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Protein

Zinc finger protein 732

Gene

ZNF732

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri141 – 163C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 189C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 244C2H2-type 4PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri250 – 272C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 16; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31401-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 732
Gene namesi
Name:ZNF732
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:37138. ZNF732.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186777.
PharmGKBiPA162410265.

Polymorphism and mutation databases

BioMutaiZNF732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003829221 – 585Zinc finger protein 732Add BLAST585

Proteomic databases

EPDiB4DXR9.
MaxQBiB4DXR9.
PaxDbiB4DXR9.
PRIDEiB4DXR9.

PTM databases

iPTMnetiB4DXR9.
PhosphoSitePlusiB4DXR9.

Expressioni

Gene expression databases

ExpressionAtlasiB4DXR9. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi576318. 1 interactor.
STRINGi9606.ENSP00000415774.

Structurei

3D structure databases

ProteinModelPortaliB4DXR9.
SMRiB4DXR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri141 – 163C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 189C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 244C2H2-type 4PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri250 – 272C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 16; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiB4DXR9.
OMAiDKTPKCK.
OrthoDBiEOG091G02KC.
PhylomeDBiB4DXR9.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DXR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL ISLGVAISNP
60 70 80 90 100
DLVIYLEQRK EPYKVKIHET VAKHPAVCSH FTQDFLPVQG IEDSFHKLIL
110 120 130 140 150
RRYEKCGHEN LELRKSCKRK VQKGGYNEFN QCLSTIQSKI FQCNVHVKVF
160 170 180 190 200
STFSNSNQRR IRHTGEKHFK ECGKSFQKFS DLTQHQGIHA GEKPYTCEEC
210 220 230 240 250
GKDFKWYLIF NEYEIIHTGE KPFTCEECGN IFTTSSNFAK HKVHTGEKSY
260 270 280 290 300
KYEECGKAFN RSSTLTKHKR IHAEEKPFTC EECGKIITSS SNVAKHKKIH
310 320 330 340 350
TGEKLYKCQE CGKVFNRSTT LTKHNRIHTG EKPYTCEECG KAFSRSSVLN
360 370 380 390 400
EHKRIHTGEK PYKCEQCGKA FRQSATLNKH KSIHTGEKPY TCEECGKAFS
410 420 430 440 450
RFTTLNEHKR IHTGERPHKC EECGKAFGWS TDLNKHKIIH TGEKPYKCEE
460 470 480 490 500
CGKAFGWSAY LSKHKKIHTG EKPYRCEECG KAFLCSRALN KHKTIHTGEK
510 520 530 540 550
PYECEECGKA FGWSTYLSKH KKIHTGEKPY RCEECGKAFR RSRVLNKYKT
560 570 580
IHTGDKTPKC KGCGKAFKWS SYLNQHNKIY TGEKL
Length:585
Mass (Da):67,839
Last modified:September 23, 2008 - v1
Checksum:iA0D1D707D7245864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302099 mRNA. Translation: BAG63481.1.
AC079140 Genomic DNA. No translation available.
CCDSiCCDS46990.1.
RefSeqiNP_001131080.1. NM_001137608.1.
UniGeneiHs.698668.

Genome annotation databases

EnsembliENST00000419098; ENSP00000415774; ENSG00000186777.
GeneIDi654254.
KEGGihsa:654254.
UCSCiuc062udf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302099 mRNA. Translation: BAG63481.1.
AC079140 Genomic DNA. No translation available.
CCDSiCCDS46990.1.
RefSeqiNP_001131080.1. NM_001137608.1.
UniGeneiHs.698668.

3D structure databases

ProteinModelPortaliB4DXR9.
SMRiB4DXR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576318. 1 interactor.
STRINGi9606.ENSP00000415774.

PTM databases

iPTMnetiB4DXR9.
PhosphoSitePlusiB4DXR9.

Polymorphism and mutation databases

BioMutaiZNF732.

Proteomic databases

EPDiB4DXR9.
MaxQBiB4DXR9.
PaxDbiB4DXR9.
PRIDEiB4DXR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419098; ENSP00000415774; ENSG00000186777.
GeneIDi654254.
KEGGihsa:654254.
UCSCiuc062udf.1. human.

Organism-specific databases

CTDi654254.
GeneCardsiZNF732.
HGNCiHGNC:37138. ZNF732.
neXtProtiNX_B4DXR9.
OpenTargetsiENSG00000186777.
PharmGKBiPA162410265.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiB4DXR9.
OMAiDKTPKCK.
OrthoDBiEOG091G02KC.
PhylomeDBiB4DXR9.
TreeFamiTF342117.

Enzyme and pathway databases

BioCyciZFISH:G66-31401-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii654254.
PROiB4DXR9.

Gene expression databases

ExpressionAtlasiB4DXR9. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN732_HUMAN
AccessioniPrimary (citable) accession number: B4DXR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.