B4E0A2 (B4E0A2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ55439, highly similar to TNF receptor-associated factor 5 EMBL BAG64364.1
Organism	Homo sapiens (Human) EMBL BAG64364.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 MATH domain. RuleBase RU004402 Contains 1 RING-type zinc finger. SAAS SAAS008974

Ontologies

Keywords
Domain	Zinc-finger SAAS SAAS008974 RuleBase RU000353
Ligand	Metal-binding Zinc
Molecular function	Receptor EMBL BAG64364.1
Gene Ontology (GO)
Biological_process	positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: InterPro positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4E0A2 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 6FDF94A0E03DA62A	FASTA	568	65,638
	10 20 30 40 50 60 MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC 70 80 90 100 110 120 GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV 130 140 150 160 170 180 ILGRYQQVPL ACCYLLQDHL QQCLFQPVQC SNEKCREPVL RKDLKEHLSA SCQFRKEKCL 190 200 210 220 230 240 YCKKDVVVIN LQNHEENLCP EYPVFCPNNC AKIILKTEVD EHLAVCPEAE QDCPFKHYGC 250 260 270 280 290 300 AVTDKRRNLQ QHEHSALREH MRLVLEKNVQ LEEQISDLHK SLEQKESKIQ QLAETIKKLE 310 320 330 340 350 360 KEFKQFAQLF GKNGSFLPNI QVFASHIDKS AWLEAQVHQL LQMVNQQQNK FDLRPLMEAV 370 380 390 400 410 420 DTVKQKITLL ENNDQRLAVL EEETNKHDTH INIHKAQLSK NEERFKLLEG TCYNGKLIWK 430 440 450 460 470 480 VTDYKMKKRE AVDGHTVSIF SQSFYTSRCG YRLCARAYLN GDGSGRGSHL SLYFVVMRGE 490 500 510 520 530 540 FDSLLQWPFR QRVTLMLLDQ SGKKNIMETF KPDPNSSSFK RPDGEMNIAS GCPRFVAHSV 550 560 LENAKNAYIK DDTLFLKVAV DLTDLEDL

References

[1]

"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Thymus EMBL BAG64364.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK303286 mRNA. Translation: BAG64364.1.
IPI	IPI00005760.
UniGene	Hs.523930.
3D structure databases
ProteinModelPortal	B4E0A2.
SMR	B4E0A2. Positions 29-258, 375-567.
ModBase	Search...
Proteomic databases
PRIDE	B4E0A2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc010psx.2. human.
Phylogenomic databases
HOGENOM	HOG000231557.
HOVERGEN	HBG058222.
Enzyme and pathway databases
SignaLink	B4E0A2.
Gene expression databases
ArrayExpress	B4E0A2.
Bgee	B4E0A2.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR002083. MATH. IPR012227. TNF_rcpt--assoc_TRAF. IPR008974. TRAF-like. IPR027130. TRAF5. IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. IPR001293. Znf_TRAF. [Graphical view]
PANTHER	PTHR10131:SF23. PTHR10131:SF23. 1 hit.
Pfam	PF00917. MATH. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view]
PIRSF	PIRSF015614. TRAF. 1 hit.
SMART	SM00061. MATH. 1 hit. SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF49599. Traf_like. 3 hits.
PROSITE	PS50144. MATH. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. PS50145. ZF_TRAF. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35476692.

Entry information

Entry name

B4E0A2_HUMAN

Accession

Primary (citable) accession number: B4E0A2

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	May 29, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.