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Protein

Receptor protein serine/threonine kinase

Gene

TGFBR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:TGFBR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11772. TGFBR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7822HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiB4DY26.

Expressioni

Gene expression databases

BgeeiENSG00000106799.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364133.

Structurei

3D structure databases

SMRiB4DY26. Positions 1-46, 106-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 13530GSInterPro annotationAdd
BLAST
Domaini136 – 426291Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOVERGENiHBG054502.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DY26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCIAEIDLIP RDRPFVCAPS SKTGSVTTTY CCNQDHCNKI ELPTTVKSSP
60 70 80 90 100
GLGPVELAAV IAGPVCFVCI SLMLMVYICH NRTVIHHRVP NEEDPSLDRP
110 120 130 140 150
FISEGTTLKD LIYDMTTSGS GSGLPLLVQR TIARTIVLQE SIGKGRFGEV
160 170 180 190 200
WRGKWRGEEV AVKIFSSREE RSWFREAEIY QTVMLRHENI LGFIAADNKD
210 220 230 240 250
NGTWTQLWLV SDYHEHGSLF DYLNRYTVTV EGMIKLALST ASGLAHLHME
260 270 280 290 300
IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI ADLGLAVRHD SATDTIDIAP
310 320 330 340 350
NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW EIARRCSIGG
360 370 380 390 400
IHEDYQLPYY DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK
410 420 430
IMRECWYANG AARLTALRIK KTLSQLSQQE GIKM
Length:434
Mass (Da):48,875
Last modified:September 23, 2008 - v1
Checksum:i238B50CE9BDA2BB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162427 Genomic DNA. No translation available.
AK302234 mRNA. Translation: BAG63588.1.
RefSeqiXP_011517251.1. XM_011518949.2.
UniGeneiHs.494622.

Genome annotation databases

EnsembliENST00000550253; ENSP00000450052; ENSG00000106799.
GeneIDi7046.
UCSCiuc011lvc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162427 Genomic DNA. No translation available.
AK302234 mRNA. Translation: BAG63588.1.
RefSeqiXP_011517251.1. XM_011518949.2.
UniGeneiHs.494622.

3D structure databases

SMRiB4DY26. Positions 1-46, 106-431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364133.

Proteomic databases

PeptideAtlasiB4DY26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550253; ENSP00000450052; ENSG00000106799.
GeneIDi7046.
UCSCiuc011lvc.3. human.

Organism-specific databases

CTDi7046.
HGNCiHGNC:11772. TGFBR1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOVERGENiHBG054502.

Miscellaneous databases

ChiTaRSiTGFBR1. human.
GenomeRNAii7046.

Gene expression databases

BgeeiENSG00000106799.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4DY26_HUMAN
AccessioniPrimary (citable) accession number: B4DY26
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.