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Protein

Diacylglycerol kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiB4DYW1.
PeptideAtlasiB4DYW1.
PRIDEiB4DYW1.

Expressioni

Gene expression databases

GenevisibleiB4DYW1. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000337572.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 218DAGKcInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation
Contains 1 DAGKc domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1170. Eukaryota.
ENOG410XSJR. LUCA.
HOVERGENiHBG051346.

Family and domain databases

InterProiIPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DYW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNISQGCTT GTPAPTPDPP SVTCAERVFL ESPPMACPAK VHTACKDLYH
60 70 80 90 100
PICPLGQCKV SIIPPIALNS TDSDGFCRAT FSFCVSPLLV FVSSKSGDNQ
110 120 130 140 150
GVKFLRRFKQ LLNPAQVFDL MNGGPHLGLR LFQKFDNFRI LVCGGDGSVG
160 170 180 190 200
WVLSEIDKLN LNKQCQLGVL PLGTGNDLAR VLGWGGSYDD DTQLPQILEK
210 220 230 240 250
LERASTKMLD RWSIMTYELK LPPKASLLPG PPEASEEFYM TIYEDSVATH
260 270 280 290 300
LTKILNSDEH AVVISSAKTL CETVKDFVAK VEKTYDKTLE NAVVADAVAS
310 320 330 340 350
KCSVLNEKLE QLLQALHTDS QAAPVLPGLS PLIVEEDAVE SSSEESLGES
360 370 380 390 400
KEQLGDDVTK PSSQKAVKPR EIMLRANSLK KAVRQVIEEA GKVMDDPTVH
410 420 430 440 450
PCEPANQSSD YDSTETDESK EEAKDDGAKE SITVKTAPRS PDARASYGHS
460 470 480 490 500
QTDSVPGPAV AASKENLPVL NTRIICPGLR AGLAASIAGS SIINKMLLAN
510 520 530 540 550
IDPFGATPFI DPDLDSVDGY SEKCVMNNYF GIGLDAKISL EFNNKREEHP
560 570 580 590 600
EKCRSRTKNL MWYGVLGTRE LLQRSYKNLE QRVQLECDGQ YIPLPSLQGI
610 620 630 640 650
AVLNIPSYAG GTNFWGGTKE DDIFAAPSFD DKILEVVAIF DSMQMAVSRV
660 670 680 690 700
IKLQHHRIAQ CRTVKITIFG DEGVPVQVDG EAWVQPPGII KIVHKNRAQM
710 720 730 740 750
LTRDRAFEST LKSWEDKQKC DSGKPVLRTH LYIHHAIDLA TEEVSQMQLC
760 770 780 790 800
SQAAEELITR ICDAATIHCL LEQELAHAVN ACSHALNKAN PRCPESLTRD
810 820 830 840 850
TATEIAINVK ALYNETESLL VGRVPLQLES PHEERVSNAL HSVEVELRKL
860 870 880 890 900
TEIPWLYYIL HPNEDEEPPM DCTKRNNRST VFRIVPKFKK EKVQKQKTSS
910
QPGSGDTESG SCEANSPGN
Length:919
Mass (Da):101,033
Last modified:September 23, 2008 - v1
Checksum:i6D0A68BEF96E7134
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302631 mRNA. Translation: BAG63873.1.
RefSeqiNP_001284358.1. NM_001297429.1.
NP_690874.2. NM_152910.5.
UniGeneiHs.630380.
Hs.659437.
Hs.733239.

Genome annotation databases

GeneIDi160851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302631 mRNA. Translation: BAG63873.1.
RefSeqiNP_001284358.1. NM_001297429.1.
NP_690874.2. NM_152910.5.
UniGeneiHs.630380.
Hs.659437.
Hs.733239.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000337572.

Proteomic databases

PaxDbiB4DYW1.
PeptideAtlasiB4DYW1.
PRIDEiB4DYW1.

Protocols and materials databases

DNASUi160851.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi160851.

Organism-specific databases

CTDi160851.

Phylogenomic databases

eggNOGiKOG1170. Eukaryota.
ENOG410XSJR. LUCA.
HOVERGENiHBG051346.

Miscellaneous databases

GenomeRNAii160851.

Gene expression databases

GenevisibleiB4DYW1. HS.

Family and domain databases

InterProiIPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DYW1_HUMAN
AccessioniPrimary (citable) accession number: B4DYW1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 6, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.