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Protein

Mitogen-activated protein kinase

Gene

MAPK14

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:MAPK14Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6876. MAPK14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112062.

PTM / Processingi

Proteomic databases

MaxQBiB4E0K5.
PeptideAtlasiB4E0K5.
PRIDEiB4E0K5.

Expressioni

Gene expression databases

BgeeiENSG00000112062.
ExpressionAtlasiB4E0K5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000229794.

Structurei

3D structure databases

ProteinModelPortaliB4E0K5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 231Protein kinaseInterPro annotationAdd BLAST231

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E0K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHENVIGLL DVFTPARSLE EFNDVYLVTH LMGADLNNIV KCQKLTDDHV
60 70 80 90 100
QFLIYQILRG LKYIHSADII HRDLKPSNLA VNEDCELKIL DFGLARHTDD
110 120 130 140 150
EMTGYVATRW YRAPEIMLNW MHYNQTVDIW SVGCIMAELL TGRTLFPGTD
160 170 180 190 200
HIDQLKLILR LVGTPGAELL KKISSESARN YIQSLTQMPK MNFANVFIGA
210 220 230 240 250
NPLAVDLLEK MLVLDSDKRI TAAQALAHAY FAQYHDPDDE PVADPYDQSF
260 270 280
ESRDLLIDEW KSLTYDEVIS FVPPPLDQEE MES
Length:283
Mass (Da):32,357
Last modified:September 23, 2008 - v1
Checksum:iC840DAA6DF8E68B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z95152 Genomic DNA. No translation available.
AK303414 mRNA. Translation: BAG64467.1.
RefSeqiXP_006715061.1. XM_006714998.3.
UniGeneiHs.485233.

Genome annotation databases

EnsembliENST00000468133; ENSP00000419837; ENSG00000112062.
GeneIDi1432.
UCSCiuc011dti.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z95152 Genomic DNA. No translation available.
AK303414 mRNA. Translation: BAG64467.1.
RefSeqiXP_006715061.1. XM_006714998.3.
UniGeneiHs.485233.

3D structure databases

ProteinModelPortaliB4E0K5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000229794.

Proteomic databases

MaxQBiB4E0K5.
PeptideAtlasiB4E0K5.
PRIDEiB4E0K5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000468133; ENSP00000419837; ENSG00000112062.
GeneIDi1432.
UCSCiuc011dti.3. human.

Organism-specific databases

CTDi1432.
HGNCiHGNC:6876. MAPK14.
OpenTargetsiENSG00000112062.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.

Miscellaneous databases

ChiTaRSiMAPK14. human.
GenomeRNAii1432.

Gene expression databases

BgeeiENSG00000112062.
ExpressionAtlasiB4E0K5. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4E0K5_HUMAN
AccessioniPrimary (citable) accession number: B4E0K5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.