ID B4DXL9_HUMAN Unreviewed; 379 AA. AC B4DXL9; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 23-SEP-2008, sequence version 1. DT 27-MAR-2024, entry version 79. DE SubName: Full=cDNA FLJ53677, highly similar to Drebrin-like protein {ECO:0000313|EMBL:BAG63431.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG63431.1}; RN [1] {ECO:0000313|EMBL:BAG63431.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis {ECO:0000313|EMBL:BAG63431.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project focused on splicing variants."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection, CC dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, CC lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cell projection, neuron CC projection {ECO:0000256|ARBA:ARBA00004487}. Cell projection, podosome CC {ECO:0000256|ARBA:ARBA00004188}. Cell projection, ruffle CC {ECO:0000256|ARBA:ARBA00004466}. Cytoplasm, cell cortex CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic vesicle, clathrin-coated CC vesicle membrane {ECO:0000256|ARBA:ARBA00004145}; Peripheral membrane CC protein {ECO:0000256|ARBA:ARBA00004145}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004145}. Early endosome CC {ECO:0000256|ARBA:ARBA00004412}. Endosome CC {ECO:0000256|ARBA:ARBA00004177}. Golgi apparatus membrane CC {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004255}. Perikaryon CC {ECO:0000256|ARBA:ARBA00004484}. Postsynaptic density CC {ECO:0000256|ARBA:ARBA00034105}. Synapse CC {ECO:0000256|ARBA:ARBA00034103}. CC -!- SIMILARITY: Belongs to the ABP1 family. CC {ECO:0000256|ARBA:ARBA00011039}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK302037; BAG63431.1; -; mRNA. DR AlphaFoldDB; B4DXL9; -. DR PeptideAtlas; B4DXL9; -. DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell. DR GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell. DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell. DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0002102; C:podosome; IEA:UniProtKB-SubCell. DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell. DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW. DR CDD; cd11281; ADF_drebrin_like; 1. DR CDD; cd11960; SH3_Abp1_eu; 1. DR Gene3D; 3.40.20.10; Severin; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR InterPro; IPR002108; ADF-H. DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf. DR InterPro; IPR035717; Drebrin-like_SH3. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR10829; CORTACTIN AND DREBRIN; 1. DR PANTHER; PTHR10829:SF12; DREBRIN-LIKE PROTEIN; 1. DR Pfam; PF00241; Cofilin_ADF; 1. DR Pfam; PF14604; SH3_9; 1. DR SMART; SM00102; ADF; 1. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF55753; Actin depolymerizing proteins; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS51263; ADF_H; 1. DR PROSITE; PS50002; SH3; 1. PE 2: Evidence at transcript level; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Membrane {ECO:0000256|ARBA:ARBA00022475}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}. FT DOMAIN 1..81 FT /note="ADF-H" FT /evidence="ECO:0000259|PROSITE:PS51263" FT DOMAIN 320..379 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT REGION 156..232 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 246..271 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 156..174 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 175..197 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 198..214 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 215..232 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 379 AA; 42726 MW; 8D18D4986F114C7D CRC64; MVEELNSGKV MYAFCRVKDP NSGLPKFVLI NWTGEGVNDV RKGACASHVS TMASFLKGAH VTINARAEED VEPECIMEKV AKASGANYSF HKESGRFQDV GPQAPVGSVY QKTNAVSEIK RVGKDSFWAK AEKEEENRRL EEKRRAEEAQ RQLEQERRER ELREAARREQ RYQEQGGEAS PQSRTWEQQQ EVVSRNRNEQ ESAVHPREIF KQKERAMSTT SISSPQPGKL RSPFLQKQLT QPETHFGREP AAAISRPRAD LPAEEPAPST PPCLVQAEEE AVYEEPPEQE TFYEQPPLVQ QQGAGSEHID HHIQGQGLSG QGLCARALYD YQAADDTEIS FDPENLITGI EVIDEGWWRG YGPDGHFGMF PANYVELIE //