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Protein
Submitted name:

TFIIH basal transcription factor complex helicase XPD subunit

Gene

ERCC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHelicaseImported, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
TFIIH basal transcription factor complex helicase XPD subunitImported
Submitted name:
cDNA FLJ57462, highly similar to TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-)Imported
Gene namesi
Name:ERCC2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104884.14.
HGNCiHGNC:3434. ERCC2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104884.

PTM / Processingi

Proteomic databases

MaxQBiB4E0F6.

Expressioni

Gene expression databases

BgeeiENSG00000104884.
ExpressionAtlasiB4E0F6. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 127Helicase ATP-bindingInterPro annotationAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 100Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1131. Eukaryota.
COG1199. LUCA.
GeneTreeiENSGT00550000075092.

Family and domain databases

InterProiView protein in InterPro
IPR010614. DEAD_2.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF06733. DEAD_2. 1 hit.
SMARTiView protein in SMART
SM00488. DEXDc2. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51193. HELICASE_ATP_BIND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B4E0F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNVDGLLV YFPYDYIYPE QFSYMRELKR TLDAKGHGVL EMPSGTGKTV
60 70 80 90 100
SLLALIMAYQ RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LNFYEKQEGE
110 120
KLPFLGLALS SRKNLCIHPE TTSASTP
Length:127
Mass (Da):14,552
Last modified:September 23, 2008 - v1
Checksum:i94AAB6B821664908
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47234 Genomic DNA. No translation available.
AK303358 mRNA. Translation: BAG64418.1.
UniGeneiHs.487294.

Genome annotation databases

EnsembliENST00000591309; ENSP00000465207; ENSG00000104884.
UCSCiuc060zxq.1. human.

Similar proteinsi

Entry informationi

Entry nameiB4E0F6_HUMAN
AccessioniPrimary (citable) accession number: B4E0F6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 27, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported