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Protein

Zinc finger protein 736

Gene

ZNF736

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 736
Gene namesi
Name:ZNF736
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000234444.9.
HGNCiHGNC:32467. ZNF736.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000234444.

Polymorphism and mutation databases

BioMutaiZNF736.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003953431 – 427Zinc finger protein 736Add BLAST427

Proteomic databases

EPDiB4DX44.
PaxDbiB4DX44.
PRIDEiB4DX44.

PTM databases

iPTMnetiB4DX44.
PhosphoSitePlusiB4DX44.

Expressioni

Gene expression databases

BgeeiENSG00000234444.
ExpressionAtlasiB4DX44. baseline and differential.
GenevisibleiB4DX44. HS.

Organism-specific databases

HPAiHPA051027.
HPA061215.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347210.

Structurei

3D structure databases

ProteinModelPortaliB4DX44.
SMRiB4DX44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139354.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiB4DX44.
KOiK09228.
OMAiERCYKCE.
OrthoDBiEOG091G02KC.
PhylomeDBiB4DX44.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.

Sequencei

Sequence statusi: Complete.

B4DX44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL VSLGLAIFKP
60 70 80 90 100
DLMTCLEQRK EPWKVKRQEA VAKHPAGSFH FTAEILPDHD IKDSFQKVIL
110 120 130 140 150
RKYGSCDLNN LHLKKDYQSV GNCKGQKSSY NGLHQCLSAT HSKTCQCNKC
160 170 180 190 200
GRGFQLCSIF TEHKDIFSRE KCHKCEECGK DCRLFSDFTR HKKIHTVERC
210 220 230 240 250
YKCEECGKAF KKFSNLTEHK RVHTGEKPYK CEGCGKTFTC SSTLVKHKRN
260 270 280 290 300
HTGDRPYKCE ECGKAFKCFS DLTNHKRIHT GEKPYKCEEC NKAYRWFSDL
310 320 330 340 350
AKHKIIHTGD KPYTCNECGK AFKWFSALSK HKRIHTGEKP YICEECGKAF
360 370 380 390 400
TRSSTLFNHK RIHMEERPYK CEECSKTFKC FSDLTNHKRI HTGEKPYKCE
410 420
ECGKASSWFS HLIRHKRIHT REKLHKC
Length:427
Mass (Da):49,868
Last modified:June 28, 2011 - v2
Checksum:i6C26A8CCF635DD88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268C → R in BAG63256 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301806 mRNA. Translation: BAG63256.1.
AC073270 Genomic DNA. No translation available.
CCDSiCCDS55114.1.
RefSeqiNP_001164376.1. NM_001170905.2.
UniGeneiHs.386162.
Hs.734771.

Genome annotation databases

EnsembliENST00000355095; ENSP00000347210; ENSG00000234444.
ENST00000423484; ENSP00000400852; ENSG00000234444.
GeneIDi728927.
KEGGihsa:728927.
UCSCiuc003tsz.5. human.

Similar proteinsi

Entry informationi

Entry nameiZN736_HUMAN
AccessioniPrimary (citable) accession number: B4DX44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families