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Protein

Mitogen-activated protein kinase

Gene

MAPK14

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:MAPK14Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112062.10.
HGNCiHGNC:6876. MAPK14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112062.

PTM / Processingi

Proteomic databases

MaxQBiB4E0K5.

Expressioni

Gene expression databases

BgeeiENSG00000112062.
ExpressionAtlasiB4E0K5. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 231Protein kinaseInterPro annotationAdd BLAST231

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
PRINTSiPR01773. P38MAPKINASE.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

B4E0K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHENVIGLL DVFTPARSLE EFNDVYLVTH LMGADLNNIV KCQKLTDDHV
60 70 80 90 100
QFLIYQILRG LKYIHSADII HRDLKPSNLA VNEDCELKIL DFGLARHTDD
110 120 130 140 150
EMTGYVATRW YRAPEIMLNW MHYNQTVDIW SVGCIMAELL TGRTLFPGTD
160 170 180 190 200
HIDQLKLILR LVGTPGAELL KKISSESARN YIQSLTQMPK MNFANVFIGA
210 220 230 240 250
NPLAVDLLEK MLVLDSDKRI TAAQALAHAY FAQYHDPDDE PVADPYDQSF
260 270 280
ESRDLLIDEW KSLTYDEVIS FVPPPLDQEE MES
Length:283
Mass (Da):32,357
Last modified:September 23, 2008 - v1
Checksum:iC840DAA6DF8E68B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z95152 Genomic DNA. No translation available.
AK303414 mRNA. Translation: BAG64467.1.
RefSeqiXP_006715061.1. XM_006714998.3.
UniGeneiHs.485233.

Genome annotation databases

EnsembliENST00000468133; ENSP00000419837; ENSG00000112062.
GeneIDi1432.
UCSCiuc011dti.3. human.

Similar proteinsi

Entry informationi

Entry nameiB4E0K5_HUMAN
AccessioniPrimary (citable) accession number: B4E0K5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 22, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported