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Protein
Submitted name:

Valine--tRNA ligase, mitochondrial

Gene

VARS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Valine--tRNA ligase, mitochondrialImported
Submitted name:
cDNA FLJ56191, highly similar to Homo sapiens valyl-tRNA synthetase like (VARSL), mRNAImported
Gene namesi
Name:VARS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21642. VARS2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000206476.
ENSG00000234032.

PTM / Processingi

Proteomic databases

MaxQBiB4E0K6.
PeptideAtlasiB4E0K6.
PRIDEiB4E0K6.

Expressioni

Gene expression databases

BgeeiENSG00000206476.
GenevisibleiB4E0K6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000441000.

Structurei

3D structure databases

ProteinModelPortaliB4E0K6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 729tRNA-synt_1InterPro annotationAdd BLAST617
Domaini779 – 927Anticodon_1InterPro annotationAdd BLAST149

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
COG0525. LUCA.
HOVERGENiHBG017878.
KOiK01873.
PhylomeDBiB4E0K6.

Family and domain databases

CDDicd07962. Anticodon_Ia_Val. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR033705. Anticodon_Ia_Val.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E0K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHLPLASFR PPFWGLRHSR GLPRFHSVST QSEPHGSPIS RRNREAKQKR
60 70 80 90 100
LREKQATLEA EIAGESKSPA ESIKAWRPKE LVLYEIPTKP GEKKDVSGPL
110 120 130 140 150
PPAYSPRYVE AAWYPWWVRE GFFKPEYQAR LPQATGETFS MCIPPPNVTG
160 170 180 190 200
SLHIGHALTV AIQDALVRWH RMRGDQVLWV PGSDHAGIAT QAVVEKQLWK
210 220 230 240 250
ERGVRRHELS REAFLREVWQ WKEAKGGEIC EQLRALGASL DWDRECFTMD
260 270 280 290 300
VGSSVAVTEA FVRLYKAGLL YRNHQLVNWS CALRSAISDI EVENRPLPGH
310 320 330 340 350
TQLRLPGCPT PVSFGLLFSV AFPVDGEPDA EVVVGTTRPE TLPGDVAVAV
360 370 380 390 400
HPDDSRYTHL HGRQLRHPLM GQPLPLITDY AVQPHVGTGA VKVTPAHSPA
410 420 430 440 450
DAEMGARHGL SPLNVIAEDG TMTSLCGDWL QGLHRFVARE KIMSVLSERG
460 470 480 490 500
LFRGLQNHPM VLPICSRSGD VIEYLLKNQW FVRCQEMGAR AAKAVESGAL
510 520 530 540 550
ELSPSFHQKN WQHWFSHIGD WCVSRQLWWG HQIPAYLVVE DHAQGEEDCW
560 570 580 590 600
VVGRSEAEAR EVAAELTGRP GAELTLERDP DVLDTWFSSA LFPFSALGWP
610 620 630 640 650
QETPDLARFY PLSLLETGSD LLLFWVGRMV MLGTQLTGQL PFSKVLLHPM
660 670 680 690 700
VRDRQGRKMS KSLGNVLDPR DIISGVEMQL LQEKLRSGNL DPAELAIVAA
710 720 730 740 750
AQKKDFPHGI PECGTDALRF TLCSHGVQAG DLHLSVSEVQ SCRHFCNKIW
760 770 780 790 800
NALRFILNAL GEKFVPQPAE ELSPSSPMDA WILSRLALAA QECERGFLTR
810 820 830 840 850
ELSLVTHALH HFWLHNLCDV YLEAVKPVLW HSPRPLGPPQ VLFSCADLGL
860 870 880 890 900
RLLAPLMPFL AEELWQRLPP RPGCPPAPSI SVAPYPSACS LEHWRQPELE
910 920 930 940 950
RRFSRVQEVV QVLRALRATY QLTKARPRVL LQSSEPGDQG LFEAFLEPLG
960 970 980 990 1000
TLGYCGAVGL LPPGTAAPSG WAQAPLSDTA QVYMELQGLV DPQIQLPLLA
1010 1020 1030 1040 1050
ARRYKLQKQL DSLTARTPSE GEAGTQRQQK LSSLQLELSK LDKAASHLRQ
1060
LMDEPPAPGS PEL
Length:1,063
Mass (Da):118,504
Last modified:September 23, 2008 - v1
Checksum:i77882E0635509EC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773541 Genomic DNA. No translation available.
CR936875 Genomic DNA. No translation available.
AK303415 mRNA. Translation: BAG64468.1.
RefSeqiNP_001161205.1. NM_001167733.2.
NP_065175.4. NM_020442.5.
UniGeneiHs.597526.

Genome annotation databases

EnsembliENST00000383540; ENSP00000373032; ENSG00000206476.
ENST00000450090; ENSP00000407805; ENSG00000234032.
GeneIDi57176.
KEGGihsa:57176.
UCSCiuc063xka.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773541 Genomic DNA. No translation available.
CR936875 Genomic DNA. No translation available.
AK303415 mRNA. Translation: BAG64468.1.
RefSeqiNP_001161205.1. NM_001167733.2.
NP_065175.4. NM_020442.5.
UniGeneiHs.597526.

3D structure databases

ProteinModelPortaliB4E0K6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000441000.

Proteomic databases

MaxQBiB4E0K6.
PeptideAtlasiB4E0K6.
PRIDEiB4E0K6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383540; ENSP00000373032; ENSG00000206476.
ENST00000450090; ENSP00000407805; ENSG00000234032.
GeneIDi57176.
KEGGihsa:57176.
UCSCiuc063xka.1. human.

Organism-specific databases

CTDi57176.
HGNCiHGNC:21642. VARS2.
OpenTargetsiENSG00000206476.
ENSG00000234032.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
COG0525. LUCA.
HOVERGENiHBG017878.
KOiK01873.
PhylomeDBiB4E0K6.

Miscellaneous databases

GenomeRNAii57176.

Gene expression databases

BgeeiENSG00000206476.
GenevisibleiB4E0K6. HS.

Family and domain databases

CDDicd07962. Anticodon_Ia_Val. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR033705. Anticodon_Ia_Val.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4E0K6_HUMAN
AccessioniPrimary (citable) accession number: B4E0K6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.