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Protein
Submitted name:

cDNA FLJ53577, highly similar to pre-mRNA-splicing factor ATP-dependentRNA helicase DHX16 (EC 3.6.1.-)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotationImported, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ53577, highly similar to pre-mRNA-splicing factor ATP-dependentRNA helicase DHX16 (EC 3.6.1.-)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27205.

PTM / Processingi

Proteomic databases

PRIDEiB4DZ28.

Family & Domainsi

Sequence similaritiesi

Contains helicase ATP-binding domain.SAAS annotation
Contains helicase C-terminal domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG039428.
KOiK12813.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DZ28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEDPRGPKV PRKAVVEKPA RAAEREARAL LEKNRSYRLL EDSEESSEET
60 70 80 90 100
VSRAGSSLQK KRKKRKHLRK KREEEEEEEA SEKGKKKTGG SKQQTEKPES
110 120 130 140 150
EDEWERTERE RLQDLEERDA FAERVRQRDK DRTRNVLERS DKKAYEEAQK
160 170 180 190 200
RLKMAEEDRK AMVPELRKKS RREYLAKRER EKLEDLEAEL ADEEFLFGDV
210 220 230 240 250
ELSRHERQEL KYKRQVRDLA REYRAAGEQE KLEATNRYHM PKETRGQPAR
260 270 280 290 300
AVDLVEEESG APGEEQRRWE EARLGAASLK FGARDAASQE PKYQLVLEEE
310 320 330 340 350
ETIEFVRATQ LQGDEEPSAP PTSTQAQQKE SIQAVRRSLP VFPFREELLA
360 370 380 390 400
AIANHQVLII EGETGSGKTT QIPQYLFEEG YTNKGMKIAC TQPRRVAAMS
410 420 430 440 450
VAARVAREMG VKLGNEVGYS IRFEDCTSER TVLRYMTDGM LLREFLSEPD
460 470 480 490 500
LASYSVVMVD EAHERTLHTD ILFGLIKDVA RFRPELKVLV ASATMDTARF
510 520 530 540 550
STFFDDAPVF RIPGRRFPVD IFYTKAPEAD YLEACVVSVL QIHVTQPPGD
560 570 580 590 600
ILVFLTGQEE IEAACEMLQD RCRRLGSKIR ELLVLPIYAN LPSDMQARIF
610 620 630 640 650
QPTPPGARKV VVATNIAETS LTIEGIIYVL DPGFCKQKSY NPRTGMESLT
660 670 680 690 700
VTPCSKASAN QRAGRAGRAA AGKCFRLYTA WAYQHELEET TVPEIQRTSL
710 720 730 740 750
GNVVLLLKSL GIHDLMHFDF LDPPPYETLL LALEQLYALG ALNHLGELTT
760 770 780 790 800
SGRKMAELLV DPMLSKMILA SEKYSCSEEI LTVAAMLSVN NSIFYRPKDK
810 820 830 840 850
VVHADNARVN FFLPGGDHLV LLNVYTQWAE SGYSSQWCYE NFVQFRSMRR
860 870 880 890 900
ARDVREQLEG LLERVEVGLS PCQGDYIRVR KAITAGYFYH TARLTRSGYR
910 920 930 940 950
TVKQQQTVFI HPNSSLFEQQ PRWLLYHELV LTTKEFMRQV LEIESSWLLE
960 970 980
VTPHYYKAKE LEDPHAKKMP KKIGKTREEL G
Length:981
Mass (Da):112,455
Last modified:September 23, 2008 - v1
Checksum:iB7D496117C4DA182
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302721 mRNA. Translation: BAG63940.1.
RefSeqiNP_001157711.1. NM_001164239.1.
UniGeneiHs.485060.

Genome annotation databases

GeneIDi8449.
KEGGihsa:8449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302721 mRNA. Translation: BAG63940.1.
RefSeqiNP_001157711.1. NM_001164239.1.
UniGeneiHs.485060.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB4DZ28.

Protocols and materials databases

DNASUi8449.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8449.
KEGGihsa:8449.

Organism-specific databases

CTDi8449.
PharmGKBiPA27205.

Phylogenomic databases

HOVERGENiHBG039428.
KOiK12813.

Miscellaneous databases

GenomeRNAii8449.
NextBioi31614.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.

Entry informationi

Entry nameiB4DZ28_HUMAN
AccessioniPrimary (citable) accession number: B4DZ28
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: February 4, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.