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B4DWY7

- B4DWY7_HUMAN

UniProt

B4DWY7 - B4DWY7_HUMAN

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Protein
Submitted name:

Uncharacterized protein

Gene
ADAM2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

IntegrinImported

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Submitted name:
cDNA FLJ60930, highly similar to ADAM 2 (A disintegrin and metalloproteinase domain 2)Imported
Gene namesi
Name:ADAM2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:198. ADAM2.

Subcellular locationi

Secreted By similarity SAAS annotations

Keywords - Cellular componenti

SecretedSAAS annotations

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliB4DWY7.
SMRiB4DWY7. Positions 172-576.

Family & Domainsi

Sequence similaritiesi

Contains 1 disintegrin domain.UniRule annotation
Contains 1 peptidase M12B domain.UniRule annotation
Contains disintegrin domain.SAAS annotations
Contains peptidase M12B domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000230883.
HOVERGENiHBG103628.
KOiK06833.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4DWY7-1 [UniParc]FASTAAdd to Basket

« Hide

MWRVLFLLSG LGGLRMDSNF DSLPVQITVP EKIRSIIKEG IESQASYKIV    50
IEGKPYTVNL MQKNFLPHNF RVYSYSGTGI MKPLDQDFQN FCHYQGYIEG 100
YPKSVVMVST CTGLRGVLQF ENVSYGIEPL ESSVGFEHVI YQVKHKKADV 150
SLYNEKDIES RDLSFKLQSV EPQQDFAKYI EMHVIVEKQL YNHMGSDTTV 200
VAQKVFQLIG LTNAIFVSFN ITIILSSLEL WIDENKIATT GEANELLHTF 250
LRWKTSYLVL RPHDVAFLLV YREKSNYVGA TFQGKMCDAN YAGGVVLHPR 300
TISLESLAVI LAQLLSLSMG ITYDDINKCQ CSGAVCIMNP EAIHFSGVKI 350
FSNCSFEDFA HFISKQKSQC LHNQPRLDPF FKQQAVCGNA KLEAGEECDC 400
GTEQDCALIG ETCCDIATCR FKAGSNCAEG PCCENCLFMS KERMCRPSFE 450
ECDLPEYCNG SSASCPENHY VQTGHPCGLN QWICIDGVCM SGDKQCTDTF 500
GKEVEFGPSE CYSHLNSKTD VSGNCGISDS GYTQCEVCRN QRCVSSSYLG 550
YDCTTDKCND RGVCNNKKHC HCSASYLPPD CSVQSDLWPG GSIDSGNFPP 600
VAIPARLPER RYIENIYHSK PMRWPFFLFI PFFIIFCVLI AIMVKVNFQR 650
KKWRTEDYSS DEQPESESEP KG 672
Length:672
Mass (Da):75,588
Last modified:September 23, 2008 - v1
Checksum:i251DEC8937B5504E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC136365 Genomic DNA. No translation available.
AP005902 Genomic DNA. No translation available.
AK301734 mRNA. Translation: BAG63199.1.
RefSeqiNP_001265043.1. NM_001278114.1.
UniGeneiHs.177959.

Genome annotation databases

EnsembliENST00000521880; ENSP00000429352; ENSG00000104755.
GeneIDi2515.
KEGGihsa:2515.
UCSCiuc011lck.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC136365 Genomic DNA. No translation available.
AP005902 Genomic DNA. No translation available.
AK301734 mRNA. Translation: BAG63199.1 .
RefSeqi NP_001265043.1. NM_001278114.1.
UniGenei Hs.177959.

3D structure databases

ProteinModelPortali B4DWY7.
SMRi B4DWY7. Positions 172-576.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000521880 ; ENSP00000429352 ; ENSG00000104755 .
GeneIDi 2515.
KEGGi hsa:2515.
UCSCi uc011lck.3. human.

Organism-specific databases

CTDi 2515.
HGNCi HGNC:198. ADAM2.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000230883.
HOVERGENi HBG103628.
KOi K06833.

Miscellaneous databases

GenomeRNAii 2515.
NextBioi 35475848.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.
  3. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB4DWY7_HUMAN
AccessioniPrimary (citable) accession number: B4DWY7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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