ID   B4DYQ0_HUMAN            Unreviewed;       797 AA.
AC   B4DYQ0;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=cDNA FLJ56177, highly similar to Bile salt export pump {ECO:0000313|EMBL:BAG63812.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG63812.1};
RN   [1] {ECO:0000313|EMBL:BAG63812.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:BAG63812.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC       Multidrug resistance exporter (TC 3.A.1.201) subfamily.
CC       {ECO:0000256|ARBA:ARBA00007577}.
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DR   EMBL; AK302540; BAG63812.1; -; mRNA.
DR   AlphaFoldDB; B4DYQ0; -.
DR   PeptideAtlas; B4DYQ0; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR   CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 1.
DR   Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR43394:SF11; ALPHA-FACTOR-TRANSPORTING ATPASE; 1.
DR   PANTHER; PTHR43394; ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        228..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        273..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        454..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        492..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          232..519
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50929"
FT   DOMAIN          554..792
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
SQ   SEQUENCE   797 AA;  87776 MW;  3E5B28B22F8B4375 CRC64;
     MEDIVQAAKE ANAYNFIMDL PQQFDTLVGE GGGQMSGGQK QRVAIARALI RNPKILLLDM
     ATSALDNESE AMVQEVLSKI QHGHTIISVA HRLSTVRAAD TIIGFEHGTA VERGTHEELL
     ERKGVYFTLV TLQSQGNQAL NEEDIKDATE DDMLARTFSR GSYQDSLRAS IRQRSKSQLS
     YLVHEPPLAV VDHKSTYEED RKDKDIPVQE EVEPAPVRRI LKFSAPEWPY MLVGSVGAAV
     NGTVTPLYAF LFSQILGTFS IPDKEEQRSQ INGVCLLFVA MGCVSLFTQF LQGYAFAKSG
     ELLTKRLRKF GFRAMLGQDI AWFDDLRNSP GALTTRLATD ASQVQGAAGS QIGMIVNSFT
     NVTVAMIIAF SFSWKLSLVI LCFFPFLALS GATQTRMLTG FASRDKQALE MVGQITNEAL
     SNIRTVAGIG KERRFIEALE TELEKPFKTA IQKANIYGFC FAFAQCIMFI ANSASYRYGG
     YLISNEGLHF SYVFRVISAV VLSATALGRA FSYTPSYAKA KISAARFFQL LDRQPPISVY
     NTAGEKWDNF QGKIDFVDCK FTYPSRPDSQ VLNGLSVSIS PGQTLAFVGS SGCGKSTSIQ
     LLERFYDPDQ GKVMIDGHDS KKVNVQFLRS NIGIVSQEPV LFACSIMDNI KYGDNTKEIP
     MERVIAAAKQ AQLHDFVMSL PEKYETNVGS QGSQLSRGEK QRIAIARAIV RDPKILLLDE
     ATSALDTESE KTVQVALDKA REGRTCIVIA HRLSTIQNAD IIAVMAQGVV IEKGTHEELM
     AQKGAYYKLV TTGSPIS
//