ID   B4E0L1_HUMAN            Unreviewed;       124 AA.
AC   B4E0L1;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=cDNA FLJ52125, highly similar to T-cell-specific surface glycoprotein CD28 {ECO:0000313|EMBL:BAG64473.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG64473.1};
RN   [1] {ECO:0000313|EMBL:BAG64473.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thymus {ECO:0000313|EMBL:BAG64473.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   EMBL; AK303421; BAG64473.1; -; mRNA.
DR   RefSeq; NP_001230006.1; NM_001243077.1.
DR   RefSeq; NP_001230007.1; NM_001243078.1.
DR   AlphaFoldDB; B4E0L1; -.
DR   MaxQB; B4E0L1; -.
DR   PeptideAtlas; B4E0L1; -.
DR   DNASU; 940; -.
DR   GeneID; 940; -.
DR   CTD; 940; -.
DR   OrthoDB; 4108912at2759; -.
DR   BioGRID-ORCS; 940; 21 hits in 1163 CRISPR screens.
DR   GenomeRNAi; 940; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042129; P:regulation of T cell proliferation; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR040216; CTLA4/CD28.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR11494; CYTOTOXIC T-LYMPHOCYTE PROTEIN; 1.
DR   PANTHER; PTHR11494:SF7; T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28; 1.
DR   Genevisible; B4E0L1; HS.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..124
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002803440"
SQ   SEQUENCE   124 AA;  14072 MW;  3A91FF25D56AFB29 CRC64;
     MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD
     SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNHYPCE RETPLSKSPI
     SRTF
//