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Protein

Receptor protein serine/threonine kinase

Gene

TGFBR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:TGFBR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106799.12
HGNCiHGNC:11772 TGFBR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 78HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106799

Expressioni

Gene expression databases

BgeeiENSG00000106799

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 135GSInterPro annotationAdd BLAST30
Domaini136 – 426Protein kinaseInterPro annotationAdd BLAST291

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOVERGENiHBG054502

Family and domain databases

InterProiView protein in InterPro
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

B4DY26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCIAEIDLIP RDRPFVCAPS SKTGSVTTTY CCNQDHCNKI ELPTTVKSSP
60 70 80 90 100
GLGPVELAAV IAGPVCFVCI SLMLMVYICH NRTVIHHRVP NEEDPSLDRP
110 120 130 140 150
FISEGTTLKD LIYDMTTSGS GSGLPLLVQR TIARTIVLQE SIGKGRFGEV
160 170 180 190 200
WRGKWRGEEV AVKIFSSREE RSWFREAEIY QTVMLRHENI LGFIAADNKD
210 220 230 240 250
NGTWTQLWLV SDYHEHGSLF DYLNRYTVTV EGMIKLALST ASGLAHLHME
260 270 280 290 300
IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI ADLGLAVRHD SATDTIDIAP
310 320 330 340 350
NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW EIARRCSIGG
360 370 380 390 400
IHEDYQLPYY DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK
410 420 430
IMRECWYANG AARLTALRIK KTLSQLSQQE GIKM
Length:434
Mass (Da):48,875
Last modified:September 23, 2008 - v1
Checksum:i238B50CE9BDA2BB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162427 Genomic DNA No translation available.
AK302234 mRNA Translation: BAG63588.1
RefSeqiXP_011517251.1, XM_011518949.2
UniGeneiHs.494622

Genome annotation databases

EnsembliENST00000550253; ENSP00000450052; ENSG00000106799
GeneIDi7046
UCSCiuc011lvc.3 human

Similar proteinsi

Entry informationi

Entry nameiB4DY26_HUMAN
AccessioniPrimary (citable) accession number: B4DY26
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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