 530 540 550
GSACQCERTT EGCLNPRRVE CSGRGRCRCN VCECHSGYQL PLCQECPGCP
560 570 580 590 600
SPCGKYISCA ECLKFEKGPF GKNCSAACPG LQLSNNPVKG RTCKERDSEG
610 620 630 640 650
CWVAYTLEQQ DGMDRYLIYV DESRECVAGP NIAAIVGGTV AGIVLIGILL
660 670 680 690 700
LVIWKALIHL SDLREYRRFE KEKLKSQWNN DNPLFKSATT TVMNPKFAES
Length:700
Mass (Da):77,355
Last modified:September 23, 2008 - v1
Checksum:i212FE992C68B6B89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303488 mRNA. Translation: BAG64523.1.
RefSeqiNP_001290167.1. NM_001303238.1.
XP_006724064.1. XM_006724001.1.
UniGeneiHs.375957.

Genome annotation databases

GeneIDi3689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303488 mRNA. Translation: BAG64523.1.
RefSeqiNP_001290167.1. NM_001303238.1.
XP_006724064.1. XM_006724001.1.
UniGeneiHs.375957.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303242.

Proteomic databases

PaxDbiB4E0R1.
PRIDEiB4E0R1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3689.

Organism-specific databases

CTDi3689.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
HOVERGENiHBG006190.

Enzyme and pathway databases

SignaLinkiB4E0R1.

Miscellaneous databases

GenomeRNAii3689.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF15. PTHR10082:SF15. 1 hit.
PfamiPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThymusImported.

Entry informationi

Entry nameiB4E0R1_HUMAN
AccessioniPrimary (citable) accession number: B4E0R1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.