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Protein
Submitted name:

TFIIH basal transcription factor complex helicase XPD subunit

Gene

ERCC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HelicaseImported, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
TFIIH basal transcription factor complex helicase XPD subunitImported
Submitted name:
cDNA FLJ57462, highly similar to TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-)Imported
Gene namesi
Name:ERCC2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3434. ERCC2.

PTM / Processingi

Proteomic databases

PeptideAtlasiB4E0F6.

Expressioni

Gene expression databases

BgeeiENSG00000104884.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375809.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 127121Helicase ATP-bindingInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili77 – 10024Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1131. Eukaryota.
COG1199. LUCA.
GeneTreeiENSGT00550000075092.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR010614. DEAD_2.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4E0F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNVDGLLV YFPYDYIYPE QFSYMRELKR TLDAKGHGVL EMPSGTGKTV
60 70 80 90 100
SLLALIMAYQ RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LNFYEKQEGE
110 120
KLPFLGLALS SRKNLCIHPE TTSASTP
Length:127
Mass (Da):14,552
Last modified:September 23, 2008 - v1
Checksum:i94AAB6B821664908
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47234 Genomic DNA. No translation available.
AK303358 mRNA. Translation: BAG64418.1.
UniGeneiHs.487294.

Genome annotation databases

EnsembliENST00000591309; ENSP00000465207; ENSG00000104884.
UCSCiuc060zxq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47234 Genomic DNA. No translation available.
AK303358 mRNA. Translation: BAG64418.1.
UniGeneiHs.487294.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000375809.

Proteomic databases

PeptideAtlasiB4E0F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000591309; ENSP00000465207; ENSG00000104884.
UCSCiuc060zxq.1. human.

Organism-specific databases

HGNCiHGNC:3434. ERCC2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1131. Eukaryota.
COG1199. LUCA.
GeneTreeiENSGT00550000075092.

Miscellaneous databases

ChiTaRSiERCC2. human.

Gene expression databases

BgeeiENSG00000104884.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR010614. DEAD_2.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4E0F6_HUMAN
AccessioniPrimary (citable) accession number: B4E0F6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.