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B4DXW1

- B4DXW1_HUMAN

UniProt

B4DXW1 - B4DXW1_HUMAN

Protein
Submitted name:

Actin-related protein 3

Gene

ACTR3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. asymmetric cell division Source: Ensembl
    2. establishment or maintenance of cell polarity Source: Ensembl
    3. meiotic cytokinesis Source: Ensembl
    4. positive regulation of actin filament polymerization Source: Ensembl
    5. positive regulation of dendrite morphogenesis Source: Ensembl
    6. positive regulation of filopodium assembly Source: Ensembl
    7. positive regulation of lamellipodium assembly Source: Ensembl
    8. positive regulation of neuron differentiation Source: Ensembl
    9. regulation of myosin II filament organization Source: Ensembl
    10. response to antibiotic Source: Ensembl
    11. response to carbohydrate Source: Ensembl
    12. spindle localization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Actin-related protein 3Imported
    Submitted name:
    cDNA FLJ51148, highly similar to Actin-like protein 3Imported
    Submitted name:
    cDNA FLJ52434, highly similar to Actin-like protein 3Imported
    Submitted name:
    cDNA, FLJ79112, highly similar to Actin-like protein 3Imported
    Submitted name:
    cDNA, FLJ79295, highly similar to Actin-like protein 3Imported
    Gene namesi
    Name:ACTR3Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:170. ACTR3.

    Subcellular locationi

    GO - Cellular componenti

    1. excitatory synapse Source: Ensembl
    2. Golgi membrane Source: Ensembl
    3. hemidesmosome Source: Ensembl
    4. lamellipodium Source: Ensembl
    5. podosome Source: Ensembl

    Structurei

    3D structure databases

    ProteinModelPortaliB4DXW1.
    SMRiB4DXW1. Positions 1-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG003771.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]
    PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4DXW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGVDDLDFF IGDEAIEKPT YATKWPIRHG IVEDWDLMER FMEQVIFKYL    50
    RAEPEDHYFL LTEPPLNTPE NREYTAEIMF ESFNVPGLYI AVQAVLALAA 100
    SWTSRQVGER TLTGTVIDSG DGVTHVIPVA EGYVIGSCIK HIPIAGRDIT 150
    YFIQQLLRDR EVGIPPEQSL ETAKAVKERY SYVCPDLVKE FNKYDTDGSK 200
    WIKQYTGINA ISKKEFSIDV GYERFLGPEI FFHPEFANPD FTQPISEVVD 250
    EVIQNCPIDV RRPLYKNIVL SGGSTMFRDF GRRLQRDLKR TVDARLKLSE 300
    ELSGGRLKPK PIDVQVITHH MQRYAVWFGG SMLASTPEFY QVCHTKKDYE 350
    EIGPSICRHN PVFGVMS 367
    Length:367
    Mass (Da):42,004
    Last modified:September 23, 2008 - v1
    Checksum:iD757C18AD8C4174B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC110769 Genomic DNA. No translation available.
    AK302152 mRNA. Translation: BAG63523.1.
    AK302359 mRNA. Translation: BAG63684.1.
    AK316213 mRNA. Translation: BAH14584.1.
    AK316396 mRNA. Translation: BAH14767.1.
    RefSeqiNP_001264069.1. NM_001277140.1.
    UniGeneiHs.433512.
    Hs.595349.

    Genome annotation databases

    EnsembliENST00000535589; ENSP00000444987; ENSG00000115091.
    GeneIDi10096.
    KEGGihsa:10096.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC110769 Genomic DNA. No translation available.
    AK302152 mRNA. Translation: BAG63523.1 .
    AK302359 mRNA. Translation: BAG63684.1 .
    AK316213 mRNA. Translation: BAH14584.1 .
    AK316396 mRNA. Translation: BAH14767.1 .
    RefSeqi NP_001264069.1. NM_001277140.1.
    UniGenei Hs.433512.
    Hs.595349.

    3D structure databases

    ProteinModelPortali B4DXW1.
    SMRi B4DXW1. Positions 1-366.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000535589 ; ENSP00000444987 ; ENSG00000115091 .
    GeneIDi 10096.
    KEGGi hsa:10096.

    Organism-specific databases

    CTDi 10096.
    HGNCi HGNC:170. ACTR3.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG003771.

    Miscellaneous databases

    ChiTaRSi ACTR3. human.
    GenomeRNAii 10096.
    NextBioi 35476075.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    PROSITEi PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: TestisImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: TestisImported.
    5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB4DXW1_HUMAN
    AccessioniPrimary (citable) accession number: B4DXW1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3