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Protein

Zinc finger protein 736

Gene

ZNF736

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 736
Gene namesi
Name:ZNF736
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:32467. ZNF736.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiZNF736.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Zinc finger protein 736PRO_0000395343Add
BLAST

Proteomic databases

PaxDbiB4DX44.
PRIDEiB4DX44.

PTM databases

iPTMnetiB4DX44.
PhosphoSiteiB4DX44.

Expressioni

Gene expression databases

BgeeiENSG00000234444.
GenevisibleiB4DX44. HS.

Organism-specific databases

HPAiHPA061215.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347210.

Structurei

3D structure databases

ProteinModelPortaliB4DX44.
SMRiB4DX44. Positions 4-44, 143-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiB4DX44.
KOiK09228.
OMAiERCYKCE.
OrthoDBiEOG091G02KC.
PhylomeDBiB4DX44.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DX44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL VSLGLAIFKP
60 70 80 90 100
DLMTCLEQRK EPWKVKRQEA VAKHPAGSFH FTAEILPDHD IKDSFQKVIL
110 120 130 140 150
RKYGSCDLNN LHLKKDYQSV GNCKGQKSSY NGLHQCLSAT HSKTCQCNKC
160 170 180 190 200
GRGFQLCSIF TEHKDIFSRE KCHKCEECGK DCRLFSDFTR HKKIHTVERC
210 220 230 240 250
YKCEECGKAF KKFSNLTEHK RVHTGEKPYK CEGCGKTFTC SSTLVKHKRN
260 270 280 290 300
HTGDRPYKCE ECGKAFKCFS DLTNHKRIHT GEKPYKCEEC NKAYRWFSDL
310 320 330 340 350
AKHKIIHTGD KPYTCNECGK AFKWFSALSK HKRIHTGEKP YICEECGKAF
360 370 380 390 400
TRSSTLFNHK RIHMEERPYK CEECSKTFKC FSDLTNHKRI HTGEKPYKCE
410 420
ECGKASSWFS HLIRHKRIHT REKLHKC
Length:427
Mass (Da):49,868
Last modified:June 28, 2011 - v2
Checksum:i6C26A8CCF635DD88
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti268 – 2681C → R in BAG63256 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301806 mRNA. Translation: BAG63256.1.
AC073270 Genomic DNA. No translation available.
CCDSiCCDS55114.1.
RefSeqiNP_001164376.1. NM_001170905.2.
UniGeneiHs.386162.
Hs.734771.

Genome annotation databases

EnsembliENST00000355095; ENSP00000347210; ENSG00000234444.
ENST00000423484; ENSP00000400852; ENSG00000234444.
GeneIDi728927.
KEGGihsa:728927.
UCSCiuc003tsz.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301806 mRNA. Translation: BAG63256.1.
AC073270 Genomic DNA. No translation available.
CCDSiCCDS55114.1.
RefSeqiNP_001164376.1. NM_001170905.2.
UniGeneiHs.386162.
Hs.734771.

3D structure databases

ProteinModelPortaliB4DX44.
SMRiB4DX44. Positions 4-44, 143-427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347210.

PTM databases

iPTMnetiB4DX44.
PhosphoSiteiB4DX44.

Polymorphism and mutation databases

BioMutaiZNF736.

Proteomic databases

PaxDbiB4DX44.
PRIDEiB4DX44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355095; ENSP00000347210; ENSG00000234444.
ENST00000423484; ENSP00000400852; ENSG00000234444.
GeneIDi728927.
KEGGihsa:728927.
UCSCiuc003tsz.5. human.

Organism-specific databases

CTDi728927.
GeneCardsiZNF736.
HGNCiHGNC:32467. ZNF736.
HPAiHPA061215.
neXtProtiNX_B4DX44.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiB4DX44.
KOiK09228.
OMAiERCYKCE.
OrthoDBiEOG091G02KC.
PhylomeDBiB4DX44.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF736. human.
GenomeRNAii728927.
PROiB4DX44.

Gene expression databases

BgeeiENSG00000234444.
GenevisibleiB4DX44. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN736_HUMAN
AccessioniPrimary (citable) accession number: B4DX44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: June 28, 2011
Last modified: September 7, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.