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B4DXW1

- B4DXW1_HUMAN

UniProt

B4DXW1 - B4DXW1_HUMAN

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Protein
Submitted name:

Actin-related protein 3

Gene

ACTR3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. asymmetric cell division Source: Ensembl
  2. establishment or maintenance of cell polarity Source: Ensembl
  3. meiotic chromosome movement towards spindle pole Source: Ensembl
  4. meiotic cytokinesis Source: Ensembl
  5. positive regulation of actin filament polymerization Source: Ensembl
  6. positive regulation of dendrite morphogenesis Source: Ensembl
  7. positive regulation of filopodium assembly Source: Ensembl
  8. positive regulation of lamellipodium assembly Source: Ensembl
  9. positive regulation of neuron differentiation Source: Ensembl
  10. regulation of myosin II filament organization Source: Ensembl
  11. response to antibiotic Source: Ensembl
  12. response to carbohydrate Source: Ensembl
  13. spindle localization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Actin-related protein 3Imported
Submitted name:
cDNA FLJ51148, highly similar to Actin-like protein 3Imported
Submitted name:
cDNA FLJ52434, highly similar to Actin-like protein 3Imported
Submitted name:
cDNA, FLJ79112, highly similar to Actin-like protein 3Imported
Submitted name:
cDNA, FLJ79295, highly similar to Actin-like protein 3Imported
Gene namesi
Name:ACTR3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:170. ACTR3.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. excitatory synapse Source: Ensembl
  3. Golgi membrane Source: Ensembl
  4. hemidesmosome Source: Ensembl
  5. lamellipodium Source: Ensembl
  6. podosome Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiB4DXW1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB4DXW1.
SMRiB4DXW1. Positions 1-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074695.
HOVERGENiHBG003771.

Family and domain databases

InterProiIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR015623. Arp3.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF175. PTHR11937:SF175. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DXW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGVDDLDFF IGDEAIEKPT YATKWPIRHG IVEDWDLMER FMEQVIFKYL
60 70 80 90 100
RAEPEDHYFL LTEPPLNTPE NREYTAEIMF ESFNVPGLYI AVQAVLALAA
110 120 130 140 150
SWTSRQVGER TLTGTVIDSG DGVTHVIPVA EGYVIGSCIK HIPIAGRDIT
160 170 180 190 200
YFIQQLLRDR EVGIPPEQSL ETAKAVKERY SYVCPDLVKE FNKYDTDGSK
210 220 230 240 250
WIKQYTGINA ISKKEFSIDV GYERFLGPEI FFHPEFANPD FTQPISEVVD
260 270 280 290 300
EVIQNCPIDV RRPLYKNIVL SGGSTMFRDF GRRLQRDLKR TVDARLKLSE
310 320 330 340 350
ELSGGRLKPK PIDVQVITHH MQRYAVWFGG SMLASTPEFY QVCHTKKDYE
360
EIGPSICRHN PVFGVMS
Length:367
Mass (Da):42,004
Last modified:September 23, 2008 - v1
Checksum:iD757C18AD8C4174B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC110769 Genomic DNA. No translation available.
AK302152 mRNA. Translation: BAG63523.1.
AK302359 mRNA. Translation: BAG63684.1.
AK316213 mRNA. Translation: BAH14584.1.
AK316396 mRNA. Translation: BAH14767.1.
RefSeqiNP_001264069.1. NM_001277140.1.
UniGeneiHs.433512.
Hs.595349.

Genome annotation databases

EnsembliENST00000535589; ENSP00000444987; ENSG00000115091.
GeneIDi10096.
KEGGihsa:10096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC110769 Genomic DNA. No translation available.
AK302152 mRNA. Translation: BAG63523.1 .
AK302359 mRNA. Translation: BAG63684.1 .
AK316213 mRNA. Translation: BAH14584.1 .
AK316396 mRNA. Translation: BAH14767.1 .
RefSeqi NP_001264069.1. NM_001277140.1.
UniGenei Hs.433512.
Hs.595349.

3D structure databases

ProteinModelPortali B4DXW1.
SMRi B4DXW1. Positions 1-366.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000535589 ; ENSP00000444987 ; ENSG00000115091 .
GeneIDi 10096.
KEGGi hsa:10096.

Organism-specific databases

CTDi 10096.
HGNCi HGNC:170. ACTR3.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00550000074695.
HOVERGENi HBG003771.

Miscellaneous databases

ChiTaRSi ACTR3. human.
GenomeRNAii 10096.
NextBioi 35476075.

Gene expression databases

ExpressionAtlasi B4DXW1. baseline and differential.

Family and domain databases

InterProi IPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR015623. Arp3.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
PTHR11937:SF175. PTHR11937:SF175. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
PROSITEi PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB4DXW1_HUMAN
AccessioniPrimary (citable) accession number: B4DXW1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3